RegulonDB RegulonDB 10.8: Operon Form
   

narU operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: narU
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: narU
Gene(s): narU   Genome Browser M3D Gene expression COLOMBOS
Note(s): Activation of the narUZYWV cluster, which is poorly conserved even in Escherichia, represents a novel strategy to significantly improve osmotic stress tolerance. Precise control of the composition of OmpR-regulated membrane proteins is crucial for E. coli K-12 MG1655 viability Seo SW, Gao Y, Kim D, Szubin R, Yang J, Cho BK, Palsson BO,2017.
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: narUp1
+1: 1544124
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 64
Sequence: tttcttatctattctttcaatcagcacttcacccaattcatccttaattctaataactggCtattgcgccttacctcgtgt
                    -35                       -10           +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
Reference(s): [1] Chang L., et al., 1999


Transcription unit       
Name: narU
Gene(s): narU   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: narUp2
+1: 1544163
Sigma Factor: Sigma38 Sigmulon
Distance from start of the gene: 103
Sequence: tctggctacttaatccccattctgcccccgcggttacgctttcttatctattctttcaatCagcacttcacccaattcatc
                           -35              -10             +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
Reference(s): [1] Chang L., et al., 1999


Evidence    

 [HIPP] Human inference of promoter position


Reference(s)    

 [1] Chang L., Wei LI., Audia JP., Morton RA., Schellhorn HE., 1999, Expression of the Escherichia coli NRZ nitrate reductase is highly growth phase dependent and is controlled by RpoS, the alternative vegetative sigma factor., Mol Microbiol 34(4):756-66

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