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Ada Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
1-ethyladenine ketoglutarate 3-methylcrotonyl-CoA Ada AidB AlkA AlkB DnaN 1-methyladenine N3-methylcytosine DNA-base-CH3 a nucleobase within DNA a reduced ETF acetaldehyde ada-alkB ada-alkB_mRNA adenine aidB aidB_mRNA alkA alkA_mRNA an alkylated DNA a base(2) an oxidized ETF cytosine formol isovaleryl-CoA oxygen succinate oxygen oxygen CO2 CO2 oxygen Ada


Gensor Unit       
Name: Ada
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006307 - DNA dealkylation involved in DNA repair
GO:0080111 - DNA demethylation
GO:0006281 - DNA repair
GO:0042245 - RNA repair
GO:0006284 - base-excision repair
GO:0006285 - base-excision repair, AP site formation
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cellular_component GO:0005737 - cytoplasm
GO:0032993 - protein-DNA complex
molecular_function GO:0103053 - 1-ethyladenine demethylase activity
GO:0003677 - DNA binding
GO:0008725 - DNA-3-methyladenine glycosylase activity
GO:0043916 - DNA-7-methylguanine glycosylase activity
GO:0043734 - DNA-N1-methyladenine dioxygenase activity
GO:0032131 - alkylated DNA binding
GO:0003905 - alkylbase DNA N-glycosylase activity
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Components: Show/Hide Components Table (36 more...)
Function Name Type
simple_molecule 1-ethyladenine simple_molecule
simple_molecule 1-methyladenine simple_molecule
simple_molecule 3-methylcrotonyl-CoA simple_molecule
protein Ada protein
complex Ada-methyl complex
protein AidB protein
protein AlkA protein
protein AlkB protein
simple_molecule CO2 simple_molecule
simple_molecule DNA 6-O-methylguanine simple_molecule
simple_molecule DNA guanine simple_molecule
simple_molecule DNA(N) simple_molecule
simple_molecule DNA-base-CH3 simple_molecule
simple_molecule N3-methylcytosine simple_molecule
simple_molecule [protein]-S-methyl-L-cysteine simple_molecule
gene ada-alkB gene
RNA ada-alkB_mRNA RNA
simple_molecule adenine simple_molecule
gene aidB gene
RNA aidB_mRNA RNA
gene alkA gene
RNA alkA_mRNA RNA
simple_molecule alkylated DNA simple_molecule
simple_molecule base(2) simple_molecule
simple_molecule cytosine simple_molecule
simple_molecule ethanal simple_molecule
simple_molecule formol simple_molecule
simple_molecule isovaleryl-CoA simple_molecule
simple_molecule ketoglutarate simple_molecule
simple_molecule methyl simple_molecule
simple_molecule nucleobase within DNA simple_molecule
simple_molecule oxidized ETF simple_molecule
simple_molecule oxygen simple_molecule
simple_molecule peptide cysteine simple_molecule
simple_molecule reduced ETF simple_molecule
simple_molecule succinate simple_molecule


Reactions       
Showing 15 reactions
Ada Ada-methyl aidB aidB_mRNA
Name: aidB -> aidB_mRNA
Description: Transcription of transcription unit aidB. Reaction activation by Ada, and Ada-methyl.
Type: transcription
Pathway Components: aidB - Ada - Ada-methyl -> aidB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator Ada protein nd nd
activator Ada-methyl complex nd nd
reactant aidB gene nd nd
product aidB_mRNA RNA nd nd
Ada Ada-methyl alkA alkA_mRNA
Name: alkA -> alkA_mRNA
Description: Transcription of transcription unit alkA. Reaction activation by Ada, and Ada-methyl.
Type: transcription
Pathway Components: alkA - Ada - Ada-methyl -> alkA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator Ada protein nd nd
activator Ada-methyl complex nd nd
reactant alkA gene nd nd
product alkA_mRNA RNA nd nd
Ada Ada Ada-methyl Ada-methyl ada-alkB ada-alkB_mRNA
Name: ada-alkB -> ada-alkB_mRNA
Description: Transcription of transcription unit ada-alkB. Reaction activation by Ada, and Ada-methyl. Reaction inhibition by Ada, and Ada-methyl.
