RegulonDB RegulonDB 10.8: Operon Form
   

fixABCX operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: fixABCX
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: fixABCX
Gene(s): fixA, fixB, fixC, fixX   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Eichler K., et al., 1995
Promoter
Name: fixAp
+1: 42325
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 78
Sequence: tattgaaagttggatttatctgcgtgtgacattttcaatattggtgattaaagttttattTcaaaattaaagggcgtgata
                          -35                    -10        +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [2] Eichler K., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote CRP-cAMP1 activator fixAp 42188 42209 -126.5 gactttcaatATTGGTGATCCATAAAACAATAttgaaaattt nd [APIORCISFBSCS], [CV(GEA)], [GEA] [2], [5], [6]
proximal CRP-cAMP2 activator fixAp 42245 42266 -69.5 tgttttcaatATTGGTGAGGAACTTAACAATAttgaaagttg nd [APIORCISFBSCS], [CV(GEA)], [GEA] [2], [5], [6]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote CaiF-L-carnitine activator fixAp 42181 42196 -136.5 aacatctgacTTTCAATATTGGTGATccataaaaca nd [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [5]
remote CaiF-L-carnitine2 activator fixAp 42200 42215 -117.5 tggtgatccaTAAAACAATATTGAAAatttcttttt nd [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [5]
proximal CaiF-L-carnitine activator fixAp 42238 42253 -79.5 tacgccgtgtTTTCAATATTGGTGAGgaacttaaca nd [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [5]
proximal CaiF-L-carnitine4 activator fixAp 42257 42272 -60.5 tggtgaggaaCTTAACAATATTGAAAgttggattta nd [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote FNR activator fixAp 42121 42134 -197.5 cgttttttcgTTAATTTTGATTAAtaatcagttt nd [AIBSCS], [CV(GEA)], [GEA] [3], [4]
Note(s): 1CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.
2CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.2CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.
4CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.3CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.
4CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.
6CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.
7CaiF and CRP bind cooperatively to the cai-fix intergenic region to activate the fixA promoter.


RNA cis-regulatory element    
Regulation, transcriptional elongation  
Attenuator type: Translational
Strand: forward
  Structure type Energy LeftPos RightPos Sequence (RNA-strand)
  terminator -19.2 44134 44174 gttgatccacTCTGGCAGGGCTGCATTTTGGCCCTGCCGCTGACAGGGAGctcttatgtc
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos"





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