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AsnC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
5,10-methylenetetrahydrofolate dihydrofolate AsnA AsnC GDP GTP L-asparagine asp MioC MnmE MnmG a tRNA 2-thiouridine34 a 5-aminomethyl-2-thiouridine in tRNA a 5-carboxymethylaminomethyl-2-thiouridine in tRNA a 5-carboxymethylaminomethyluridine in tRNA a tRNA uridine34 ammonium asnA asnA_mRNA asnC asnC-mioC asnC-mioC-mnmG asnC-mioC-mnmG_mRNA asnC-mioC_mRNA asnC_mRNA PP glycine phosphate AsnC L-asparagine MnmE MnmG GDP phosphate GTP dihydrofolate


Gensor Unit       
Name: AsnC
Description: Molecular biology level
Detailed: In the absence of L-asparagine, AsnC negatively regulates its own expression and the expression of genes required for tRNA methylation and positively regulates the expression of genes required for L-asparagine biosynthesis. Under these conditions, AsnC remains unmodified, binds its target sites preventing its own expression and the expression of some of its regulated genes and at other promoters enabling the expression of its regulated gene.
Less detailed: In the absence of L-asparagine, AsnC negatively regulates the expression of genes needed for tRNA methylation and positively regulates the expression of genes necessary for L-asparagine biosynthesis.

Physiology level
Detailed: The presence of L-asparagine induces the expression of genes involved with tRNA methylation and inhibits the expression of genes required for L-asparagine biosynthesis. Under this condition the genes necessary for modification of tRNA uridine to tRNA methyl uridine are expressed, and the genes necessary for conversion of L-aspartate to L-asparagine are not expressed.
Less detailed: The presence of L-asparagine induces the expression of genes needful for modification of uridine tRNA to methyl uridine tRNA, and inhibits the expression of genes required for conversion of L-aspartate to L-asparagine.
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): biological_process GO:0006529 - asparagine biosynthetic process
GO:0009102 - biotin biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0005524 - ATP binding
GO:0003700 - DNA binding transcription factor activity
GO:0010181 - FMN binding
GO:0016597 - amino acid binding
GO:0004071 - aspartate-ammonia ligase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0016874 - ligase activity
Read more >
Components: Show/Hide Components Table (39 more...)
Function Name Type
simple_molecule 5-aminomethyl-2-thiouridine in tRNA simple_molecule
simple_molecule 5-carboxymethylaminomethyl-2-thiouridine in tRNA simple_molecule
simple_molecule 5-carboxymethylaminomethyluridine in tRNA simple_molecule
simple_molecule 7,8-dihydrofolate simple_molecule
simple_molecule A(H2) simple_molecule
protein AsnA protein
protein AsnC protein
complex AsnC-asparagine complex
protein MioC protein
protein MnmE protein
complex MnmE-MnmG complex
protein MnmG protein
simple_molecule N7-methylguanine527 in 16S rRNA simple_molecule
protein RsmG protein
simple_molecule SAM simple_molecule
simple_molecule acceptors simple_molecule
simple_molecule adenosylhomocysteine simple_molecule
simple_molecule ammonium simple_molecule
gene asnA gene
RNA asnA_mRNA RNA
gene asnC gene
gene asnC-mioC gene
gene asnC-mioC-mnmG gene
gene asnC-mioC-mnmG-rsmG gene
RNA asnC-mioC-mnmG-rsmG_mRNA RNA
RNA asnC-mioC-mnmG_mRNA RNA
RNA asnC-mioC_mRNA RNA
RNA asnC_mRNA RNA
simple_molecule asparagine simple_molecule
simple_molecule aspartate simple_molecule
simple_molecule diphosphate simple_molecule
simple_molecule glycine simple_molecule
simple_molecule guanine527 in 16S rRNA simple_molecule
simple_molecule guanosine-diphosphate simple_molecule
simple_molecule guanosine-triphosphate simple_molecule
simple_molecule methylene-H4PteGlu(n) simple_molecule
simple_molecule phosphate simple_molecule
simple_molecule tRNA 2-thiouridine34 simple_molecule
simple_molecule tRNA uridine34 simple_molecule


Reactions       
Showing 23 reactions
AsnC asnA asnA_mRNA
Name: asnA -> asnA_mRNA
Description: Transcription of transcription unit asnA. Reaction activation by AsnC.
