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AllS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AllC AllD AllE AllS CO2 (S)-ureidoglycolate (S)-ureidoglycine allDCE allDCE_mRNA allantoate (S)-allantoin ammonia oxalurate AllS (S)-allantoin


Gensor Unit       
Name: AllS
Description: Molecular biology level
Detailed: In the presence of (S)-allantoin, AllS positively regulates the expression of genes required for allantoin assimilation. Under this condition, AllS is modified to AllS-(S)-allantoin, binds to its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of (S)-allantoin, Alls positively regulates the expression of genes needed for allantoin assimilation.

Physiology level
Detailed: The presence of allantoin induces the expression of genes involved with allantoin assimilation. Under this condition the genes necessary for allantoin degradation to oxalurate with ammonium production are expressed (or induced).
Less detailed: The presence of (S)-allantoin induces the expression of genes needful for allantoin degradation to oxalurate with ammonium production throughout to the process.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0009442 - allantoin assimilation pathway
molecular_function GO:0047652 - allantoate deiminase activity
GO:0030145 - manganese ion binding
GO:0071522 - ureidoglycine aminohydrolase activity
GO:0009040 - ureidoglycolate dehydrogenase activity
Components: Show/Hide Components Table (14 more...)
Function Name Type
simple_molecule (S)-2-ureidoglycine simple_molecule
protein AllC protein
protein AllD protein
protein AllE protein
protein AllS protein
complex AllS-allantoin complex
simple_molecule CO2 simple_molecule
gene allDCE gene
RNA allDCE_mRNA RNA
simple_molecule allantoate simple_molecule
simple_molecule allantoin simple_molecule
simple_molecule ammonium simple_molecule
simple_molecule oxalurate simple_molecule
simple_molecule ureidoglycolate simple_molecule


Reactions       
Showing 9 reactions
allantoin + AllS AllS-allantoin
Name: allantoin + AllS -> AllS-allantoin
Description: Reaction transforming allantoin, AllS into AllS-allantoin
Type: state transition
Pathway Components: allantoin + AllS -> AllS-allantoin
Components:
Function Name Type Evidence Reference(s)
reactant AllS protein nd nd
product AllS-allantoin complex nd nd
reactant allantoin simple_molecule nd nd
AllS-allantoin allDCE allDCE_mRNA
Name: allDCE -> allDCE_mRNA
Description: Transcription of transcription unit allDCE. Reaction activation by AllS-allantoin.
Type: transcription
Pathway Components: allDCE - AllS-allantoin -> allDCE_mRNA
Components:
Function Name Type Evidence Reference(s)
activator AllS-allantoin complex nd nd
reactant allDCE gene nd nd
product allDCE_mRNA RNA nd nd
allDCE_mRNA AllD
Name: allDCE_mRNA -> AllD
Description: Translation of AllD
Type: translation
Pathway Components: allDCE_mRNA -> AllD
Components:
Function Name Type Evidence Reference(s)
product AllD protein nd nd
reactant allDCE_mRNA RNA nd nd
AllD ureidoglycolate oxalurate
Name: ureidoglycolate -> oxalurate
Description: Reaction transforming ureidoglycolate into oxalurate
Type: state transition
Pathway Components: ureidoglycolate - AllD -> oxalurate
Components:
Function Name Type Evidence Reference(s)
catalyzer AllD protein nd nd
product oxalurate simple_molecule nd nd
reactant ureidoglycolate simple_molecule nd nd
allDCE_mRNA AllC
Name: allDCE_mRNA -> AllC
Description: Translation of AllC
Type: translation
Pathway Components: allDCE_mRNA -> AllC
Components:
Function Name Type Evidence Reference(s)
product AllC protein nd nd
reactant allDCE_mRNA RNA nd nd
AllC allantoate (S)-2-ureidoglycine + ammonium + CO2
Name: allantoate -> (S)-2-ureidoglycine + ammonium + CO2
Description: Reaction transforming allantoate into (S)-2-ureidoglycine, ammonium , CO2
Type: state transition
Pathway Components: allantoate - AllC -> (S)-2-ureidoglycine + ammonium + CO2
Components:
Function Name Type Evidence Reference(s)
product (S)-2-ureidoglycine simple_molecule nd nd
catalyzer AllC protein nd nd
product CO2 simple_molecule nd nd
reactant allantoate simple_molecule nd nd
product ammonium simple_molecule nd nd
allDCE_mRNA AllE
Name: allDCE_mRNA -> AllE
Description: Translation of AllE
Type: translation
Pathway Components: allDCE_mRNA -> AllE
Components:
Function Name Type Evidence Reference(s)
product AllE protein nd nd
reactant allDCE_mRNA RNA nd nd
AllE (S)-2-ureidoglycine ureidoglycolate + ammonium
Name: (S)-2-ureidoglycine -> ureidoglycolate + ammonium
Description: Reaction transforming (S)-2-ureidoglycine into ureidoglycolate, ammonium
Type: state transition
Pathway Components: (S)-2-ureidoglycine - AllE -> ureidoglycolate + ammonium
Components:
Function Name Type Evidence Reference(s)
reactant (S)-2-ureidoglycine simple_molecule nd nd
catalyzer AllE protein nd nd
product ammonium simple_molecule nd nd
product ureidoglycolate simple_molecule nd nd
allantoin allantoate
Name: allantoin -> allantoate
Description: Transformation of allantoin into allantoate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: allantoin / allantoate
Components:
Function Name Type Evidence Reference(s)
product allantoate simple_molecule nd nd
reactant allantoin simple_molecule nd nd



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