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ChbR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
acetate diacetylchitobiose 6-phosphate N-monoacetylchitobiose 6'-phosphate chbBCARFG ChbR ChbR ChbA beta-D-cellobiose-6'-p chitobiose_Ext chbBCARFG_mRNA N-monoacetylchitobiose PtsH ChbA ChbB chitosamine ChbC chitobiose glucopyranose ChbG glucose-6-P N-monoacetylchitobiose 6'-phosphate HPr - phosphorylated_Ext ChbF ChbB ChbC beta-D-cellobiose_Ext N-acetyl-alpha-D-glucosamine 6-phosphate


Gensor Unit       
Name: ChbR
Description: Molecular biology level
Detailed: In the presence and absence of monoacetylchitobiose-6-phosphate, ChbR dually regulates its own expression and the expression of genes required for diacetylchitobiose import, diacetylchitobiose catabolic process, cellobiose transport, cellobiose catabolic process. Under these conditions, diacetylchitobiose is transformed to monoacetylchitobiose-6-phosphate and ChbR is modified to ChbR-monoacetylchitobiose-6-phosphate, binds its target sites enabling or preventing the expression of its regulated genes. In the absence of monoacetylchitobiose-6-phosphate, ChbR unbinds its target sites both enabling and preventing the expression of its regulated genes.
Less detailed: In the presence and absence of monoacetylchitobiose-6-phosphate, ChbR dually regulates the expression of genes needed for diacetylchitobiose import and catabolic process and cellobiose transport and catabolic process.

Physiology level
Detailed: The presence of monoacetylchitobiose-6-phosphate induces and inhibits the expression of genes involved with diacetylchitobiose import and catabolic process and cellobiose transport and catabolic process. Under these conditions, the genes necessary for diacetylchitobiose transport and conversion to N-acetyl-glucosamine-6-phosphate and chitosamine; and for cellobiose transport and conversion to Glucose-6-phosphate, are dually expressed.
Less detailed:
Classification:
Groups: General function prediction only
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:1902815 - N,N'-diacetylchitobiose import
GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006032 - chitin catabolic process
GO:0052777 - diacetylchitobiose catabolic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008706 - 6-phospho-beta-glucosidase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0003824 - catalytic activity
GO:0036311 - chitin disaccharide deacetylase activity
GO:0001047 - core promoter binding
GO:0019213 - deacetylase activity
Read more >
Components:
  Function Name Type
  protein ChbA protein
  complex ChbA-ChbC-ChbB complex
  protein ChbB protein
  protein ChbC protein
  protein ChbF protein
  protein ChbG protein
  protein ChbR protein
  complex ChbR-N-monoacetylchitobiose 6'-phosphate complex
  simple_molecule HPr - phosphorylated_Ext simple_molecule
  simple_molecule N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
  simple_molecule N-monoacetylchitobiose simple_molecule
  simple_molecule N-monoacetylchitobiose 6'-phosphate simple_molecule
  simple_molecule PtsH simple_molecule
  simple_molecule acetate simple_molecule
  simple_molecule beta-D-cellobiose-6'-p simple_molecule
  simple_molecule beta-D-cellobiose_Ext simple_molecule
  gene chbBCARFG gene
  RNA chbBCARFG_mRNA RNA
  simple_molecule chitobiose simple_molecule
  simple_molecule chitobiose_Ext simple_molecule
  simple_molecule chitosamine simple_molecule
  simple_molecule diacetylchitobiose 6-phosphate simple_molecule
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucose-6-P simple_molecule