Type: transcription
Pathway Components: asnA - AsnC -> asnA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator AsnC protein nd nd
reactant asnA gene nd nd
product asnA_mRNA RNA nd nd
AsnC asnC-mioC-mnmG-rsmG asnC-mioC-mnmG-rsmG_mRNA
Name: asnC-mioC-mnmG-rsmG -> asnC-mioC-mnmG-rsmG_mRNA
Description: Transcription of transcription unit asnC-mioC-mnmG-rsmG. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC-mioC-mnmG-rsmG - AsnC -> asnC-mioC-mnmG-rsmG_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AsnC protein nd nd
reactant asnC-mioC-mnmG-rsmG gene nd nd
product asnC-mioC-mnmG-rsmG_mRNA RNA nd nd
asparagine + AsnC AsnC-asparagine
Name: asparagine + AsnC -> AsnC-asparagine
Description: Reaction transforming asparagine, AsnC into AsnC-asparagine
Type: state transition
Pathway Components: asparagine + AsnC -> AsnC-asparagine
Components:
Function Name Type Evidence Reference(s)
reactant AsnC protein nd nd
product AsnC-asparagine complex nd nd
reactant asparagine simple_molecule nd nd
AsnC asnC asnC_mRNA
Name: asnC -> asnC_mRNA
Description: Transcription of transcription unit asnC. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC - AsnC -> asnC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AsnC protein nd nd
reactant asnC gene nd nd
product asnC_mRNA RNA nd nd
AsnC asnC-mioC asnC-mioC_mRNA
Name: asnC-mioC -> asnC-mioC_mRNA
Description: Transcription of transcription unit asnC-mioC. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC-mioC - AsnC -> asnC-mioC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AsnC protein nd nd
reactant asnC-mioC gene nd nd
product asnC-mioC_mRNA RNA nd nd
AsnC asnC-mioC-mnmG asnC-mioC-mnmG_mRNA
Name: asnC-mioC-mnmG -> asnC-mioC-mnmG_mRNA
Description: Transcription of transcription unit asnC-mioC-mnmG. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC-mioC-mnmG - AsnC -> asnC-mioC-mnmG_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AsnC protein nd nd
reactant asnC-mioC-mnmG gene nd nd
product asnC-mioC-mnmG_mRNA RNA nd nd
asnC-mioC-mnmG-rsmG_mRNA AsnC
Name: asnC-mioC-mnmG-rsmG_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC-mioC-mnmG-rsmG_mRNA -> AsnC
Components:
Function Name Type Evidence Reference(s)
product AsnC protein nd nd
reactant asnC-mioC-mnmG-rsmG_mRNA RNA nd nd
asnC-mioC-mnmG-rsmG_mRNA MioC
Name: asnC-mioC-mnmG-rsmG_mRNA -> MioC
Description: Translation of MioC
Type: translation
Pathway Components: asnC-mioC-mnmG-rsmG_mRNA -> MioC
Components:
Function Name Type Evidence Reference(s)
product MioC protein nd nd
reactant asnC-mioC-mnmG-rsmG_mRNA RNA nd nd
asnC-mioC-mnmG-rsmG_mRNA MnmG
Name: asnC-mioC-mnmG-rsmG_mRNA -> MnmG
Description: Translation of MnmG
Type: translation
Pathway Components: asnC-mioC-mnmG-rsmG_mRNA -> MnmG
Components:
Function Name Type Evidence Reference(s)
product MnmG protein nd nd
reactant asnC-mioC-mnmG-rsmG_mRNA RNA nd nd
MnmG + MnmE MnmE-MnmG
Name: MnmG + MnmE -> MnmE-MnmG
Description: Reaction transforming MnmG, MnmE into MnmE-MnmG
Type: state transition
Pathway Components: MnmG + MnmE -> MnmE-MnmG
Components:
Function Name Type Evidence Reference(s)
reactant MnmE protein nd nd
product MnmE-MnmG complex nd nd
reactant MnmG protein nd nd
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA uridine34 + acceptors + glycine -> 5-carboxymethylaminomethyluridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA uridine34, acceptors, glycine into 5-carboxymethylaminomethyluridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate , A(H2)
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA uridine34 + acceptors + glycine - MnmE-MnmG -> 5-carboxymethylaminomethyluridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Components: Show/Hide Components Table
