|
|
| Operon |  |
|---|---|
| Name: | ruvAB |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | ruvAB | |||||||||
| Gene(s): | ruvB, ruvA Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Evidence: | [BTEI] Boundaries of transcription experimentally identified | |||||||||
| Reference(s): |
[1] Benson FE., et al., 1988 [2] Iwasaki H., et al., 1989 [3] Shinagawa H., et al., 1988 |
|||||||||
| Promoter | ||||||||||
| Name: | ruvAp2 | |||||||||
| +1: | 1946016 | |||||||||
| Distance from start of the gene: | 40 | |||||||||
| Sequence: |
tcgagacacctcgcaagttttcttcatccttcgctggatatctatccagcatttttttatCatacagcattatctttgatt |
|||||||||
| Evidence: | [TIM] | |||||||||
| Reference(s): | [3] Shinagawa H., et al., 1988 | |||||||||
| Terminator(s) | ||||||||||
| Type: | rho-independent | |||||||||
| Sequence: | ctctggtagtCCTGGTAAGACGCGAACAGCGTCGCATCAGGcatattgcca | |||||||||
| Reference(s): | [3] Shinagawa H., et al., 1988 | |||||||||
| Type: | rho-independent | |||||||||
| Sequence: | gaacacatttGTCGGATGCGGCGCGAGCGCCTTATCCGACctacggttcg | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | LexA | repressor | ruvAp2 | 1946026 | 1946045 | -19.5 | cttcatccttCGCTGGATATCTATCCAGCAtttttttatc | nd | [APIORCISFBSCS], [BPP] | [3] |
| proximal | LexA | repressor | ruvAp2 | 1946079 | 1946098 | -72.5 | gaataaattaTACTGTGCCATTTTTCAGTTcatcgagaca | nd | [APIORCISFBSCS] | nd |
| Name: | ruvAB | |||||||||
| Gene(s): | ruvB, ruvA Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | Based on the bacteriostatic antibiotic-induced persister model, 37 and 9 genes were found to produce defects in rifampin- and tetracycline-induced persister formation, respectively. Only six mutants were found to overlap in both treatment-induced persister screens: recA, recC, ruvA, uvrD, fis, and acrB. Four of these mutants (recA, recC, ruvA, and uvrD) mapped to the DNA repair pathway, one mutant mapped to a global transcriptional regulator (fis), and one to a gene for an efflux protein (acrB) Cui P, Niu H, Shi W, Zhang S, Zhang W, Zhang Y,2018 Other genes that mapped to transporters, membrane biogenesis, LPS biosynthesis, flagellum biosynthesis, metabolism (folate and energy), and translation were more specific to rifampin-induced persisters Cui P, Niu H, Shi W, Zhang S, Zhang W, Zhang Y,2018 | |||||||||
| Evidence: | [BTEI] Boundaries of transcription experimentally identified | |||||||||
| Reference(s): |
[1] Benson FE., et al., 1988 [2] Iwasaki H., et al., 1989 [3] Shinagawa H., et al., 1988 |
|||||||||
| Promoter | ||||||||||
| Name: | ruvAp1 | |||||||||
| +1: | 1946024 | |||||||||
| Distance from start of the gene: | 48 | |||||||||
| Sequence: |
tcagttcatcgagacacctcgcaagttttcttcatccttcgctggatatctatccagcatTtttttatcatacagcattat |
|||||||||
| Evidence: | [TIM] | |||||||||
| Reference(s): | [3] Shinagawa H., et al., 1988 | |||||||||
| Terminator(s) | ||||||||||
| Type: | rho-independent | |||||||||
| Sequence: | ctctggtagtCCTGGTAAGACGCGAACAGCGTCGCATCAGGcatattgcca | |||||||||
| Reference(s): | [3] Shinagawa H., et al., 1988 | |||||||||
| Type: | rho-independent | |||||||||
| Sequence: | gaacacatttGTCGGATGCGGCGCGAGCGCCTTATCCGACctacggttcg | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | LexA | repressor | ruvAp1 | 1946027 | 1946046 | -12.5 | tcttcatcctTCGCTGGATATCTATCCAGCatttttttat | nd | [APIORCISFBSCS], [BPP] | [3] |
| proximal | LexA | repressor | ruvAp1 | 1946078 | 1946097 | -63.5 | aataaattatACTGTGCCATTTTTCAGTTCatcgagacac | nd | [APIORCISFBSCS] | nd |
| Reference(s) |
|
|---|---|
[TIM] Transcription initiation mapping