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BaeR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
spy_mRNA novobiocin TolC MdtC drug AcrD TolC mdtABCD-baeSR Spy MdtD TolC spy BaeS BaeR mdtABCD-baeSR_mRNA novobiocin_Ext deoxycholate AcrA deoxycholate_Ext MdtA BaeR AcrD drug_Ext acrD_mRNA MdtB MdtC phosphate MdtB AcrA MdtA phosphate acrD


Gensor Unit       
Name: BaeR
Signal name: Envelope disorder
indole
zinc
flavonoids
sodium tungstate.
Classification:
Groups: Posttranslational modification, protein turnover, chaperones
Carbohydrate transport and metabolism
Signal transduction mechanisms
Defense mechanisms
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:1990507 - ATP-independent chaperone mediated protein folding
GO:0015721 - bile acid and bile salt transport
GO:0061077 - chaperone-mediated protein folding
GO:0046618 - drug export
GO:1990961 - drug transmembrane export
GO:0006855 - drug transmembrane transport
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
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molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0000986 - bacterial-type proximal promoter sequence-specific DNA binding
GO:0015125 - bile acid transmembrane transporter activity
GO:0015238 - drug transmembrane transporter activity
GO:0015307 - drug:proton antiporter activity
GO:0015562 - efflux transmembrane transporter activity
Read more >
Components:
  Function Name Type
  protein AcrA protein
  protein AcrD protein
  complex AcrD-AcrA-TolC complex
  protein BaeR protein
  complex BaeR-phosphate complex
  protein BaeS protein
  protein MdtA protein
  protein MdtB protein
  protein MdtC protein
  protein MdtD protein
  protein Spy protein
  protein TolC protein
  complex TolC-MdtC-MdtB-MdtA complex
  gene acrD gene
  RNA acrD_mRNA RNA
  simple_molecule deoxycholate simple_molecule
  simple_molecule deoxycholate_Ext simple_molecule
  simple_molecule drug simple_molecule
  simple_molecule drug_Ext simple_molecule
  gene mdtABCD-baeSR gene
  RNA mdtABCD-baeSR_mRNA RNA
  simple_molecule novobiocin simple_molecule
  simple_molecule novobiocin_Ext simple_molecule
  simple_molecule phosphate simple_molecule
  gene spy gene
  RNA spy_mRNA RNA