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + glycine -> 5-carboxymethylaminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA 2-thiouridine34, glycine into 5-carboxymethylaminomethyl-2-thiouridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + glycine - MnmE-MnmG -> 5-carboxymethylaminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Components: Show/Hide Components Table
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + ammonium -> 5-aminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA 2-thiouridine34, ammonium into 5-aminomethyl-2-thiouridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + ammonium - MnmE-MnmG -> 5-aminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Components: Show/Hide Components Table
asnC-mioC-mnmG-rsmG_mRNA RsmG
Name: asnC-mioC-mnmG-rsmG_mRNA -> RsmG
Description: Translation of RsmG
Type: translation
Pathway Components: asnC-mioC-mnmG-rsmG_mRNA -> RsmG
Components:
Function Name Type Evidence Reference(s)
product RsmG protein nd nd
reactant asnC-mioC-mnmG-rsmG_mRNA RNA nd nd
RsmG guanine527 in 16S rRNA + SAM Products
Name: guanine527 in 16S rRNA + SAM -> N7-methylguanine527 in 16S rRNA + adenosylhomocysteine
Description: Reaction transforming guanine527 in 16S rRNA, SAM into N7-methylguanine527 in 16S rRNA, adenosylhomocysteine
Type: state transition
Pathway Components: guanine527 in 16S rRNA + SAM - RsmG -> N7-methylguanine527 in 16S rRNA + adenosylhomocysteine
Components:
Function Name Type Evidence Reference(s)
product N7-methylguanine527 in 16S rRNA simple_molecule nd nd
catalyzer RsmG protein nd nd
reactant SAM simple_molecule nd nd
product adenosylhomocysteine simple_molecule nd nd
reactant guanine527 in 16S rRNA simple_molecule nd nd
asnC_mRNA AsnC
Name: asnC_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC_mRNA -> AsnC
Components:
Function Name Type Evidence Reference(s)
product AsnC protein nd nd
reactant asnC_mRNA RNA nd nd
asnC-mioC-mnmG_mRNA AsnC
Name: asnC-mioC-mnmG_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> AsnC
Components:
Function Name Type Evidence Reference(s)
product AsnC protein nd nd
reactant asnC-mioC-mnmG_mRNA RNA nd nd
asnC-mioC-mnmG_mRNA MioC
Name: asnC-mioC-mnmG_mRNA -> MioC
Description: Translation of MioC
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> MioC
Components:
Function Name Type Evidence Reference(s)
product MioC protein nd nd
reactant asnC-mioC-mnmG_mRNA RNA nd nd
asnC-mioC-mnmG_mRNA MnmG
Name: asnC-mioC-mnmG_mRNA -> MnmG
Description: Translation of MnmG
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> MnmG
Components:
Function Name Type Evidence Reference(s)
product MnmG protein nd nd
reactant asnC-mioC-mnmG_mRNA RNA nd nd
asnA_mRNA AsnA
Name: asnA_mRNA -> AsnA
Description: Translation of AsnA
Type: translation
Pathway Components: asnA_mRNA -> AsnA
Components:
Function Name Type Evidence Reference(s)
product AsnA protein nd nd
reactant asnA_mRNA RNA nd nd
AsnA asparagine aspartate + ammonium diphosphate + asparagine
Name: aspartate + ammonium -> diphosphate + asparagine
Description: Reaction transforming aspartate, ammonium into diphosphate, asparagine
Type: state transition
Pathway Components: aspartate + ammonium - AsnA - asparagine -> diphosphate + asparagine
Components:
Function Name Type Evidence Reference(s)
catalyzer AsnA protein nd nd
reactant ammonium simple_molecule nd nd
inhibitor asparagine simple_molecule nd nd
product asparagine simple_molecule nd nd
reactant aspartate simple_molecule nd nd
product diphosphate simple_molecule nd nd
asnC-mioC_mRNA AsnC
Name: asnC-mioC_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC-mioC_mRNA -> AsnC
Components:
Function Name Type Evidence Reference(s)
product AsnC protein nd nd
reactant asnC-mioC_mRNA RNA nd nd
asnC-mioC_mRNA MioC
Name: asnC-mioC_mRNA -> MioC
Description: Translation of MioC
Type: translation
Pathway Components: asnC-mioC_mRNA -> MioC
Components:
Function Name Type Evidence Reference(s)
product MioC protein nd nd
reactant asnC-mioC_mRNA RNA nd nd



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