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BirA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: BirA
Description: BirA negatively regulates the expression of genes involved in the biotin biosynthetic process in the presence of biotin-5′-AMP. The presence of biotin-5′-AMP inhibits the expression of genes related to the conversion of malonyl-S-ACP to biotin.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0003824 - catalytic activity
GO:0008710 - 8-amino-7-oxononanoate synthase activity
GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0005737 - cytoplasm
GO:0030170 - pyridoxal phosphate binding
GO:0008483 - transaminase activity
GO:0004141 - dethiobiotin synthase activity
GO:0000287 - magnesium ion binding
GO:0016740 - transferase activity
GO:0010340 - carboxyl-O-methyltransferase activity
GO:0008168 - methyltransferase activity
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Components:
Function Name Type
simple molecule pimeloyl-CoA simple molecule


Reactions       
Showing 14 reactions
BirA + bio-5′-AMP BirA-bio-5′-AMP
Name: BirA + bio-5′-AMP -> BirA-bio-5′-AMP
Description: Reaction transforming BirA, bio-5′-AMP into BirA-bio-5′-AMP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant bio-5′-AMP simple molecule nd nd
product BirA-bio-5′-AMP complex nd nd
reactant BirA protein nd nd
bioA bioA_mRNA
Name: bioA -> bioA_mRNA
Description: Transcription of transcription unit bioA; reaction inhibition by BirA-bio-5′-AMP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant bioA gene nd nd
product bioA_mRNA RNA nd nd
bioBFCD bioBFCD_mRNA
Name: bioBFCD -> bioBFCD_mRNA
Description: Transcription of transcription unit bioBFCD; reaction inhibition by BirA-bio-5′-AMP.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product bioBFCD_mRNA RNA nd nd
reactant bioBFCD gene nd nd
bioBFCD_mRNA BioF
Name: bioBFCD_mRNA -> BioF
Description: Translation of BioF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product BioF protein nd nd
reactant bioBFCD_mRNA RNA nd nd
a pimeloyl-[acp] + L-alanine 7-keto-8-aminopelargonate + CO2 + a holo-[acyl-carrier protein]
Name: a pimeloyl-[acp] + L-alanine -> 7-keto-8-aminopelargonate + CO2 + a holo-[acyl-carrier protein]
Description: Reaction transforming a pimeloyl-[acp], L-alanine into 7-keto-8-aminopelargonate, CO2 , a holo-[acyl-carrier protein]
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product CO2 simple molecule nd nd
product a holo-[acyl-carrier protein] simple molecule nd nd
reactant L-alanine simple molecule nd nd
reactant a pimeloyl-[acp] simple molecule nd nd
product 7-keto-8-aminopelargonate simple molecule nd nd
L-alanine + pimeloyl-CoA CO2 + coenzyme A + 7-keto-8-aminopelargonate
Name: L-alanine + pimeloyl-CoA -> CO2 + coenzyme A + 7-keto-8-aminopelargonate
Description: Reaction transforming L-alanine, pimeloyl-CoA into CO2, coenzyme A , 7-keto-8-aminopelargonate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant pimeloyl-CoA simple molecule nd nd
reactant L-alanine simple molecule nd nd
product coenzyme A simple molecule nd nd
product CO2 simple molecule nd nd
product 7-keto-8-aminopelargonate simple molecule nd nd
bioBFCD_mRNA BioC
Name: bioBFCD_mRNA -> BioC
Description: Translation of BioC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant bioBFCD_mRNA RNA nd nd
product BioC protein nd nd
a malonyl-[acp] + S-adenosyl-L-methionine a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine
Name: a malonyl-[acp] + S-adenosyl-L-methionine -> a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine
Description: Reaction transforming a malonyl-[acp], S-adenosyl-L-methionine into a malonyl-[acp] methyl ester, S-adenosyl-L-homocysteine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant S-adenosyl-L-methionine simple molecule nd nd
reactant a malonyl-[acp] simple molecule nd nd
product a malonyl-[acp] methyl ester simple molecule nd nd
product S-adenosyl-L-homocysteine simple molecule nd nd
bioBFCD_mRNA BioB
Name: bioBFCD_mRNA -> BioB
Description: Translation of BioB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant bioBFCD_mRNA RNA nd nd
product BioB protein nd nd
dethiobiotin + S-adenosyl-L-methionine biotin + L-methionine
Name: dethiobiotin + S-adenosyl-L-methionine -> biotin + L-methionine
Description: Reaction transforming dethiobiotin, S-adenosyl-L-methionine into biotin, L-methionine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant dethiobiotin simple molecule nd nd
product L-methionine simple molecule nd nd
reactant S-adenosyl-L-methionine simple molecule nd nd
product biotin simple molecule nd nd
bioBFCD_mRNA BioD
Name: bioBFCD_mRNA -> BioD
Description: Translation of BioD
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant bioBFCD_mRNA RNA nd nd
product BioD protein nd nd
CO2 + 7,8-diaminopelargonate dethiobiotin
Name: CO2 + 7,8-diaminopelargonate -> dethiobiotin
Description: Reaction transforming CO2, 7,8-diaminopelargonate into dethiobiotin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product dethiobiotin simple molecule nd nd
reactant 7,8-diaminopelargonate simple molecule nd nd
reactant CO2 simple molecule nd nd
bioA_mRNA BioA
Name: bioA_mRNA -> BioA
Description: Translation of BioA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product BioA protein nd nd
reactant bioA_mRNA RNA nd nd
S-adenosyl-L-methionine + 7-keto-8-aminopelargonate S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminopelargonate
Name: S-adenosyl-L-methionine + 7-keto-8-aminopelargonate -> S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminopelargonate
Description: Reaction transforming S-adenosyl-L-methionine, 7-keto-8-aminopelargonate into S-adenosyl-4-methylthio-2-oxobutanoate, 7,8-diaminopelargonate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant S-adenosyl-L-methionine simple molecule nd nd
product 7,8-diaminopelargonate simple molecule nd nd
product S-adenosyl-4-methylthio-2-oxobutanoate simple molecule nd nd
reactant 7-keto-8-aminopelargonate simple molecule nd nd



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