Type: transcription
Pathway Components: ada-alkB - Ada - Ada-methyl - Ada - Ada-methyl -> ada-alkB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator Ada protein nd nd
inhibitor Ada protein nd nd
activator Ada-methyl complex nd nd
inhibitor Ada-methyl complex nd nd
reactant ada-alkB gene nd nd
product ada-alkB_mRNA RNA nd nd
methyl + Ada Ada-methyl
Name: methyl + Ada -> Ada-methyl
Description: Reaction transforming methyl, Ada into Ada-methyl
Type: state transition
Pathway Components: methyl + Ada -> Ada-methyl
Components:
Function Name Type Evidence Reference(s)
reactant Ada protein nd nd
product Ada-methyl complex nd nd
reactant methyl simple_molecule nd nd
aidB_mRNA AidB
Name: aidB_mRNA -> AidB
Description: Translation of AidB
Type: translation
Pathway Components: aidB_mRNA -> AidB
Components:
Function Name Type Evidence Reference(s)
product AidB protein nd nd
reactant aidB_mRNA RNA nd nd
AidB isovaleryl-CoA + oxidized ETF 3-methylcrotonyl-CoA + reduced ETF
Name: isovaleryl-CoA + oxidized ETF -> 3-methylcrotonyl-CoA + reduced ETF
Description: Reaction transforming isovaleryl-CoA, oxidized ETF into 3-methylcrotonyl-CoA, reduced ETF
Type: state transition
Pathway Components: isovaleryl-CoA + oxidized ETF - AidB -> 3-methylcrotonyl-CoA + reduced ETF
Components:
Function Name Type Evidence Reference(s)
product 3-methylcrotonyl-CoA simple_molecule nd nd
catalyzer AidB protein nd nd
reactant isovaleryl-CoA simple_molecule nd nd
reactant oxidized ETF simple_molecule nd nd
product reduced ETF simple_molecule nd nd
ada-alkB_mRNA Ada
Name: ada-alkB_mRNA -> Ada
Description: Translation of Ada
Type: translation
Pathway Components: ada-alkB_mRNA -> Ada
Components:
Function Name Type Evidence Reference(s)
product Ada protein nd nd
reactant ada-alkB_mRNA RNA nd nd
Ada DNA 6-O-methylguanine + peptide cysteine [protein]-S-methyl-L-cysteine + DNA guanine
Name: DNA 6-O-methylguanine + peptide cysteine -> [protein]-S-methyl-L-cysteine + DNA guanine
Description: Reaction transforming DNA 6-O-methylguanine, peptide cysteine into [protein]-S-methyl-L-cysteine, DNA guanine
Type: state transition
Pathway Components: DNA 6-O-methylguanine + peptide cysteine - Ada -> [protein]-S-methyl-L-cysteine + DNA guanine
Components:
Function Name Type Evidence Reference(s)
catalyzer Ada protein nd nd
reactant DNA 6-O-methylguanine simple_molecule nd nd
product DNA guanine simple_molecule nd nd
product [protein]-S-methyl-L-cysteine simple_molecule nd nd
reactant peptide cysteine simple_molecule nd nd
ada-alkB_mRNA AlkB
Name: ada-alkB_mRNA -> AlkB
Description: Translation of AlkB
Type: translation
Pathway Components: ada-alkB_mRNA -> AlkB
Components:
Function Name Type Evidence Reference(s)
product AlkB protein nd nd
reactant ada-alkB_mRNA RNA nd nd
AlkB ketoglutarate + DNA-base-CH3 + oxygen nucleobase within DNA + succinate + formol + CO2
Name: ketoglutarate + DNA-base-CH3 + oxygen -> nucleobase within DNA + succinate + formol + CO2
Description: Reaction transforming ketoglutarate, DNA-base-CH3, oxygen into nucleobase within DNA, succinate , formol , CO2
Type: state transition
Pathway Components: ketoglutarate + DNA-base-CH3 + oxygen - AlkB -> nucleobase within DNA + succinate + formol + CO2
Components:
Function Name Type Evidence Reference(s)
catalyzer AlkB protein nd nd
