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BetI Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
BetA BetB BetI BetT betIBA betIBA_mRNA betT betT_mRNA betaine aldehyde choline choline Ext glycine betaine BetI choline


Gensor Unit       
Name: BetI
Description: Molecular biology level
Detailed: In the absence of choline BetI negatively regulates the expression of genes required for transport and conversion of choline to glycine betaine. Under this condition, BetI repress its own expression and the expression of its regulated genes. In the presence of choline, BetI is modified to BetI-choline, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In the absence of choline, BetI negatively regulates the expression of genes needed for the response to osmotic stress.

Physiology level
Detailed: The presence of choline induces the expression of genes involved with response to osmotic stress. Under this condition the genes necessary for choline uptake and its conversion to glycine betaine, an osmoprotectant, are expressed.
Less detailed: The presence of choline induces the expression of genes needful for transport and conversion of choline to glycine betaine, an osmoprotectant.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0015871 - choline transport
GO:0019285 - glycine betaine biosynthetic process from choline
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0051289 - protein homotetramerization
GO:0010165 - response to X-ray
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cellular_component GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA binding transcription factor activity
GO:0004029 - aldehyde dehydrogenase (NAD) activity
GO:0008802 - betaine-aldehyde dehydrogenase activity
GO:0008812 - choline dehydrogenase activity
GO:0015220 - choline transmembrane transporter activity
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (15 more...)
Function Name Type
simple_molecule A(H2) simple_molecule
protein BetA protein
protein BetB protein
protein BetI protein
complex BetI-choline complex
protein BetT protein
simple_molecule acceptors simple_molecule
gene betIBA gene
RNA betIBA_mRNA RNA
gene betT gene
RNA betT_mRNA RNA
simple_molecule betaine simple_molecule
simple_molecule betaine aldehyde simple_molecule
simple_molecule choline simple_molecule
simple_molecule choline_Ext simple_molecule


Reactions       
Showing 10 reactions
BetI betIBA betIBA_mRNA
Name: betIBA -> betIBA_mRNA
Description: Transcription of transcription unit betIBA. Reaction inhibition by BetI.
Type: transcription
Pathway Components: betIBA - BetI -> betIBA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor BetI protein nd nd
reactant betIBA gene nd nd
product betIBA_mRNA RNA nd nd
BetI betT betT_mRNA
Name: betT -> betT_mRNA
Description: Transcription of transcription unit betT. Reaction inhibition by BetI.
Type: transcription
Pathway Components: betT - BetI -> betT_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor BetI protein nd nd
reactant betT gene nd nd
product betT_mRNA RNA nd nd
choline + BetI BetI-choline
Name: choline + BetI -> BetI-choline
Description: Reaction transforming choline, BetI into BetI-choline
Type: state transition
Pathway Components: choline + BetI -> BetI-choline
Components:
Function Name Type Evidence Reference(s)
reactant BetI protein nd nd
product BetI-choline complex nd nd
reactant choline simple_molecule nd nd
betT_mRNA BetT
Name: betT_mRNA -> BetT
Description: Translation of BetT
Type: translation
Pathway Components: betT_mRNA -> BetT
Components:
Function Name Type Evidence Reference(s)
product BetT protein nd nd
reactant betT_mRNA RNA nd nd
BetT choline_Ext choline
Name: choline_Ext -> choline
Description: Transport of choline_Ext through a bacterial membrane, leading to the presence of choline inside the cell.
Type: transport
Pathway Components: choline_Ext - BetT -> choline
Components:
Function Name Type Evidence Reference(s)
catalyzer BetT protein nd nd
product choline simple_molecule nd nd
reactant choline_Ext simple_molecule nd nd
betIBA_mRNA BetI
Name: betIBA_mRNA -> BetI
Description: Translation of BetI
Type: translation
Pathway Components: betIBA_mRNA -> BetI
Components:
Function Name Type Evidence Reference(s)
product BetI protein nd nd
reactant betIBA_mRNA RNA nd nd
betIBA_mRNA BetB
Name: betIBA_mRNA -> BetB
Description: Translation of BetB
Type: translation
Pathway Components: betIBA_mRNA -> BetB
Components:
Function Name Type Evidence Reference(s)
product BetB protein nd nd
reactant betIBA_mRNA RNA nd nd
BetB choline betaine aldehyde betaine
Name: betaine aldehyde -> betaine
Description: Reaction transforming betaine aldehyde into betaine
Type: state transition
Pathway Components: betaine aldehyde - BetB - choline -> betaine
Components:
Function Name Type Evidence Reference(s)
catalyzer BetB protein nd nd
product betaine simple_molecule nd nd
reactant betaine aldehyde simple_molecule nd nd
inhibitor choline simple_molecule nd nd
betIBA_mRNA BetA
Name: betIBA_mRNA -> BetA
Description: Translation of BetA
Type: translation
Pathway Components: betIBA_mRNA -> BetA
Components:
Function Name Type Evidence Reference(s)
product BetA protein nd nd
reactant betIBA_mRNA RNA nd nd
BetA acceptors + choline betaine aldehyde + A(H2)
Name: acceptors + choline -> betaine aldehyde + A(H2)
Description: Reaction transforming acceptors, choline into betaine aldehyde, A(H2)
Type: state transition
Pathway Components: acceptors + choline - BetA -> betaine aldehyde + A(H2)
Components:
Function Name Type Evidence Reference(s)
product A(H2) simple_molecule nd nd
catalyzer BetA protein nd nd
reactant acceptors simple_molecule nd nd
product betaine aldehyde simple_molecule nd nd
reactant choline simple_molecule nd nd



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