RegulonDB RegulonDB 10.9: Operon Form
   

rpoZ-spoT-trmH-recG operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: rpoZ-spoT-trmH-recG
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: rpoZ-spoT-trmH-recG
Synonym(s): rpoZ-spoTU-recG
Gene(s): rpoZ, spoT, trmH, recG   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Kalman M., et al., 1992
Promoter
Name: rpoZp
+1: 3822077
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 29
Sequence: atgacgctttaatcagcaaattgttggcagactgaacctgatttcagtatcatgcccagtCatttcttcacctgtggagct
                        -35                     -10         +1                   
Evidence: [ICWHO]
[RS-EPT-CBR]
[TAS]
Reference(s): [2] Gentry D., et al., 1993
[3] Huerta AM., et al., 2003
[4] Salgado H, et al., 2012
Allosteric regulation of RNA-polymerase
  Regulator Function Promoter target of RNApol Growth Conditions Note Evidence Reference
  DksA-ppGpp inhibition rpoZp nd Together ppGpp and DksA can inhibit more strongly the transcription initiation from the ribosomal protein promoter in vitro and in vivo Lemke JJ,2011 [APPH]
[GEA]
[IMP]
[5]
Evidence: [APPH] Assay of protein purified to homogeneity
[GEA] Gene expression analysis
[IMP] Inferred from mutant phenotype
Reference(s): [5] Lemke JJ., et al., 2011


Transcription unit       
Name: recG
Gene(s): recG   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ITCR] Inferred through co-regulation
Reference(s): [6] Avison MB., et al., 2001




Reference(s)    

 [1] Kalman M., Murphy H., Cashel M., 1992, The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12., Gene 110(1):95-9

 [2] Gentry D., Bengra C., Ikehara K., Cashel M., 1993, Guanylate kinase of Escherichia coli K-12., J Biol Chem 268(19):14316-21

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Lemke JJ., Sanchez-Vazquez P., Burgos HL., Hedberg G., Ross W., Gourse RL., 2011, Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA., Proc Natl Acad Sci U S A 108(14):5712-7

 [6] Avison MB., Horton RE., Walsh TR., Bennett PM., 2001, Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media., J Biol Chem 276(29):26955-61


RegulonDB