RegulonDB RegulonDB 10.7: Operon Form

grxA operon and associated TUs in Escherichia coli K-12 genome

Name: grxA
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: grxA
Gene(s): grxA   Genome Browser M3D Gene expression COLOMBOS
Note(s): The transcription of the gene grxA is enhanced under high oxygen saturation (300%) in the absence of the superoxide dismutase proteins SodA and SodB |CITS:[ 23497217]|.
Sulfane sulfur modifies OxyR at Cys199 to form a protein persulfide that in turn activates the expression of grxA, trxC, and katG promoters under both aerobic and anaerobic conditions |CITS:[31421411]|.
Reference(s): [1] Tao K. 1997
Name: grxAp
+1: 890776
Distance from start of the gene: 23
Sequence: attaatgcaacaggttaaacctactttcagcgaatacattttagcgtgatcattacaggcAtaaatctatgaggagagaaa
Evidence: [TIM] ; Method: Primer Extension
Reference(s): [1] Tao K. 1997
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal OxyR activator grxAp 890761 890777 8.0 tcattacaggCATAAATCTATGAGGAGagaaataatg nd , [IHBCE], [2]
proximal OxyR activator grxAp 890812 890828 -44.0 caattaatgcAACAGGTTAAACCTACTttcagcgaat nd [APIORCISFBSCS], [BPP], [GEA] [1], [3]
proximal OxyR activator grxAp 890834 890850 -66.0 gtttaacagtTATAGCTTTTAGCAATTaatgcaacag nd [APIORCISFBSCS], [BPP], , [GEA], [IHBCE], [1], [2], [3]