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BaeR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AcrA AcrD BaeR BaeS MdtA MdtB MdtC MdtD phosphate Spy TolC a drug a drug_Ext acrD acrD_mRNA mdtABCD-baeSR mdtABCD-baeSR_mRNA spy spy_mRNA BaeR phosphate AcrD AcrA TolC TolC MdtC MdtB MdtA chenodiol_Ext chenodiol


Gensor Unit       
Name: BaeR
Signal name: indole
zinc
flavonoids
sodium tungstate.
Classification:
Groups: GUs related to the two-component system
Gene Ontology Terms (GO): biological_process GO:1990507 - ATP-independent chaperone mediated protein folding
GO:0061077 - chaperone-mediated protein folding
GO:0046618 - drug export
GO:0006855 - drug transmembrane transport
GO:0018106 - peptidyl-histidine phosphorylation
GO:0000160 - phosphorelay signal transduction system
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cellular_component GO:0005829 - cytosol
GO:1990281 - efflux pump complex
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
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molecular_function GO:0003700 - DNA binding transcription factor activity
GO:0001216 - bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO:0000986 - bacterial-type proximal promoter sequence-specific DNA binding
GO:0015238 - drug transmembrane transporter activity
GO:0015307 - drug:proton antiporter activity
GO:0015562 - efflux transmembrane transporter activity
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (22 more...)
Function Name Type
protein AcrA protein
protein AcrD protein
complex AcrD-AcrA-TolC complex
protein BaeR protein
complex BaeR-phosphate complex
protein BaeS protein
protein MdtA protein
protein MdtB protein
protein MdtC protein
protein MdtD protein
protein Spy protein
protein TolC protein
complex TolC-MdtC-MdtB-MdtA complex
gene acrD gene
RNA acrD_mRNA RNA
simple_molecule drug simple_molecule
simple_molecule drug_Ext simple_molecule
gene mdtABCD-baeSR gene
RNA mdtABCD-baeSR_mRNA RNA
simple_molecule phosphate simple_molecule
gene spy gene
RNA spy_mRNA RNA


Reactions       
Showing 15 reactions
phosphate + BaeR BaeR-phosphate
Name: phosphate + BaeR -> BaeR-phosphate
Description: Reaction transforming phosphate, BaeR into BaeR-phosphate
Type: state transition
Pathway Components: phosphate + BaeR -> BaeR-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant BaeR protein nd nd
product BaeR-phosphate complex nd nd
reactant phosphate simple_molecule nd nd
BaeR-phosphate acrD acrD_mRNA
Name: acrD -> acrD_mRNA
Description: Transcription of transcription unit acrD. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: acrD - BaeR-phosphate -> acrD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator BaeR-phosphate complex nd nd
reactant acrD gene nd nd
product acrD_mRNA RNA nd nd
BaeR-phosphate mdtABCD-baeSR mdtABCD-baeSR_mRNA
Name: mdtABCD-baeSR -> mdtABCD-baeSR_mRNA
Description: Transcription of transcription unit mdtABCD-baeSR. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: mdtABCD-baeSR - BaeR-phosphate -> mdtABCD-baeSR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator BaeR-phosphate complex nd nd
reactant mdtABCD-baeSR gene nd nd
product mdtABCD-baeSR_mRNA RNA nd nd
BaeR-phosphate spy spy_mRNA
Name: spy -> spy_mRNA
Description: Transcription of transcription unit spy. Reaction activation by BaeR-phosphate.
Type: transcription
Pathway Components: spy - BaeR-phosphate -> spy_mRNA
Components:
Function Name Type Evidence Reference(s)
activator BaeR-phosphate complex nd nd
reactant spy gene nd nd
product spy_mRNA RNA nd nd
spy_mRNA Spy
Name: spy_mRNA -> Spy
Description: Translation of Spy
Type: translation
Pathway Components: spy_mRNA -> Spy
Components:
Function Name Type Evidence Reference(s)
product Spy protein nd nd
reactant spy_mRNA RNA nd nd
acrD_mRNA AcrD
Name: acrD_mRNA -> AcrD
Description: Translation of AcrD
Type: translation
Pathway Components: acrD_mRNA -> AcrD
Components:
Function Name Type Evidence Reference(s)
product AcrD protein nd nd
reactant acrD_mRNA RNA nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Pathway Components: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
reactant TolC protein nd nd
AcrD-AcrA-TolC TolC-MdtC-MdtB-MdtA drug_Ext drug
Name: drug_Ext -> drug
Description: Transport of drug_Ext through a bacterial membrane, leading to the presence of drug inside the cell.
Type: transport
Pathway Components: drug_Ext - AcrD-AcrA-TolC - TolC-MdtC-MdtB-MdtA -> drug
Components:
Function Name Type Evidence Reference(s)
catalyzer AcrD-AcrA-TolC complex nd nd
catalyzer TolC-MdtC-MdtB-MdtA complex nd nd
product drug simple_molecule nd nd
reactant drug_Ext simple_molecule nd nd
mdtABCD-baeSR_mRNA MdtA
Name: mdtABCD-baeSR_mRNA -> MdtA
Description: Translation of MdtA
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtA
Components:
Function Name Type Evidence Reference(s)
product MdtA protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd
MdtC + MdtA + MdtB + TolC TolC-MdtC-MdtB-MdtA
Name: MdtC + MdtA + MdtB + TolC -> TolC-MdtC-MdtB-MdtA
Description: Reaction transforming MdtC, MdtA, MdtB, TolC into TolC-MdtC-MdtB-MdtA
Type: state transition
Pathway Components: MdtC + MdtA + MdtB + TolC -> TolC-MdtC-MdtB-MdtA
Components:
Function Name Type Evidence Reference(s)
reactant MdtA protein nd nd
reactant MdtB protein nd nd
reactant MdtC protein nd nd
reactant TolC protein nd nd
product TolC-MdtC-MdtB-MdtA complex nd nd
mdtABCD-baeSR_mRNA MdtB
Name: mdtABCD-baeSR_mRNA -> MdtB
Description: Translation of MdtB
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtB
Components:
Function Name Type Evidence Reference(s)
product MdtB protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd
mdtABCD-baeSR_mRNA MdtC
Name: mdtABCD-baeSR_mRNA -> MdtC
Description: Translation of MdtC
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtC
Components:
Function Name Type Evidence Reference(s)
product MdtC protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd
mdtABCD-baeSR_mRNA MdtD
Name: mdtABCD-baeSR_mRNA -> MdtD
Description: Translation of MdtD
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> MdtD
Components:
Function Name Type Evidence Reference(s)
product MdtD protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd
mdtABCD-baeSR_mRNA BaeS
Name: mdtABCD-baeSR_mRNA -> BaeS
Description: Translation of BaeS
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> BaeS
Components:
Function Name Type Evidence Reference(s)
product BaeS protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd
mdtABCD-baeSR_mRNA BaeR
Name: mdtABCD-baeSR_mRNA -> BaeR
Description: Translation of BaeR
Type: translation
Pathway Components: mdtABCD-baeSR_mRNA -> BaeR
Components:
Function Name Type Evidence Reference(s)
product BaeR protein nd nd
reactant mdtABCD-baeSR_mRNA RNA nd nd



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