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Name: | hmp | |||||||||
Gene(s): | hmp Genome Browser M3D Gene expression COLOMBOS | |||||||||
Note(s): | Membrillo et al. in 1998 showed that MetR at low concentrations activates the hmp gene, when it binds to the binding site located at -80 Membrillo-Hernandez J,1998, and simultaneously represses transcription of the glyA gene Membrillo-Hernandez J,1998. In addition, they showed that homocysteine did not alter the levels of transcription of this gene and that S-nitrosoglutathione and sodium nitroprusside increase transcription of the hmp gene in the presence of MetR. Based on gene expression analysis, it was shown that CsgD could be a negative regulator of hmp expression Herrington MB,2013 |
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Evidence: | [AISGDTU] Automated inference that a single-gene directon is a transcription unit [BTEI] Boundaries of transcription experimentally identified |
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Reference(s): |
[1] Membrillo-Hernandez J., et al., 1997 [2] Plamann MD., et al., 1983 |
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Promoter | ||||||||||
Name: | hmpp | |||||||||
+1: | 2685797 | |||||||||
Sigma Factor: | Sigma38 Sigmulon | |||||||||
Distance from start of the gene: | 38 | |||||||||
Sequence: |
tttctgaaaaacaccaaagaaccatttacattgcagggctattttttataagatgcatttGagatacatcaattaagatgc -35 -10 +1 |
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Note(s): | Hydrogen peroxide (H2O2) and nitric oxide (NO) stresses suppress the transcript output of the hmpp promoter, even in the absence of NsrR; however, prioritized detoxification depends on both NsrR and Hmp Adolfsen KJ, Chou WK, Brynildsen MP,2019 | |||||||||
Evidence: |
[APIORCISFBSCS] [CV(RPF/TIM)] [HIPP] [ICWHO] [RPF] [TIM] |
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Reference(s): |
[3] Huerta AM., et al., 2003 [1] Membrillo-Hernandez J., et al., 1997 [2] Plamann MD., et al., 1983 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | FNR | repressor | hmpp | 2685795 | 2685808 | 5.5 | taagatgcatTTGAGATACATCAAttaagatgca | nd | [GEA], [APIORCISFBSCS], [BPP], [SM] | [1], [10], [11] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | Fur-Fe2+ | repressor | hmpp | 2685793 | 2685811 | 6.0 | tataagatgcATTTGAGATACATCAATTAagatgcaaaa | nd | [AS], [GEA], [IMP], [APIORCISFBSCS], [AS] | [12], [13], [14] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | MetR | activator | hmpp | 2685710 | 2685724 | -80.0 | caggtttgtgATGCAAATTTTTCACttcatcacat | nd | [GEA], [IMP], [APIORCISFBSCS], [BPP], [SM] | [5], [6], [7] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | NsrR | repressor | hmpp | 2685754 | 2685765 | -38.0 | aaaacaccaaAGAACCATTTACattgcagggc | nd | [GEA], [APIORCISFBSCS] | [8] |
proximal | NsrR | repressor | hmpp | 2685789 | 2685807 | 2.0 | tttttataagATGCATTTGAGATACATCAattaagatgc | nd | [GEA], [AIBSCS] | [9] |
proximal | NsrR | repressor | hmpp | 2685811 | 2685822 | 20.0 | tacatcaattAAGATGCAAAAAaaggaagacc | nd | [GEA], [APIORCISFBSCS] | [8] |
Evidence: | [GEA] Gene expression analysis |
Reference(s): | [1] Membrillo-Hernandez J., et al., 1997 |
Reference(s) |
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