Reactions       
Showing 17 reactions
phosphate + BaeR BaeR-phosphate
Name: phosphate + BaeR -> BaeR-phosphate
Description: Reaction transforming phosphate, BaeR into BaeR-phosphate
Type: state transition
Pathway Components: phosphate + BaeR -> BaeR-phosphate
Components:
Function Name Type
reactant BaeR protein
product BaeR-phosphate complex
reactant phosphate simple_molecule
BaeR-phosphate acrD acrD_mRNA
Name: acrD -> acrD_mRNA
Description: Transcription of transcription unit acrD. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: acrD - BaeR-phosphate -> acrD_mRNA
Components:
Function Name Type
activator BaeR-phosphate complex
reactant acrD gene
product acrD_mRNA RNA
BaeR-phosphate mdtABCD-baeSR mdtABCD-baeSR_mRNA
Name: mdtABCD-baeSR -> mdtABCD-baeSR_mRNA
Description: Transcription of transcription unit mdtABCD-baeSR. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: mdtABCD-baeSR - BaeR-phosphate -> mdtABCD-baeSR_mRNA
Components:
Function Name Type
activator BaeR-phosphate complex
reactant mdtABCD-baeSR gene
product mdtABCD-baeSR_mRNA RNA
BaeR-phosphate spy spy_mRNA
Name: spy -> spy_mRNA
Description: Transcription of transcription unit spy. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: spy - BaeR-phosphate -> spy_mRNA
Components:
Function Name Type
activator BaeR-phosphate complex
reactant spy gene
product spy_mRNA RNA
spy_mRNA Spy
Name: spy_mRNA -> Spy
Description: Translation of Spy
Type: translation
Pathway Components: spy_mRNA -> Spy
Components:
Function Name Type
product Spy protein
reactant spy_mRNA RNA
acrD_mRNA AcrD
Name: acrD_mRNA -> AcrD
Description: Translation of AcrD
Type: translation
Pathway Components: acrD_mRNA -> AcrD
Components:
Function Name Type
product AcrD protein
reactant acrD_mRNA RNA
AcrD + TolC + AcrA AcrD-AcrA-TolC
Name: AcrD + TolC + AcrA -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, TolC, AcrA into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + TolC + AcrA -> AcrD-AcrA-TolC
Components:
Function Name Type
reactant AcrA protein
reactant AcrD protein
product AcrD-AcrA-TolC complex
reactant TolC protein
AcrD-AcrA-TolC TolC-MdtC-MdtB-MdtA drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrD-AcrA-TolC - TolC-MdtC-MdtB-MdtA -> drug
Components:
Function Name Type
catalyzer AcrD-AcrA-TolC complex
catalyzer TolC-MdtC-MdtB-MdtA complex
product drug simple_molecule
reactant drug_Ext simple_molecule
mdtABCD-baeSR_mRNA MdtA
Name: mdtABCD-baeSR_mRNA -> MdtA
Description: Translation of MdtA
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtA
Components:
Function Name Type
product MdtA protein
reactant mdtABCD-baeSR_mRNA RNA
MdtA + TolC + MdtC + MdtB TolC-MdtC-MdtB-MdtA
Name: MdtA + TolC + MdtC + MdtB -> TolC-MdtC-MdtB-MdtA
Description: Reaction transforming MdtA, TolC, MdtC, MdtB into TolC-MdtC-MdtB-MdtA
Type: state transition
Pathway Components: MdtA + TolC + MdtC + MdtB -> TolC-MdtC-MdtB-MdtA
Components:
Function Name Type
reactant MdtA protein
reactant MdtB protein
reactant MdtC protein
reactant TolC protein
product TolC-MdtC-MdtB-MdtA complex
TolC-MdtC-MdtB-MdtA novobiocin_Ext novobiocin
Name: novobiocin_Ext -> novobiocin
Description: Transport of novobiocin_Ext through a bacterial membrane, leading to the presence of novobiocin inside the cell.
Type: transport
Pathway Components: novobiocin_Ext - TolC-MdtC-MdtB-MdtA -> novobiocin
Components:
Function Name Type
catalyzer TolC-MdtC-MdtB-MdtA complex
product novobiocin simple_molecule
reactant novobiocin_Ext simple_molecule
TolC-MdtC-MdtB-MdtA deoxycholate_Ext deoxycholate
Name: deoxycholate_Ext -> deoxycholate
Description: Transport of deoxycholate_Ext through a bacterial membrane, leading to the presence of deoxycholate inside the cell.
Type: transport
Pathway Components: deoxycholate_Ext - TolC-MdtC-MdtB-MdtA -> deoxycholate
Components:
Function Name Type
catalyzer TolC-MdtC-MdtB-MdtA complex
product deoxycholate simple_molecule
reactant deoxycholate_Ext simple_molecule
mdtABCD-baeSR_mRNA MdtB
Name: mdtABCD-baeSR_mRNA -> MdtB
Description: Translation of MdtB
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtB
Components:
Function Name Type
product MdtB protein
reactant mdtABCD-baeSR_mRNA RNA
mdtABCD-baeSR_mRNA MdtC
Name: mdtABCD-baeSR_mRNA -> MdtC
Description: Translation of MdtC
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtC
Components:
Function Name Type
product MdtC protein
reactant mdtABCD-baeSR_mRNA RNA
mdtABCD-baeSR_mRNA MdtD
Name: mdtABCD-baeSR_mRNA -> MdtD
Description: Translation of MdtD
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtD
Components:
Function Name Type
product MdtD protein
reactant mdtABCD-baeSR_mRNA RNA
mdtABCD-baeSR_mRNA BaeS
Name: mdtABCD-baeSR_mRNA -> BaeS
Description: Translation of BaeS
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> BaeS
Components:
Function Name Type
product BaeS protein
reactant mdtABCD-baeSR_mRNA RNA
mdtABCD-baeSR_mRNA BaeR
Name: mdtABCD-baeSR_mRNA -> BaeR
Description: Translation of BaeR
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> BaeR
Components:
Function Name Type
product BaeR protein
reactant mdtABCD-baeSR_mRNA RNA



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