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ArsR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Antimonite ArsB ArsC ArsR reduced glutaredoxin oxidized glutaredoxin arsRBC arsRBC_mRNA arsenate arsenite arsenite_Ext ArsR Antimonite ArsR arsenite


Gensor Unit       
Name: ArsR
Description: ArsR negatively regulates the expression of genes involved in detoxification of arsenic-containing substances in the absence of arsenite and antimonite. The presence of arsenite or antimonite induces the expression of genes related to the reduction of arsenate to arsenite and to arsenite efllux.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0015699 - antimonite transport
GO:0008794 - arsenate reductase (glutaredoxin) activity
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0016491 - oxidoreductase activity
GO:0016020 - membrane
GO:0005622 - intracellular
GO:0005887 - integral component of plasma membrane
GO:0003677 - DNA binding
GO:0046685 - response to arsenic-containing substance
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
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Components:
Function Name Type
simple molecule arsenite simple molecule


Reactions       
Showing 6 reactions
arsRBC arsRBC_mRNA
Name: arsRBC -> arsRBC_mRNA
Description: Transcription of transcription unit arsRBC; reaction inhibition by ArsR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant arsRBC operon nd nd
product arsRBC_mRNA RNA nd nd
antimonite ion + ArsR ArsR-antimonite ion
Name: antimonite ion + ArsR -> ArsR-antimonite ion
Description: Reaction transforming antimonite ion, ArsR into ArsR-antimonite ion
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product ArsR-antimonite ion complex nd nd
reactant ArsR protein nd nd
reactant antimonite ion simple molecule nd nd
arsenite + ArsR ArsR-arsenite
Name: arsenite + ArsR -> ArsR-arsenite
Description: Reaction transforming arsenite, ArsR into ArsR-arsenite
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant arsenite simple molecule nd nd
reactant ArsR protein nd nd
product ArsR-arsenite complex nd nd
arsRBC_mRNA ArsR
Name: arsRBC_mRNA -> ArsR
Description: Translation of ArsR
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant arsRBC_mRNA RNA nd nd
product ArsR protein nd nd
arsRBC_mRNA ArsB
Name: arsRBC_mRNA -> ArsB
Description: Translation of ArsB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product arsRBC_mRNA RNA nd nd
reactant arsRBC_mRNA RNA nd nd
arsRBC_mRNA ArsC
Name: arsRBC_mRNA -> ArsC
Description: Translation of ArsC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant arsRBC_mRNA RNA nd nd
product arsRBC_mRNA RNA nd nd



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