RegulonDB RegulonDB 10.6.3: Operon Form
   

fabB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: fabB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: fabB
Gene(s): fabB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Kauppinen S., et al., 1988
Promoter
Name: fabBp
+1: 2441641
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 36
Sequence: ttctctattaaatggctgatcggacttgttcggcgtacaagtgtacgctattgtgcattcGaaacttactctatgtgcgac
                          -10                    -35        +1                   
Evidence: [RS-EPT-CBR]
[TIM] ; Method: Primer Extension
[TIM]
Reference(s): [1] Kauppinen S., et al., 1988
[2] Salgado H, et al., 2012
Terminator(s)
Type: rho-independent
Sequence: caatgatgtgAAAAAGGGAACCATCAGGTTCCCTTTTGcgttagtgcc
Reference(s): [1] Kauppinen S., et al., 1988
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FabR repressor fabBp 2441653 2441670 -20.5 ggacttgttcGGCGTACAAGTGTACGCTattgtgcatt nd [BCE], [BPP], [GEA], [HIBSCS] [5], [6], [7]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FadR activator fabBp 2441672 2441688 -39.0 tctattaaatGGCTGATCGGACTTGTTcggcgtacaa nd [BPP], [GEA], [HIBSCS] [3], [4], [5]




Reference(s)    

 [1] Kauppinen S., Siggaard-Andersen M., von Wettstein-Knowles P., 1988, beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue., Carlsberg Res Commun 53(6):357-70

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Campbell JW., Cronan JE., 2001, Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene., J Bacteriol 183(20):5982-90

 [4] DiRusso CC., Black PN., Weimar JD., 1999, Molecular inroads into the regulation and metabolism of fatty acids, lessons from bacteria., Prog Lipid Res 38(2):129-97

 [5] Feng Y., Cronan JE., 2011, Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters., Mol Microbiol 80(1):195-218

 [6] McCue L., Thompson W., Carmack C., Ryan MP., Liu JS., Derbyshire V., Lawrence CE., 2001, Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes., Nucleic Acids Res 29(3):774-82

 [7] Zhang YM., Marrakchi H., Rock CO., 2002, The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli., J Biol Chem 277(18):15558-65


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