RegulonDB RegulonDB 10.6.3: Operon Form
   

stpA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: stpA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: stpA
Gene(s): stpA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Repression of the stpA gene by H-NS is significantly more effective when a downstream sequence encompassing the stpA coding region is present. It is possible that StpA acts on a transcriptional level or that the RNA chaperone StpA binds to its mRNA |CITS: [18245262]|.
Lrp may partly act to overcome the negative effect of HNS. Lrp activates the transcription of stpA in minimal medium; in rich medium the lower level and more transient expression of stpA is independent of Lrp.
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Free A., et al., 1997
[2] Sonden B., et al., 1996
Promoter
Name: stpAp1
+1: 2798536
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 41
Sequence: gactgtaaatagattaaattttgtggaaatataataagtgatcgcttacactacgcgacgAaatactttttttgttttggc
                     -10                       -35          +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [1] Free A., et al., 1997
[2] Sonden B., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd H-NS repressor stpAp1 nd nd nd nd nd [BCE], [BPP], [GEA] [1], [2]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote Lrp activator stpAp1 2798636 2798650 -107.0 aatatataatCTTGAAATTATTCTGagagtttcag nd [BCE], [BPP], [GEA], [HIBSCS] [1], [2]
remote Lrp activator stpAp1 2799019 2799034 -490.0 aaatttttatTTAGTCAGTTTTTGTAgataaaatat nd [BCE], [BPP], [GEA], [HIBSCS] [1], [2], [3]
remote Lrp activator stpAp1 2799068 2799083 -539.0 gcattttcgcATAGCGTATATCGCTGgctatgacta nd [BCE], [BPP], [GEA], [HIBSCS] [1], [2], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd StpA repressor stpAp1 nd nd nd nd nd [GEA] [4]


Transcription unit       
Name: stpA
Gene(s): stpA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Free A., et al., 1997
[2] Sonden B., et al., 1996
Promoter
Name: stpAp2
+1: 2798556
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 61
Sequence: gctgaaataatctcgcgcaggactgtaaatagattaaattttgtggaaatataataagtgAtcgcttacactacgcgacga
                                                  -35       +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [1] Free A., et al., 1997
[2] Sonden B., et al., 1996


Transcription unit       
Name: stpA
Gene(s): stpA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Free A., et al., 1997
[2] Sonden B., et al., 1996
Promoter
Name: stpAp3
+1: 2798578
Distance from start of the gene: 83
Sequence: ctgagagtttcagaaaataacagctgaaataatctcgcgcaggactgtaaatagattaaaTtttgtggaaatataataagt
Evidence: [TIM]
Reference(s): [2] Sonden B., et al., 1996





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