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AlsR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: AlsR
Description: Molecular biology level
Detailed: In the absence of D-allose, AlsR negatively regulates the expression of genes required for D-allose importing and catabolic process. Under this condition, AlsR binds its target sites preventing its own expression and the expression of its regulated genes. In the presence of D-allose, AlsR is modified to AlsR-D-allose, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In the absence of D-allose, AlsR negatively regulates the expression of genes needed for D-allose importing and catabolic process.

Physiology level
Detailed: The presence of D-allose induces the expression of genes involved with D-allose uptake and assimilation. Under this condition the genes necessary for D-allose uptake and degradation to D-fructuose-6-phosphate (a substrate for glycolysis), are expressed.
Less detailed: The presence of D-allose induces the expression of genes needful for D-allose uptake and degradation to D-fructuose-6-phosphate (which feeds the glycolysis).
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0019316 - D-allose catabolic process
GO:0015754 - allose transmembrane transport
GO:1901135 - carbohydrate derivative metabolic process
GO:0008643 - carbohydrate transport
GO:0044262 - cellular carbohydrate metabolic process
GO:0006096 - glycolytic process
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cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
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molecular_function GO:0005524 - ATP binding
GO:0003700 - DNA binding transcription factor activity
GO:0008786 - allose 6-phosphate isomerase activity
GO:0015593 - allose transmembrane transporter activity
GO:0034700 - allulose 6-phosphate 3-epimerase activity
GO:0097367 - carbohydrate derivative binding
GO:0004340 - glucokinase activity
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Components: Show/Hide Components Table (20 more...)
Function Name Type
protein AlsA protein
complex AlsA-AlsC-AlsB complex
protein AlsB protein
protein AlsC protein
protein AlsE protein
protein AlsR protein
complex AlsR-allose complex
protein RpiB protein
protein RpiR protein
simple_molecule aldehydo-D-allose-6-P simple_molecule
simple_molecule allose simple_molecule
simple_molecule allose_Ext simple_molecule
simple_molecule allulose-6-P simple_molecule
simple_molecule fructose-6-P simple_molecule
simple_molecule ribose-5P simple_molecule
simple_molecule ribulose-5P simple_molecule
gene rpiB gene
RNA rpiB_mRNA RNA
gene rpiR-alsBACE gene
RNA rpiR-alsBACE_mRNA RNA


