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BirA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
7,8-diaminopelargonate 8-amino-7-oxononanoate BioA BioB BioC BioD BioF BirA L-alanine S-adenosyl-4-methylthio-2-oxobutanoate S-adenosyl-L-homocysteine S-adenosyl-L-methionine holo-[ACP] malonyl-[ACP] malonyl-[ACP] methyl ester pimeloyl-[ACP] biotinyl-5'-adenylate bioA bioA_mRNA bioBFCD bioBFCD_mRNA biotin CoA dethiobiotin pimeloyl-CoA BirA biotinyl-5'-adenylate AccB AccB biotin S-adenosyl-L-methionine S-adenosyl-L-methionine L-methionine 5'-deoxyadenosine


Gensor Unit       
Name: BirA
Description: BirA negatively regulates the expression of genes involved in the biotin biosynthetic process in the presence of biotin-5′-AMP. The presence of biotin-5′-AMP inhibits the expression of genes related to the conversion of malonyl-S-ACP to biotin.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0009058 - biosynthetic process
GO:0009102 - biotin biosynthetic process
GO:0008152 - metabolic process
GO:0032259 - methylation
cellular_component GO:0005737 - cytoplasm
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0008710 - 8-amino-7-oxononanoate synthase activity
GO:0005524 - ATP binding
GO:0004015 - adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO:0004076 - biotin synthase activity
GO:0010340 - carboxyl-O-methyltransferase activity
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Components:
Function Name Type
simple molecule pimeloyl-CoA simple molecule


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