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AcrR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AcrA AcrB AcrD AcrR ethidium This Gensor Unit is not yet available Proflavin R6G TolC a drug a drug_Ext acrAB acrAB_mRNA acrR acrR_mRNA micF micF_mRNA AcrR ethidium AcrR R6G AcrR Proflavin AcrA TolC AcrB AcrD AcrA TolC


Gensor Unit       
Name: AcrR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0016020 - membrane
GO:0005887 - integral component of plasma membrane
GO:0055085 - transmembrane transport
GO:0046677 - response to antibiotic
GO:0003677 - DNA binding
GO:0015238 - drug transmembrane transporter activity
GO:0006855 - drug transmembrane transport
GO:0042802 - identical protein binding
GO:0005886 - plasma membrane
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Components:
Function Name Type
RNA micF_mRNA RNA


Reactions       
Showing 13 reactions
acrAB acrAB_mRNA
Name: acrAB -> acrAB_mRNA
Description: Transcription of transcription unit acrAB; reaction inhibition by AcrR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant acrAB gene nd nd
product acrAB_mRNA RNA nd nd
acrR acrR_mRNA
Name: acrR -> acrR_mRNA
Description: Transcription of transcription unit acrR; reaction inhibition by AcrR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product acrR_mRNA RNA nd nd
reactant acrR gene nd nd
micF micF_mRNA
Name: micF -> micF_mRNA
Description: Transcription of transcription unit micF; reaction activation by HU.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product micF_mRNA RNA nd nd
reactant micF gene nd nd
AcrR + ethidium AcrR-ethidium
Name: AcrR + ethidium -> AcrR-ethidium
Description: Reaction transforming AcrR, ethidium into AcrR-ethidium
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant ethidium simple molecule nd nd
reactant AcrR protein nd nd
product AcrR-ethidium complex nd nd
AcrR + R6G AcrR-R6G
Name: AcrR + R6G -> AcrR-R6G
Description: Reaction transforming AcrR, R6G into AcrR-R6G
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product AcrR-R6G complex nd nd
reactant AcrR protein nd nd
reactant R6G simple molecule nd nd
AcrR + Proflavin AcrR-Proflavin
Name: AcrR + Proflavin -> AcrR-Proflavin
Description: Reaction transforming AcrR, Proflavin into AcrR-Proflavin
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant Proflavin simple molecule nd nd
reactant AcrR protein nd nd
product AcrR-Proflavin complex nd nd
acrR_mRNA AcrR
Name: acrR_mRNA -> AcrR
Description: Translation of AcrR
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AcrR protein nd nd
reactant acrR_mRNA RNA nd nd
acrAB_mRNA AcrA
Name: acrAB_mRNA -> AcrA
Description: Translation of AcrA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant acrAB_mRNA RNA nd nd
product AcrA protein nd nd
AcrA + TolC + AcrB AcrA-TolC-AcrB
Name: AcrA + TolC + AcrB -> AcrA-TolC-AcrB
Description: Reaction transforming AcrA, TolC, AcrB into AcrA-TolC-AcrB
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product AcrA-TolC-AcrB complex nd nd
reactant AcrB protein nd nd
reactant AcrA protein nd nd
reactant TolC protein nd nd
a drug_Ext a drug
Name: a drug_Ext -> a drug
Description: Transport of a drug_Ext through a bacterial membrane, leading to the presence of a drug inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant a drug_Ext simple molecule nd nd
product a drug simple molecule nd nd
AcrD + AcrA + TolC AcrD-AcrA-TolC
Name: AcrD + AcrA + TolC -> AcrD-AcrA-TolC
Description: Reaction transforming AcrD, AcrA, TolC into AcrD-AcrA-TolC
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant AcrA protein nd nd
reactant TolC protein nd nd
reactant AcrD protein nd nd
product AcrD-AcrA-TolC complex nd nd
micF_mRNA MicF small regulatory RNA
Name: micF_mRNA -> MicF small regulatory RNA
Description: Translation of MicF small regulatory RNA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant micF_mRNA RNA nd nd
product MicF small regulatory RNA RNA nd nd
acrAB_mRNA AcrB
Name: acrAB_mRNA -> AcrB
Description: Translation of AcrB
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant acrAB_mRNA RNA nd nd
product AcrB protein nd nd



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