Reactions       
Showing 15 reactions
ChbR ChbR ChbR-N-monoacetylchitobiose 6'-phosphate ChbR-N-monoacetylchitobiose 6'-phosphate chbBCARFG chbBCARFG_mRNA
Name: chbBCARFG -> chbBCARFG_mRNA
Description: Transcription of transcription unit chbBCARFG. Reaction activation by ChbR, and ChbR-N-monoacetylchitobiose 6'-phosphate. Reaction inhibition by ChbR, and ChbR-N-monoacetylchitobiose 6'-phosphate.
Type: transcription
Pathway Components: chbBCARFG - ChbR - ChbR-N-monoacetylchitobiose 6'-phosphate - ChbR - ChbR-N-monoacetylchitobiose 6'-phosphate -> chbBCARFG_mRNA
Components:
Function Name Type
activator ChbR protein
inhibitor ChbR protein
activator ChbR-N-monoacetylchitobiose 6'-phosphate complex
inhibitor ChbR-N-monoacetylchitobiose 6'-phosphate complex
reactant chbBCARFG gene
product chbBCARFG_mRNA RNA
N-monoacetylchitobiose 6'-phosphate + ChbR ChbR-N-monoacetylchitobiose 6'-phosphate
Name: N-monoacetylchitobiose 6'-phosphate + ChbR -> ChbR-N-monoacetylchitobiose 6'-phosphate
Description: Reaction transforming N-monoacetylchitobiose 6'-phosphate, ChbR into ChbR-N-monoacetylchitobiose 6'-phosphate
Type: state transition
Pathway Components: N-monoacetylchitobiose 6'-phosphate + ChbR -> ChbR-N-monoacetylchitobiose 6'-phosphate
Components:
Function Name Type
reactant ChbR protein
product ChbR-N-monoacetylchitobiose 6'-phosphate complex
reactant N-monoacetylchitobiose 6'-phosphate simple_molecule
chbBCARFG_mRNA ChbB
Name: chbBCARFG_mRNA -> ChbB
Description: Translation of ChbB
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbB
Components:
Function Name Type
product ChbB protein
reactant chbBCARFG_mRNA RNA
ChbC + ChbB + ChbA ChbA-ChbC-ChbB
Name: ChbC + ChbB + ChbA -> ChbA-ChbC-ChbB
Description: Reaction transforming ChbC, ChbB, ChbA into ChbA-ChbC-ChbB
Type: state transition
Pathway Components: ChbC + ChbB + ChbA -> ChbA-ChbC-ChbB
Components:
Function Name Type
reactant ChbA protein
product ChbA-ChbC-ChbB complex
reactant ChbB protein
reactant ChbC protein
ChbA-ChbC-ChbB HPr - phosphorylated_Ext + chitobiose_Ext diacetylchitobiose 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + chitobiose_Ext -> diacetylchitobiose 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, chitobiose_Ext through a bacterial membrane, leading to the presence of diacetylchitobiose 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + chitobiose_Ext - ChbA-ChbC-ChbB -> diacetylchitobiose 6-phosphate + PtsH
Components:
Function Name Type
catalyzer ChbA-ChbC-ChbB complex
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
reactant chitobiose_Ext simple_molecule
product diacetylchitobiose 6-phosphate simple_molecule
ChbA-ChbC-ChbB HPr - phosphorylated_Ext + beta-D-cellobiose_Ext beta-D-cellobiose-6'-p + PtsH
Name: HPr - phosphorylated_Ext + beta-D-cellobiose_Ext -> beta-D-cellobiose-6'-p + PtsH
Description: Transport of HPr - phosphorylated_Ext, beta-D-cellobiose_Ext through a bacterial membrane, leading to the presence of beta-D-cellobiose-6'-p, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + beta-D-cellobiose_Ext - ChbA-ChbC-ChbB -> beta-D-cellobiose-6'-p + PtsH
Components:
Function Name Type
catalyzer ChbA-ChbC-ChbB complex
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
product beta-D-cellobiose-6'-p simple_molecule
reactant beta-D-cellobiose_Ext simple_molecule
chbBCARFG_mRNA ChbC
Name: chbBCARFG_mRNA -> ChbC
Description: Translation of ChbC
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbC
Components:
Function Name Type
product ChbC protein
reactant chbBCARFG_mRNA RNA
chbBCARFG_mRNA ChbA
Name: chbBCARFG_mRNA -> ChbA
Description: Translation of ChbA
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbA
Components:
Function Name Type
product ChbA protein
reactant chbBCARFG_mRNA RNA
chbBCARFG_mRNA ChbR
Name: chbBCARFG_mRNA -> ChbR
Description: Translation of ChbR
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbR
Components:
Function Name Type
product ChbR protein
reactant chbBCARFG_mRNA RNA
chbBCARFG_mRNA ChbF
Name: chbBCARFG_mRNA -> ChbF
Description: Translation of ChbF
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbF
Components:
Function Name Type
product ChbF protein
reactant chbBCARFG_mRNA RNA
ChbF N-monoacetylchitobiose 6'-phosphate Products
Name: N-monoacetylchitobiose 6'-phosphate -> N-acetyl-α-D-glucosamine 6-phosphate + chitosamine
Description: Reaction transforming N-monoacetylchitobiose 6'-phosphate into N-acetyl-α-D-glucosamine 6-phosphate, chitosamine
Type: state transition
Pathway Components: N-monoacetylchitobiose 6'-phosphate - ChbF -> N-acetyl-α-D-glucosamine 6-phosphate + chitosamine
Components:
Function Name Type
catalyzer ChbF protein
product N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
reactant N-monoacetylchitobiose 6'-phosphate simple_molecule
product chitosamine simple_molecule
ChbF beta-D-cellobiose-6'-p glucopyranose + glucose-6-P
Name: beta-D-cellobiose-6'-p -> glucopyranose + glucose-6-P
Description: Reaction transforming beta-D-cellobiose-6'-p into glucopyranose, glucose-6-P
Type: state transition
Pathway Components: beta-D-cellobiose-6'-p - ChbF -> glucopyranose + glucose-6-P
Components:
Function Name Type
catalyzer ChbF protein
reactant beta-D-cellobiose-6'-p simple_molecule
product glucopyranose simple_molecule
product glucose-6-P simple_molecule
chbBCARFG_mRNA ChbG
Name: chbBCARFG_mRNA -> ChbG
Description: Translation of ChbG
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbG
Components:
Function Name Type
product ChbG protein
reactant chbBCARFG_mRNA RNA
ChbG diacetylchitobiose 6-phosphate Products
Name: diacetylchitobiose 6-phosphate -> N-monoacetylchitobiose 6'-phosphate + acetate
Description: Reaction transforming diacetylchitobiose 6-phosphate into N-monoacetylchitobiose 6'-phosphate, acetate
Type: state transition
Pathway Components: diacetylchitobiose 6-phosphate - ChbG -> N-monoacetylchitobiose 6'-phosphate + acetate
Components:
Function Name Type
catalyzer ChbG protein
product N-monoacetylchitobiose 6'-phosphate simple_molecule
product acetate simple_molecule
reactant diacetylchitobiose 6-phosphate simple_molecule
ChbG chitobiose N-monoacetylchitobiose + acetate
Name: chitobiose -> N-monoacetylchitobiose + acetate
Description: Reaction transforming chitobiose into N-monoacetylchitobiose, acetate
Type: state transition
Pathway Components: chitobiose - ChbG -> N-monoacetylchitobiose + acetate
Components:
Function Name Type
catalyzer ChbG protein
product N-monoacetylchitobiose simple_molecule
product acetate simple_molecule
reactant chitobiose simple_molecule



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