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BetI Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
BetA BetB BetI BetT betIBA betIBA_mRNA betT betT_mRNA betaine aldehyde choline choline Ext glycine betaine BetI choline


Gensor Unit       
Name: BetI
Description: BetI negatively regulates the expression of genes involved in the response to osmotic stress in the absence of choline. The presence of choline induces the expression of genes related to transport and conversion of choline to glycine betaine, an osmoprotectant.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0016491 - oxidoreductase activity
GO:0016020 - membrane
GO:0008812 - choline dehydrogenase activity
GO:0006066 - alcohol metabolic process
GO:0003677 - DNA binding
GO:0005886 - plasma membrane
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0006578 - amino-acid betaine biosynthetic process
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Components:
Function Name Type
simple molecule glycine betaine simple molecule


Reactions       
Showing 10 reactions
betIBA betIBA_mRNA
Name: betIBA -> betIBA_mRNA
Description: Transcription of transcription unit betIBA; reaction inhibition by BetI.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant betIBA gene nd nd
product betIBA_mRNA RNA nd nd
betT betT_mRNA
Name: betT -> betT_mRNA
Description: Transcription of transcription unit betT; reaction inhibition by BetI.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant betT gene nd nd
product betT_mRNA RNA nd nd
BetI + Choline BetI-Choline
Name: BetI + Choline -> BetI-Choline
Description: Reaction transforming BetI, Choline into BetI-Choline
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant BetI protein nd nd
reactant Choline simple molecule nd nd
product BetI-Choline complex nd nd
betIBA_mRNA BetB
Name: betIBA_mRNA -> BetB
Description: Translation of BetB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant betIBA_mRNA RNA nd nd
product BetB protein nd nd
betaine aldehyde glycine betaine
Name: betaine aldehyde -> glycine betaine
Description: Reaction transforming betaine aldehyde into glycine betaine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product glycine betaine simple molecule nd nd
reactant betaine aldehyde simple molecule nd nd
betT_mRNA BetT
Name: betT_mRNA -> BetT
Description: Translation of BetT
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant betT_mRNA RNA nd nd
product BetT protein nd nd
choline_Ext choline
Name: choline_Ext -> choline
Description: Transport of choline_Ext through a bacterial membrane, leading to the presence of choline inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product choline simple molecule nd nd
reactant choline_Ext simple molecule nd nd
betIBA_mRNA BetI
Name: betIBA_mRNA -> BetI
Description: Translation of BetI
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant betIBA_mRNA RNA nd nd
product BetI protein nd nd
betIBA_mRNA BetA
Name: betIBA_mRNA -> BetA
Description: Translation of BetA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant betIBA_mRNA RNA nd nd
product BetA protein nd nd
choline + an oxidized electron acceptor betaine aldehyde + a reduced electron acceptor
Name: choline + an oxidized electron acceptor -> betaine aldehyde + a reduced electron acceptor
Description: Reaction transforming choline, an oxidized electron acceptor into betaine aldehyde, a reduced electron acceptor
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant an oxidized electron acceptor simple molecule nd nd
product a reduced electron acceptor simple molecule nd nd
product betaine aldehyde simple molecule nd nd
reactant choline simple molecule nd nd



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