RegulonDB RegulonDB 10.8: Operon Form
   

nmpC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: nmpC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: nmpC
Synonym(s): lc, phmA, phmA/nmpC
Gene(s): nmpC   Genome Browser M3D Gene expression COLOMBOS
Note(s): Based on microarray and RT-qPCR analyses, it was determined that the yebF and nmpC genes are up- and downregulated, respectively, upon exposure to glutathione (GSH) Goswami M,2018
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Blasband AJ., et al., 1986
[2] Coll JL., et al., 1994
Promoter
Name: nmpCp
+1: 576870
Distance from start of the gene:
Sequence:
Evidence: [HIPP]
[TIM]
Reference(s): [1] Blasband AJ., et al., 1986
[2] Coll JL., et al., 1994
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator nmpCp 576891 576912 -31.5 accaaaacttACATCTTGAAATAATCACATTGattagatgaa nd [APIORCISFBSCS], [SM] [2]
proximal CRP-cAMP activator nmpCp 576933 576954 -73.5 ttcagataaaAATAGAGATCTACTTCACAAATcaaacgagaa nd [APIORCISFBSCS], [SM] [2]
[IHF,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote IHF repressor nmpCp 577008 577020 -144.0 ataaattggcTAATAGATTTATTtttattcagc nd [APIORCISFBSCS], [SM] [2]
[MprA,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote MprA repressor nmpCp 577021 577041 -161.0 ttataaataaCAGCCGTTAATATAAATTGGCtaatagattt nd [AIBSCS] [3]
[OmpR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal OmpR-P repressor nmpCp 576906 576925 -45.5 aatcaaacgaGAAACCAAAACTTACATCTTgaaataatca nd [APIORCISFBSCS], [SM] [2]


Evidence    

 [HIPP] Human inference of promoter position

 [TIM] Transcription initiation mapping

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [SM] Site mutation

 [AIBSCS] Automated inference based on similarity to consensus sequences


Reference(s)    

 [1] Blasband AJ., Marcotte WR., Schnaitman CA., 1986, Structure of the lc and nmpC outer membrane porin protein genes of lambdoid bacteriophage., J Biol Chem 261(27):12723-32

 [2] Coll JL., Heyde M., Portalier R., 1994, Expression of the nmpC gene of Escherichia coli K-12 is modulated by external pH. Identification of cis-acting regulatory sequences involved in this regulation., Mol Microbiol 12(1):83-93

 [3] Rodionov DA., Gelfand MS., Mironov AA., Rakhmaninova AB., 2001, Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria., J Mol Microbiol Biotechnol 3(2):319-24

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