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ArsR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Antimonite ArsB ArsC ArsR reduced glutaredoxin oxidized glutaredoxin arsRBC arsRBC_mRNA arsenate arsenite arsenite_Ext ArsR Antimonite ArsR arsenite


Gensor Unit       
Name: ArsR
Description: Molecular biology level
Detailed: In absence of arsenite and antimonite ArsR negatively regulates the expression of genes required for reduction from arsenate to arsenite, arsenite efflux and its own expression. Under this condition, ArsR binds its target sites preventing/avoiding/hindering its own expression and the expression of its regulated genes. In the presence of arsenite or antimonite, ArsR is modified to ArsR-arsenite or ArsR-antimonite, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In absence of arsenite and antimonite, ArsR negatively regulates the expression of genes needed for detoxification of arsenic containing substances and its own expression.

Physiology level
Detailed: The presence of arsenite or antimonite induces the expression of genes involved with the detoxification of arsenic containing substances. Under this condition the genes necessary for arsenate reduction to arsenite and arsenite and its efflux are expressed.
Less detailed: The presence of arsenite or antimonite induces the expression of genes needful for the reduction from arsenate to arsenite and arsenite efflux.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0015699 - antimonite transport
GO:0015700 - arsenite transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006355 - regulation of transcription, DNA-templated
GO:0046685 - response to arsenic-containing substance
GO:0006351 - transcription, DNA-templated
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cellular_component GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0022804 - active transmembrane transporter activity
GO:0042960 - antimonite secondary active transmembrane transporter activity
GO:0008794 - arsenate reductase (glutaredoxin) activity
GO:0008490 - arsenite secondary active transmembrane transporter activity
GO:0015105 - arsenite transmembrane transporter activity
GO:0044212 - transcription regulatory region DNA binding
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Components: Show/Hide Components Table (13 more...)
Function Name Type
protein ArsB protein
protein ArsC protein
protein ArsR protein
complex ArsR-antimonite ion complex
complex ArsR-arsenite complex
simple_molecule antimonite ion simple_molecule
gene arsRBC gene
RNA arsRBC_mRNA RNA
simple_molecule arsenate simple_molecule
simple_molecule arsenite simple_molecule
simple_molecule arsenite_Ext simple_molecule
simple_molecule oxidized glutaredoxin simple_molecule
simple_molecule reduced glutaredoxin simple_molecule


Reactions       
Showing 8 reactions
ArsR arsRBC arsRBC_mRNA
Name: arsRBC -> arsRBC_mRNA
Description: Transcription of transcription unit arsRBC. Reaction inhibition by ArsR.
Type: transcription
Pathway Components: arsRBC - ArsR -> arsRBC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor ArsR protein nd nd
reactant arsRBC gene nd nd
product arsRBC_mRNA RNA nd nd
antimonite ion + ArsR ArsR-antimonite ion
Name: antimonite ion + ArsR -> ArsR-antimonite ion
Description: Reaction transforming antimonite ion, ArsR into ArsR-antimonite ion
Type: state transition
Pathway Components: antimonite ion + ArsR -> ArsR-antimonite ion
Components:
Function Name Type Evidence Reference(s)
reactant ArsR protein nd nd
product ArsR-antimonite ion complex nd nd
reactant antimonite ion simple_molecule nd nd
arsenite + ArsR ArsR-arsenite
Name: arsenite + ArsR -> ArsR-arsenite
Description: Reaction transforming arsenite, ArsR into ArsR-arsenite
Type: state transition
Pathway Components: arsenite + ArsR -> ArsR-arsenite
Components:
Function Name Type Evidence Reference(s)
reactant ArsR protein nd nd
product ArsR-arsenite complex nd nd
reactant arsenite simple_molecule nd nd
arsRBC_mRNA ArsR
Name: arsRBC_mRNA -> ArsR
Description: Translation of ArsR
Type: translation
Pathway Components: arsRBC_mRNA -> ArsR
Components:
Function Name Type Evidence Reference(s)
product ArsR protein nd nd
reactant arsRBC_mRNA RNA nd nd
arsRBC_mRNA ArsB
Name: arsRBC_mRNA -> ArsB
Description: Translation of ArsB
Type: translation
Pathway Components: arsRBC_mRNA -> ArsB
Components:
Function Name Type Evidence Reference(s)
product ArsB protein nd nd
reactant arsRBC_mRNA RNA nd nd
ArsB arsenite_Ext arsenite
Name: arsenite_Ext -> arsenite
Description: Transport of arsenite_Ext through a bacterial membrane, leading to the presence of arsenite inside the cell.
Type: transport
Pathway Components: arsenite_Ext - ArsB -> arsenite
Components:
Function Name Type Evidence Reference(s)
catalyzer ArsB protein nd nd
product arsenite simple_molecule nd nd
reactant arsenite_Ext simple_molecule nd nd
arsRBC_mRNA ArsC
Name: arsRBC_mRNA -> ArsC
Description: Translation of ArsC
Type: translation
Pathway Components: arsRBC_mRNA -> ArsC
Components:
Function Name Type Evidence Reference(s)
product ArsC protein nd nd
reactant arsRBC_mRNA RNA nd nd
ArsC reduced glutaredoxin + arsenate oxidized glutaredoxin + arsenite
Name: reduced glutaredoxin + arsenate -> oxidized glutaredoxin + arsenite
Description: Reaction transforming reduced glutaredoxin, arsenate into oxidized glutaredoxin, arsenite
Type: state transition
Pathway Components: reduced glutaredoxin + arsenate - ArsC -> oxidized glutaredoxin + arsenite
Components:
Function Name Type Evidence Reference(s)
catalyzer ArsC protein nd nd
reactant arsenate simple_molecule nd nd
product arsenite simple_molecule nd nd
product oxidized glutaredoxin simple_molecule nd nd
reactant reduced glutaredoxin simple_molecule nd nd



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