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ChbR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
ChbA ChbB ChbC ChbF ChbG ChbR chitosamine HPr HPr - phosphorylated_Ext N,N'-diacetylchitobiose N,N'-diacetylchitobiose 6'-phosphate N,N'-diacetylchitobiose_Ext N-acetyl-D-glucosamine 6-phosphate N-monoacetylchitobiose N-monoacetylchitobiose 6'-phosphate acetate beta-D-cellobiose 6'-phosphate beta-D-cellobiose_Ext beta-glucose beta-D-glucose-6-P chbBCARFG chbBCARFG_mRNA ChbR N-monoacetylchitobiose-6-phosphate ChbA ChbC ChbB ChbR


Gensor Unit       
Name: ChbR
Description: Molecular biology level
Detailed: In the presence and absence of monoacetylchitobiose-6-phosphate, ChbR dually regulates its own expression and the expression of genes required for diacetylchitobiose import, diacetylchitobiose catabolic process, cellobiose transport, cellobiose catabolic process. Under these conditions, diacetylchitobiose is transformed to monoacetylchitobiose-6-phosphate and ChbR is modified to ChbR-monoacetylchitobiose-6-phosphate, binds its target sites enabling or preventing the expression of its regulated genes. In the absence of monoacetylchitobiose-6-phosphate, ChbR unbinds its target sites both enabling and preventing the expression of its regulated genes.
Less detailed: In the presence and absence of monoacetylchitobiose-6-phosphate, ChbR dually regulates the expression of genes needed for diacetylchitobiose import and catabolic process and cellobiose transport and catabolic process.

Physiology level
Detailed: The presence of monoacetylchitobiose-6-phosphate induces and inhibits the expression of genes involved with diacetylchitobiose import and catabolic process and cellobiose transport and catabolic process. Under these conditions, the genes necessary for diacetylchitobiose transport and conversion to N-acetyl-glucosamine-6-phosphate and chitosamine; and for cellobiose transport and conversion to Glucose-6-phosphate, are dually expressed.
Less detailed:
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:1902815 - N,N'-diacetylchitobiose import
GO:0034219 - carbohydrate transmembrane transport
GO:0052777 - diacetylchitobiose catabolic process
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
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cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0008706 - 6-phospho-beta-glucosidase activity
GO:0003700 - DNA binding transcription factor activity
GO:0036311 - chitin disaccharide deacetylase activity
GO:0001047 - core promoter binding
GO:0019213 - deacetylase activity
GO:0019172 - glyoxalase III activity
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (24 more...)
Function Name Type
protein ChbA protein
complex ChbA-ChbC-ChbB complex
protein ChbB protein
protein ChbC protein
protein ChbF protein
protein ChbG protein
protein ChbR protein
complex ChbR-N-monoacetylchitobiose 6'-phosphate complex
simple_molecule HPr - phosphorylated_Ext simple_molecule
simple_molecule N-acetyl-α-D-glucosamine 6-phosphate simple_molecule
simple_molecule N-monoacetylchitobiose simple_molecule
simple_molecule N-monoacetylchitobiose 6'-phosphate simple_molecule
simple_molecule PtsH simple_molecule
simple_molecule acetate simple_molecule
simple_molecule beta-D-cellobiose-6'-p simple_molecule
simple_molecule beta-D-cellobiose_Ext simple_molecule
gene chbBCARFG gene
RNA chbBCARFG_mRNA RNA
simple_molecule chitobiose simple_molecule
simple_molecule chitobiose_Ext simple_molecule
simple_molecule chitosamine simple_molecule
simple_molecule diacetylchitobiose 6-phosphate simple_molecule
simple_molecule glucopyranose simple_molecule
simple_molecule glucose-6-P simple_molecule


