RegulonDB RegulonDB 10.9: Operon Form
   

mngR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: mngR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: mngR
Gene(s): mngR   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Quail MA., et al., 1994
Promoter
Name: mngRp
+1: 765926
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 51
Sequence: cattatgtgatcaatttcacttgattgaaattatttgtattgtatttgtattatttacagGatgaatttatcgggcataat
                         -35                     -10        +1                   
Evidence: [HIPP]
[ICWHO]
Reference(s): [2] Buck D., et al., 1989
[3] Huerta AM., et al., 2003
[1] Quail MA., et al., 1994
Terminator(s)
Type: rho-independent
Sequence: atggcgaaggGCTGTCGGTTTCGACATGGTTGGCCATCGTATGATGGCCTTTTTTGTGCTTATCGcgatgatttt
Reference(s): [4] Feng CQ., et al., 2019
[5] Lesnik EA., et al., 2001
TF binding sites (TFBSs)
[MngR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MngR repressor mngRp 765890 765911 26.5 aatttatcggGCATAATGGTTAAATTCGTATTAatgagatact nd [APIORCISFBSCS], [BPP] [6]
proximal MngR repressor mngRp 765934 765955 -18.5 ttgattgaaaTTATTTGTATTGTATTTGTATTAtttacaggat nd [APIORCISFBSCS], [BPP], [GEA] [6]


Evidence    

 [HIPP] Human inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis


Reference(s)    

 [1] Quail MA., Dempsey CE., Guest JR., 1994, Identification of a fatty acyl responsive regulator (FarR) in Escherichia coli., FEBS Lett 356(2-3):183-7

 [2] Buck D., Guest JR., 1989, Overexpression and site-directed mutagenesis of the succinyl-CoA synthetase of Escherichia coli and nucleotide sequence of a gene (g30) that is adjacent to the suc operon., Biochem J 260(3):737-47

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Feng CQ., Zhang ZY., Zhu XJ., Lin Y., Chen W., Tang H., Lin H., 2019, iTerm-PseKNC: a sequence-based tool for predicting bacterial transcriptional terminators., Bioinformatics 35(9):1469-1477

 [5] Lesnik EA., Sampath R., Levene HB., Henderson TJ., McNeil JA., Ecker DJ., 2001, Prediction of rho-independent transcriptional terminators in Escherichia coli., Nucleic Acids Res 29(17):3583-94

 [6] Sampaio MM., Chevance F., Dippel R., Eppler T., Schlegel A., Boos W., Lu YJ., Rock CO., 2004, Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor., J Biol Chem 279(7):5537-48

RegulonDB