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CsiR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-2-hydroxyglutarate ketoglutarate GABA GABA_Ext CsiD CsiR GabD GabP GabT L-glutamate LhgO csiD-lhgO-gabDTP csiD-lhgO-gabDTP_mRNA perhydrol oxygen succinate succ-S-ald


Gensor Unit       
Name: CsiR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0042450 - arginine biosynthetic process via ornithine
GO:0006974 - cellular response to DNA damage stimulus
GO:0009450 - gamma-aminobutyric acid catabolic process
GO:0006807 - nitrogen compound metabolic process
GO:0051289 - protein homotetramerization
GO:0090549 - response to carbon starvation
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
molecular_function GO:0003973 - (S)-2-hydroxy-acid oxidase activity
GO:0047545 - 2-hydroxyglutarate dehydrogenase activity
GO:0003867 - 4-aminobutyrate transaminase activity
GO:0034419 - L-2-hydroxyglutarate oxidase activity
GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (19 more...)
Function Name Type
simple_molecule 2-acetamido-5-oxopentanoate simple_molecule
simple_molecule 2-hydroxyglutarate simple_molecule
protein CsiD protein
protein CsiR protein
simple_molecule GABA simple_molecule
simple_molecule GABA_Ext simple_molecule
protein GabD protein
protein GabP protein
protein GabT protein
simple_molecule L-glutamate simple_molecule
protein LhgO protein
simple_molecule acetylornithine simple_molecule
gene csiD-lhgO-gabDTP gene
RNA csiD-lhgO-gabDTP_mRNA RNA
simple_molecule ketoglutarate simple_molecule
simple_molecule oxygen simple_molecule
simple_molecule perhydrol simple_molecule
simple_molecule succ-S-ald simple_molecule
simple_molecule succinate simple_molecule


Reactions       
Showing 11 reactions
CsiR csiD-lhgO-gabDTP csiD-lhgO-gabDTP_mRNA
Name: csiD-lhgO-gabDTP -> csiD-lhgO-gabDTP_mRNA
Description: Transcription of transcription unit csiD-lhgO-gabDTP. Reaction inhibition by CsiR.
Type: transcription
Pathway Components: csiD-lhgO-gabDTP - CsiR -> csiD-lhgO-gabDTP_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor CsiR protein nd nd
reactant csiD-lhgO-gabDTP gene nd nd
product csiD-lhgO-gabDTP_mRNA RNA nd nd
csiD-lhgO-gabDTP_mRNA CsiD
Name: csiD-lhgO-gabDTP_mRNA -> CsiD
Description: Translation of CsiD
Type: translation
Pathway Components: csiD-lhgO-gabDTP_mRNA -> CsiD
Components:
Function Name Type Evidence Reference(s)
product CsiD protein nd nd
reactant csiD-lhgO-gabDTP_mRNA RNA nd nd
csiD-lhgO-gabDTP_mRNA LhgO
Name: csiD-lhgO-gabDTP_mRNA -> LhgO
Description: Translation of LhgO
Type: translation
Pathway Components: csiD-lhgO-gabDTP_mRNA -> LhgO
Components:
Function Name Type Evidence Reference(s)
product LhgO protein nd nd
reactant csiD-lhgO-gabDTP_mRNA RNA nd nd
LhgO 2-hydroxyglutarate + oxygen ketoglutarate + perhydrol
Name: 2-hydroxyglutarate + oxygen -> ketoglutarate + perhydrol
Description: Reaction transforming 2-hydroxyglutarate, oxygen into ketoglutarate, perhydrol
Type: state transition
Pathway Components: 2-hydroxyglutarate + oxygen - LhgO -> ketoglutarate + perhydrol
Components:
Function Name Type Evidence Reference(s)
reactant 2-hydroxyglutarate simple_molecule nd nd
catalyzer LhgO protein nd nd
product ketoglutarate simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product perhydrol simple_molecule nd nd
csiD-lhgO-gabDTP_mRNA GabD
Name: csiD-lhgO-gabDTP_mRNA -> GabD
Description: Translation of GabD
Type: translation
Pathway Components: csiD-lhgO-gabDTP_mRNA -> GabD
Components:
Function Name Type Evidence Reference(s)
product GabD protein nd nd
reactant csiD-lhgO-gabDTP_mRNA RNA nd nd
GabD succ-S-ald succinate
Name: succ-S-ald -> succinate
Description: Reaction transforming succ-S-ald into succinate
Type: state transition
Pathway Components: succ-S-ald - GabD -> succinate
Components:
Function Name Type Evidence Reference(s)
catalyzer GabD protein nd nd
reactant succ-S-ald simple_molecule nd nd
product succinate simple_molecule nd nd
csiD-lhgO-gabDTP_mRNA GabT
Name: csiD-lhgO-gabDTP_mRNA -> GabT
Description: Translation of GabT
Type: translation
Pathway Components: csiD-lhgO-gabDTP_mRNA -> GabT
Components:
Function Name Type Evidence Reference(s)
product GabT protein nd nd
reactant csiD-lhgO-gabDTP_mRNA RNA nd nd
GabT ketoglutarate + GABA L-glutamate + succ-S-ald
Name: ketoglutarate + GABA -> L-glutamate + succ-S-ald
Description: Reaction transforming ketoglutarate, GABA into L-glutamate, succ-S-ald
Type: state transition
Pathway Components: ketoglutarate + GABA - GabT -> L-glutamate + succ-S-ald
Components:
Function Name Type Evidence Reference(s)
reactant GABA simple_molecule nd nd
catalyzer GabT protein nd nd
product L-glutamate simple_molecule nd nd
reactant ketoglutarate simple_molecule nd nd
product succ-S-ald simple_molecule nd nd
GabT 2-acetamido-5-oxopentanoate + L-glutamate acetylornithine + ketoglutarate
Name: 2-acetamido-5-oxopentanoate + L-glutamate -> acetylornithine + ketoglutarate
Description: Reaction transforming 2-acetamido-5-oxopentanoate, L-glutamate into acetylornithine, ketoglutarate
Type: state transition
Pathway Components: 2-acetamido-5-oxopentanoate + L-glutamate - GabT -> acetylornithine + ketoglutarate
Components:
Function Name Type Evidence Reference(s)
reactant 2-acetamido-5-oxopentanoate simple_molecule nd nd
catalyzer GabT protein nd nd
reactant L-glutamate simple_molecule nd nd
product acetylornithine simple_molecule nd nd
product ketoglutarate simple_molecule nd nd
csiD-lhgO-gabDTP_mRNA GabP
Name: csiD-lhgO-gabDTP_mRNA -> GabP
Description: Translation of GabP
Type: translation
Pathway Components: csiD-lhgO-gabDTP_mRNA -> GabP
Components:
Function Name Type Evidence Reference(s)
product GabP protein nd nd
reactant csiD-lhgO-gabDTP_mRNA RNA nd nd
GabP GABA_Ext GABA
Name: GABA_Ext -> GABA
Description: Transport of GABA_Ext through a bacterial membrane, leading to the presence of GABA inside the cell.
Type: transport
Pathway Components: GABA_Ext - GabP -> GABA
Components:
Function Name Type Evidence Reference(s)
product GABA simple_molecule nd nd
reactant GABA_Ext simple_molecule nd nd
catalyzer GabP protein nd nd



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