Name: |
lrp |
Synonym(s): |
OP00251 |
Gene(s): |
lrp
Genome Browser
M3D Gene expression
COLOMBOS
|
Note(s): |
It is not yet clear whether there are other genes dowstream of lrp that are transcribed from the lrpp promoter. ftsK is a gene regulated by LexA, and the ts gene immediately dowstream of lrp is transcribed in the same direction. It is likely that ftsK has a separate promoter, because the expression of ftsK is markedly increased after treatment of E. coli with mitomycin. BglG has a regulatory role in lrp expression through two independent mechanisms, one being the gcvA-gcvB pathway and the other through GadE during stationary phase. BglB also has a physiological role in elimination of toxic metabolites generated by the catabolism of serine-containing peptides; these peptides are the result of elevated levels of uptake Shukla S,2019 |
Reference(s): |
[1] Wang Q., et al., 1994
|
Promoter |
|
Name: |
lrpp |
+1: |
932328 |
Sigma Factor: |
Sigma70 Sigmulon |
Distance from start of the gene: |
267
|
Sequence: |
ttgtactaaaaatcgatgttttgctttgacaatcccctggtgttttgcgaaaacattcgaGgaagaaaaaaaacagtattc -35 -10 +1
|
Evidence: |
[ICWHO] [TIM]
|
Reference(s): |
[2] Huerta AM., et al., 2003 [1] Wang Q., et al., 1994
|
Transcription factor |
Function |
Promoter |
Binding Sites |
Evidence (Confirmed, Strong, Weak) |
Reference(s) |
LeftPos |
RightPos |
Central Rel-Pos |
Sequence |
Lrp |
repressor |
lrpp |
932265
|
932279
|
-56.0
|
aatatctggcATGTTGTACTAAAAAtcgatgtttt
|
nd
|
[1]
|
Lrp |
repressor |
lrpp |
932328
|
932343
|
8.0
|
aaacattcgaGGAAGAAAAAAAACAGtattcttata
|
[GEA]
|
[6]
|
Lrp |
repressor |
lrpp |
932351
|
932368
|
32.0
|
cagtattcttATATGCGCATAACCATGCatgtaaatac
|
[GEA]
|
[6]
|
Lrp |
repressor |
lrpp |
932369
|
932383
|
49.0
|
ataaccatgcATGTAAATACCATGTttaccgtgct
|
nd
|
[1], [7], [8]
|
NsrR |
repressor |
lrpp |
932374
|
932385
|
52.0
|
catgcatgtaAATACCATGTTTaccgtgctag
|
[GEA]
|
[9]
|
GadE |
activator |
lrpp |
nd
|
nd
|
nd
|
nd
|
[GEA]
|
[10]
|
H-NS |
repressor |
lrpp |
nd
|
nd
|
nd
|
nd
|
[GEA]
|
[11]
|
sRNA |
TU Regulated |
Function |
Binding Sites |
Regulatory Mechanism |
Evidence (Confirmed, Strong, Weak) |
Reference(s) |
PosLeft |
PosRight |
Target sequence (mRNA) |
small regulatory RNA MicF
|
lrp
|
repressor
|
932573
|
932606
|
GGAAUACAGAGAGACAAUAAUAAUGGUAGAUAGC
|
TRANSLATION-BLOCKING
|
[IEP], [SM]
|
[3], [4]
|
small regulatory RNA GcvB
|
lrp
|
repressor
|
932556
|
932563
|
CAGACAGG
|
nd
|
[IEP], [IPI], [SM]
|
[4], [5]
|
small regulatory RNA DsrA
|
lrp
|
repressor
|
932598
|
932615
|
GUAGAUAGCAAGAAGCGC
|
nd
|
[IEP], [SM]
|
[4]
|
small regulatory RNA GcvB
|
lrp
|
repressor
|
932416
|
932420
|
GACAG
|
nd
|
[IEP], [IPI], [SM]
|
[4]
|