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BolA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AmpC BolA D-ala DacC a N-acetylglucosamine--N-acetylmuramyl-(tetrapeptide) pyrophosphoryl-undecaprenol a beta-lactam a lipid II a substituted beta-amino acid ampC ampC_mRNA dacC dacC_mRNA


Gensor Unit       
Name: BolA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0009252 - peptidoglycan biosynthetic process
GO:0008360 - regulation of cell shape
GO:0042493 - response to drug
cellular_component GO:0005887 - integral component of plasma membrane
molecular_function GO:0008800 - beta-lactamase activity
GO:0004180 - carboxypeptidase activity
GO:0004175 - endopeptidase activity
GO:0008658 - penicillin binding
Components: Show/Hide Components Table (12 more...)
Function Name Type
protein AmpC protein
protein BolA protein
protein DacC protein
simple_molecule ala simple_molecule
gene ampC gene
RNA ampC_mRNA RNA
simple_molecule beta-lactam simple_molecule
gene dacC gene
RNA dacC_mRNA RNA
simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule
simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule
simple_molecule substituted beta-amino acid simple_molecule


Reactions       
Showing 6 reactions
BolA BolA ampC ampC_mRNA
Name: ampC -> ampC_mRNA
Description: Transcription of transcription unit ampC. Reaction activation by BolA. Reaction inhibition by BolA.
Type: transcription
Pathway Components: ampC - BolA - BolA -> ampC_mRNA
Components:
Function Name Type Evidence Reference(s)
activator BolA protein nd nd
inhibitor BolA protein nd nd
reactant ampC gene nd nd
product ampC_mRNA RNA nd nd
BolA BolA dacC dacC_mRNA
Name: dacC -> dacC_mRNA
Description: Transcription of transcription unit dacC. Reaction activation by BolA. Reaction inhibition by BolA.
Type: transcription
Pathway Components: dacC - BolA - BolA -> dacC_mRNA
Components:
Function Name Type Evidence Reference(s)
activator BolA protein nd nd
inhibitor BolA protein nd nd
reactant dacC gene nd nd
product dacC_mRNA RNA nd nd
ampC_mRNA AmpC
Name: ampC_mRNA -> AmpC
Description: Translation of AmpC
Type: translation
Pathway Components: ampC_mRNA -> AmpC
Components:
Function Name Type Evidence Reference(s)
product AmpC protein nd nd
reactant ampC_mRNA RNA nd nd
AmpC beta-lactam substituted beta-amino acid
Name: beta-lactam -> substituted beta-amino acid
Description: Reaction transforming beta-lactam into substituted beta-amino acid
Type: state transition
Pathway Components: beta-lactam - AmpC -> substituted beta-amino acid
Components:
Function Name Type Evidence Reference(s)
catalyzer AmpC protein nd nd
reactant beta-lactam simple_molecule nd nd
product substituted beta-amino acid simple_molecule nd nd
dacC_mRNA DacC
Name: dacC_mRNA -> DacC
Description: Translation of DacC
Type: translation
Pathway Components: dacC_mRNA -> DacC
Components:
Function Name Type Evidence Reference(s)
product DacC protein nd nd
reactant dacC_mRNA RNA nd nd
DacC Reactants Products
Name: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Description: Reaction transforming nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide into nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide, ala
Type: state transition
Pathway Components: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide - DacC -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Components:
Function Name Type Evidence Reference(s)
catalyzer DacC protein nd nd
product ala simple_molecule nd nd
product nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule nd nd
reactant nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule nd nd



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