RegulonDB RegulonDB 10.8: Operon Form
   

ruvAB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: ruvAB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: ruvAB
Gene(s): ruvB, ruvA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Benson FE., et al., 1988
[2] Iwasaki H., et al., 1989
[3] Shinagawa H., et al., 1988
Promoter
Name: ruvAp2
+1: 1946016
Distance from start of the gene: 40
Sequence: tcgagacacctcgcaagttttcttcatccttcgctggatatctatccagcatttttttatCatacagcattatctttgatt
Evidence: [TIM]
Reference(s): [3] Shinagawa H., et al., 1988
Terminator(s)
Type: rho-independent
Sequence: ctctggtagtCCTGGTAAGACGCGAACAGCGTCGCATCAGGcatattgcca
Reference(s): [3] Shinagawa H., et al., 1988
Type: rho-independent
Sequence: gaacacatttGTCGGATGCGGCGCGAGCGCCTTATCCGACctacggttcg
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal LexA repressor ruvAp2 1946026 1946045 -19.5 cttcatccttCGCTGGATATCTATCCAGCAtttttttatc nd [APIORCISFBSCS], [BPP] [1], [3], [4], [5]
proximal LexA repressor ruvAp2 1946079 1946098 -72.5 gaataaattaTACTGTGCCATTTTTCAGTTcatcgagaca nd [APIORCISFBSCS] [1], [4]


Transcription unit          
Name: ruvAB
Gene(s): ruvB, ruvA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Based on the bacteriostatic antibiotic-induced persister model, 37 and 9 genes were found to produce defects in rifampin- and tetracycline-induced persister formation, respectively. Only six mutants were found to overlap in both treatment-induced persister screens: recA, recC, ruvA, uvrD, fis, and acrB. Four of these mutants (recA, recC, ruvA, and uvrD) mapped to the DNA repair pathway, one mutant mapped to a global transcriptional regulator (fis), and one to a gene for an efflux protein (acrB) 29559967 Other genes that mapped to transporters, membrane biogenesis, LPS biosynthesis, flagellum biosynthesis, metabolism (folate and energy), and translation were more specific to rifampin-induced persisters 29559967
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Benson FE., et al., 1988
[2] Iwasaki H., et al., 1989
[3] Shinagawa H., et al., 1988
Promoter
Name: ruvAp1
+1: 1946024
Distance from start of the gene: 48
Sequence: tcagttcatcgagacacctcgcaagttttcttcatccttcgctggatatctatccagcatTtttttatcatacagcattat
Evidence: [TIM]
Reference(s): [3] Shinagawa H., et al., 1988
Terminator(s)
Type: rho-independent
Sequence: ctctggtagtCCTGGTAAGACGCGAACAGCGTCGCATCAGGcatattgcca
Reference(s): [3] Shinagawa H., et al., 1988
Type: rho-independent
Sequence: gaacacatttGTCGGATGCGGCGCGAGCGCCTTATCCGACctacggttcg
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal LexA repressor ruvAp1 1946027 1946046 -12.5 tcttcatcctTCGCTGGATATCTATCCAGCatttttttat nd [APIORCISFBSCS], [BPP] [1], [3], [4], [5]
proximal LexA repressor ruvAp1 1946078 1946097 -63.5 aataaattatACTGTGCCATTTTTCAGTTCatcgagacac nd [APIORCISFBSCS] [1], [4]





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