product CO2 simple_molecule nd nd
reactant DNA-base-CH3 simple_molecule nd nd
product formol simple_molecule nd nd
reactant ketoglutarate simple_molecule nd nd
product nucleobase within DNA simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product succinate simple_molecule nd nd
AlkB 1-ethyladenine + ketoglutarate + oxygen succinate + adenine + ethanal + CO2
Name: 1-ethyladenine + ketoglutarate + oxygen -> succinate + adenine + ethanal + CO2
Description: Reaction transforming 1-ethyladenine, ketoglutarate, oxygen into succinate, adenine , ethanal , CO2
Type: state transition
Pathway Components: 1-ethyladenine + ketoglutarate + oxygen - AlkB -> succinate + adenine + ethanal + CO2
Components:
Function Name Type Evidence Reference(s)
reactant 1-ethyladenine simple_molecule nd nd
catalyzer AlkB protein nd nd
product CO2 simple_molecule nd nd
product adenine simple_molecule nd nd
product ethanal simple_molecule nd nd
reactant ketoglutarate simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product succinate simple_molecule nd nd
AlkB N3-methylcytosine + ketoglutarate + oxygen succinate + cytosine + formol + CO2
Name: N3-methylcytosine + ketoglutarate + oxygen -> succinate + cytosine + formol + CO2
Description: Reaction transforming N3-methylcytosine, ketoglutarate, oxygen into succinate, cytosine , formol , CO2
Type: state transition
Pathway Components: N3-methylcytosine + ketoglutarate + oxygen - AlkB -> succinate + cytosine + formol + CO2
Components:
Function Name Type Evidence Reference(s)
catalyzer AlkB protein nd nd
product CO2 simple_molecule nd nd
reactant N3-methylcytosine simple_molecule nd nd
product cytosine simple_molecule nd nd
product formol simple_molecule nd nd
reactant ketoglutarate simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product succinate simple_molecule nd nd
AlkB 1-methyladenine + ketoglutarate + oxygen succinate + adenine + formol + CO2
Name: 1-methyladenine + ketoglutarate + oxygen -> succinate + adenine + formol + CO2
Description: Reaction transforming 1-methyladenine, ketoglutarate, oxygen into succinate, adenine , formol , CO2
Type: state transition
Pathway Components: 1-methyladenine + ketoglutarate + oxygen - AlkB -> succinate + adenine + formol + CO2
Components:
Function Name Type Evidence Reference(s)
reactant 1-methyladenine simple_molecule nd nd
catalyzer AlkB protein nd nd
product CO2 simple_molecule nd nd
product adenine simple_molecule nd nd
product formol simple_molecule nd nd
reactant ketoglutarate simple_molecule nd nd
reactant oxygen simple_molecule nd nd
product succinate simple_molecule nd nd
alkA_mRNA AlkA
Name: alkA_mRNA -> AlkA
Description: Translation of AlkA
Type: translation
Pathway Components: alkA_mRNA -> AlkA
Components:
Function Name Type Evidence Reference(s)
product AlkA protein nd nd
reactant alkA_mRNA RNA nd nd
AlkA alkylated DNA base(2) + DNA(N)
Name: alkylated DNA -> base(2) + DNA(N)
Description: Reaction transforming alkylated DNA into base(2), DNA(N)
Type: state transition
Pathway Components: alkylated DNA - AlkA -> base(2) + DNA(N)
Components:
Function Name Type Evidence Reference(s)
catalyzer AlkA protein nd nd
product DNA(N) simple_molecule nd nd
reactant alkylated DNA simple_molecule nd nd
product base(2) simple_molecule nd nd



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