Reactions       
Showing 15 reactions
N-monoacetylchitobiose 6'-phosphate + ChbR ChbR-N-monoacetylchitobiose 6'-phosphate
Name: N-monoacetylchitobiose 6'-phosphate + ChbR -> ChbR-N-monoacetylchitobiose 6'-phosphate
Description: Reaction transforming N-monoacetylchitobiose 6'-phosphate, ChbR into ChbR-N-monoacetylchitobiose 6'-phosphate
Type: state transition
Pathway Components: N-monoacetylchitobiose 6'-phosphate + ChbR -> ChbR-N-monoacetylchitobiose 6'-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant ChbR protein nd nd
product ChbR-N-monoacetylchitobiose 6'-phosphate complex nd nd
reactant N-monoacetylchitobiose 6'-phosphate simple_molecule nd nd
ChbR-N-monoacetylchitobiose 6'-phosphate ChbR-N-monoacetylchitobiose 6'-phosphate chbBCARFG chbBCARFG_mRNA
Name: chbBCARFG -> chbBCARFG_mRNA
Description: Transcription of transcription unit chbBCARFG. Reaction activation by ChbR-N-monoacetylchitobiose 6'-phosphate. Reaction inhibition by ChbR-N-monoacetylchitobiose 6'-phosphate.
Type: transcription
Pathway Components: chbBCARFG - ChbR-N-monoacetylchitobiose 6'-phosphate - ChbR-N-monoacetylchitobiose 6'-phosphate -> chbBCARFG_mRNA
Components:
Function Name Type Evidence Reference(s)
activator ChbR-N-monoacetylchitobiose 6'-phosphate complex nd nd
inhibitor ChbR-N-monoacetylchitobiose 6'-phosphate complex nd nd
reactant chbBCARFG gene nd nd
product chbBCARFG_mRNA RNA nd nd
chbBCARFG_mRNA ChbB
Name: chbBCARFG_mRNA -> ChbB
Description: Translation of ChbB
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbB
Components:
Function Name Type Evidence Reference(s)
product ChbB protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
ChbB + ChbA + ChbC ChbA-ChbC-ChbB
Name: ChbB + ChbA + ChbC -> ChbA-ChbC-ChbB
Description: Reaction transforming ChbB, ChbA, ChbC into ChbA-ChbC-ChbB
Type: state transition
Pathway Components: ChbB + ChbA + ChbC -> ChbA-ChbC-ChbB
Components:
Function Name Type Evidence Reference(s)
reactant ChbA protein nd nd
product ChbA-ChbC-ChbB complex nd nd
reactant ChbB protein nd nd
reactant ChbC protein nd nd
ChbA-ChbC-ChbB HPr - phosphorylated_Ext + chitobiose_Ext diacetylchitobiose 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + chitobiose_Ext -> diacetylchitobiose 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, chitobiose_Ext through a bacterial membrane, leading to the presence of diacetylchitobiose 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + chitobiose_Ext - ChbA-ChbC-ChbB -> diacetylchitobiose 6-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbA-ChbC-ChbB complex nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
reactant chitobiose_Ext simple_molecule nd nd
product diacetylchitobiose 6-phosphate simple_molecule nd nd
ChbA-ChbC-ChbB HPr - phosphorylated_Ext + beta-D-cellobiose_Ext beta-D-cellobiose-6'-p + PtsH
Name: HPr - phosphorylated_Ext + beta-D-cellobiose_Ext -> beta-D-cellobiose-6'-p + PtsH
Description: Transport of HPr - phosphorylated_Ext, beta-D-cellobiose_Ext through a bacterial membrane, leading to the presence of beta-D-cellobiose-6'-p, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + beta-D-cellobiose_Ext - ChbA-ChbC-ChbB -> beta-D-cellobiose-6'-p + PtsH
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbA-ChbC-ChbB complex nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
product beta-D-cellobiose-6'-p simple_molecule nd nd
reactant beta-D-cellobiose_Ext simple_molecule nd nd
chbBCARFG_mRNA ChbC
Name: chbBCARFG_mRNA -> ChbC
Description: Translation of ChbC
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbC
Components:
Function Name Type Evidence Reference(s)
product ChbC protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
chbBCARFG_mRNA ChbA
Name: chbBCARFG_mRNA -> ChbA
Description: Translation of ChbA
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbA
Components:
Function Name Type Evidence Reference(s)
product ChbA protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
chbBCARFG_mRNA ChbR
Name: chbBCARFG_mRNA -> ChbR
Description: Translation of ChbR
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbR
Components:
Function Name Type Evidence Reference(s)
product ChbR protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
chbBCARFG_mRNA ChbF
Name: chbBCARFG_mRNA -> ChbF
Description: Translation of ChbF
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbF
Components:
Function Name Type Evidence Reference(s)
product ChbF protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
ChbF N-monoacetylchitobiose 6'-phosphate Products
Name: N-monoacetylchitobiose 6'-phosphate -> N-acetyl-α-D-glucosamine 6-phosphate + chitosamine
Description: Reaction transforming N-monoacetylchitobiose 6'-phosphate into N-acetyl-α-D-glucosamine 6-phosphate, chitosamine
Type: state transition
Pathway Components: N-monoacetylchitobiose 6'-phosphate - ChbF -> N-acetyl-α-D-glucosamine 6-phosphate + chitosamine
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbF protein nd nd
product N-acetyl-α-D-glucosamine 6-phosphate simple_molecule nd nd
reactant N-monoacetylchitobiose 6'-phosphate simple_molecule nd nd
product chitosamine simple_molecule nd nd
ChbF beta-D-cellobiose-6'-p glucopyranose + glucose-6-P
Name: beta-D-cellobiose-6'-p -> glucopyranose + glucose-6-P
Description: Reaction transforming beta-D-cellobiose-6'-p into glucopyranose, glucose-6-P
Type: state transition
Pathway Components: beta-D-cellobiose-6'-p - ChbF -> glucopyranose + glucose-6-P
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbF protein nd nd
reactant beta-D-cellobiose-6'-p simple_molecule nd nd
product glucopyranose simple_molecule nd nd
product glucose-6-P simple_molecule nd nd
chbBCARFG_mRNA ChbG
Name: chbBCARFG_mRNA -> ChbG
Description: Translation of ChbG
Type: translation
Pathway Components: chbBCARFG_mRNA -> ChbG
Components:
Function Name Type Evidence Reference(s)
product ChbG protein nd nd
reactant chbBCARFG_mRNA RNA nd nd
ChbG diacetylchitobiose 6-phosphate Products
Name: diacetylchitobiose 6-phosphate -> N-monoacetylchitobiose 6'-phosphate + acetate
Description: Reaction transforming diacetylchitobiose 6-phosphate into N-monoacetylchitobiose 6'-phosphate, acetate
Type: state transition
Pathway Components: diacetylchitobiose 6-phosphate - ChbG -> N-monoacetylchitobiose 6'-phosphate + acetate
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbG protein nd nd
product N-monoacetylchitobiose 6'-phosphate simple_molecule nd nd
product acetate simple_molecule nd nd
reactant diacetylchitobiose 6-phosphate simple_molecule nd nd
ChbG chitobiose N-monoacetylchitobiose + acetate
Name: chitobiose -> N-monoacetylchitobiose + acetate
Description: Reaction transforming chitobiose into N-monoacetylchitobiose, acetate
Type: state transition
Pathway Components: chitobiose - ChbG -> N-monoacetylchitobiose + acetate
Components:
Function Name Type Evidence Reference(s)
catalyzer ChbG protein nd nd
product N-monoacetylchitobiose simple_molecule nd nd
product acetate simple_molecule nd nd
reactant chitobiose simple_molecule nd nd



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