RegulonDB RegulonDB 10.10: Operon Form
   

dsdC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: dsdC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: dsdC
Synonym(s): OP00200
Gene(s): dsdC   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Bornstein-Forst SM., et al., 1987
[2] Carothers AM., et al., 1980
[3] Norregaard-Madsen M., et al., 1995
Promoter
Name: dsdCp
+1: 2477746
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 117
Sequence: aaaaaacaacgcaggctgacaaacgataaaatttgcctttcacatgaggtaaattgcatcAatggagtgatttacatctaa
                          -35                     -10       +1                   
Evidence: [AIPP]
[ICWHO]
Reference(s): [4] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[DsdC,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd DsdC-D-serine repressor dsdCp nd nd nd nd nd [GEA], [BPP] [6]
[NsrR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal NsrR repressor dsdCp 2477728 2477739 14.0 atcaatggagTGATTTACATCTaaaaatgaag nd [GEA], [APIORCISFBSCS] [5]


Evidence    

 [AIPP] Automated inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [GEA] Gene expression analysis

 [BPP] Binding of purified proteins

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.


Reference(s)    

 [1] Bornstein-Forst SM., McFall E., Palchaudhuri S., 1987, In vivo D-serine deaminase transcription start sites in wild-type Escherichia coli and in dsdA promoter mutants., J Bacteriol 169(3):1056-60

 [2] Carothers AM., McFall E., Palchaudhuri S., 1980, Physical mapping of the Escherichia coli D-serine deaminase region: contiguity of the dsd structural and regulatory genes., J Bacteriol 142(1):174-84

 [3] Norregaard-Madsen M., McFall E., Valentin-Hansen P., 1995, Organization and transcriptional regulation of the Escherichia coli K-12 D-serine tolerance locus., J Bacteriol 177(22):6456-61

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [5] Partridge JD., Bodenmiller DM., Humphrys MS., Spiro S., 2009, NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility., Mol Microbiol 73(4):680-94

 [6] McFall E., Heincz MC., 1983, Identification and control of synthesis of the dsdC activator protein., J Bacteriol 153(2):872-7

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