Reactions       
Showing 14 reactions
AlsR rpiB rpiB_mRNA
Name: rpiB -> rpiB_mRNA
Description: Transcription of transcription unit rpiB. Reaction inhibition by AlsR.
Type: transcription
Pathway Components: rpiB - AlsR -> rpiB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AlsR protein nd nd
reactant rpiB gene nd nd
product rpiB_mRNA RNA nd nd
AlsR rpiR-alsBACE rpiR-alsBACE_mRNA
Name: rpiR-alsBACE -> rpiR-alsBACE_mRNA
Description: Transcription of transcription unit rpiR-alsBACE. Reaction inhibition by AlsR.
Type: transcription
Pathway Components: rpiR-alsBACE - AlsR -> rpiR-alsBACE_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor AlsR protein nd nd
reactant rpiR-alsBACE gene nd nd
product rpiR-alsBACE_mRNA RNA nd nd
allose + AlsR AlsR-allose
Name: allose + AlsR -> AlsR-allose
Description: Reaction transforming allose, AlsR into AlsR-allose
Type: state transition
Pathway Components: allose + AlsR -> AlsR-allose
Components:
Function Name Type Evidence Reference(s)
reactant AlsR protein nd nd
product AlsR-allose complex nd nd
reactant allose simple_molecule nd nd
rpiR-alsBACE_mRNA RpiR
Name: rpiR-alsBACE_mRNA -> RpiR
Description: Translation of RpiR
Type: translation
Pathway Components: rpiR-alsBACE_mRNA -> RpiR
Components:
Function Name Type Evidence Reference(s)
product RpiR protein nd nd
reactant rpiR-alsBACE_mRNA RNA nd nd
rpiR-alsBACE_mRNA AlsB
Name: rpiR-alsBACE_mRNA -> AlsB
Description: Translation of AlsB
Type: translation
Pathway Components: rpiR-alsBACE_mRNA -> AlsB
Components:
Function Name Type Evidence Reference(s)
product AlsB protein nd nd
reactant rpiR-alsBACE_mRNA RNA nd nd
AlsB + AlsA + AlsC AlsA-AlsC-AlsB
Name: AlsB + AlsA + AlsC -> AlsA-AlsC-AlsB
Description: Reaction transforming AlsB, AlsA, AlsC into AlsA-AlsC-AlsB
Type: state transition
Pathway Components: AlsB + AlsA + AlsC -> AlsA-AlsC-AlsB
Components:
Function Name Type Evidence Reference(s)
reactant AlsA protein nd nd
product AlsA-AlsC-AlsB complex nd nd
reactant AlsB protein nd nd
reactant AlsC protein nd nd
AlsA-AlsC-AlsB allose_Ext allose
Name: allose_Ext -> allose
Description: Transport of allose_Ext through a bacterial membrane, leading to the presence of allose inside the cell.
Type: transport
Pathway Components: allose_Ext - AlsA-AlsC-AlsB -> allose
Components:
Function Name Type Evidence Reference(s)
catalyzer AlsA-AlsC-AlsB complex nd nd
product allose simple_molecule nd nd
reactant allose_Ext simple_molecule nd nd
rpiR-alsBACE_mRNA AlsA
Name: rpiR-alsBACE_mRNA -> AlsA
Description: Translation of AlsA
Type: translation
Pathway Components: rpiR-alsBACE_mRNA -> AlsA
Components:
Function Name Type Evidence Reference(s)
product AlsA protein nd nd
reactant rpiR-alsBACE_mRNA RNA nd nd
rpiR-alsBACE_mRNA AlsC
Name: rpiR-alsBACE_mRNA -> AlsC
Description: Translation of AlsC
Type: translation
Pathway Components: rpiR-alsBACE_mRNA -> AlsC
Components:
Function Name Type Evidence Reference(s)
product AlsC protein nd nd
reactant rpiR-alsBACE_mRNA RNA nd nd
rpiR-alsBACE_mRNA AlsE
Name: rpiR-alsBACE_mRNA -> AlsE
Description: Translation of AlsE
Type: translation
Pathway Components: rpiR-alsBACE_mRNA -> AlsE
Components:
Function Name Type Evidence Reference(s)
product AlsE protein nd nd
reactant rpiR-alsBACE_mRNA RNA nd nd
AlsE allulose-6-P fructose-6-P
Name: allulose-6-P -> fructose-6-P
Description: Reaction transforming allulose-6-P into fructose-6-P
Type: state transition
Pathway Components: allulose-6-P - AlsE -> fructose-6-P
Components:
Function Name Type Evidence Reference(s)
catalyzer AlsE protein nd nd
reactant allulose-6-P simple_molecule nd nd
product fructose-6-P simple_molecule nd nd
rpiB_mRNA RpiB
Name: rpiB_mRNA -> RpiB
Description: Translation of RpiB
Type: translation
Pathway Components: rpiB_mRNA -> RpiB
Components:
Function Name Type Evidence Reference(s)
product RpiB protein nd nd
reactant rpiB_mRNA RNA nd nd
RpiB aldehydo-D-allose-6-P allulose-6-P
Name: aldehydo-D-allose-6-P -> allulose-6-P
Description: Reaction transforming aldehydo-D-allose-6-P into allulose-6-P
Type: state transition
Pathway Components: aldehydo-D-allose-6-P - RpiB -> allulose-6-P
Components:
Function Name Type Evidence Reference(s)
catalyzer RpiB protein nd nd
reactant aldehydo-D-allose-6-P simple_molecule nd nd
product allulose-6-P simple_molecule nd nd
RpiB ribose-5P ribulose-5P
Name: ribose-5P -> ribulose-5P
Description: Reaction transforming ribose-5P into ribulose-5P
Type: state transition
Pathway Components: ribose-5P - RpiB -> ribulose-5P
Components:
Function Name Type Evidence Reference(s)
catalyzer RpiB protein nd nd
reactant ribose-5P simple_molecule nd nd
product ribulose-5P simple_molecule nd nd



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