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| Operon |  |
|---|---|
| Name: | gltA |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | gltA |
| Gene(s): | gltA Genome Browser M3D Gene expression COLOMBOS |
| Note(s): | No readthrough transcription into a distal gene(s) was detected. The expression of the gene gltA is decreased under acidic growth conditions in microaerobiosis but not in aerobiosis Marzan LW,2013 The gltA gene is downregulated by long-term (8 to 12 h) exposure of E. coli to some biocides Merchel Piovesan Pereira B, Wang X, Tagkopoulos I,2020. |
| Evidence: | [LTED] Length of transcript experimentally determined |
| Reference(s): |
[1] Cunningham L., et al., 1998 [2] Wilde RJ., et al., 1986 |
| Promoter | |
| Name: | gltAp2 |
| +1: | 754670 |
| Distance from start of the gene: | 202 |
| Sequence: |
agtgtggaagtattgaccaattcattcgggacagttattagtggtagacaagtttaataaTtcggattgctaagtacttga |
| Evidence: |
[HIPP] [TIM] |
| Reference(s): |
[3] Lynch AS., et al., 1996 [4] Wood D., et al., 1984 |
| Terminator(s) | |
| Type: | rho-independent |
| Sequence: | ttaggcatatAAAAATCAACCCGCCATATGAACGGCGGGTTAAAATATttacaactta |
| Reference(s): | [5] Bhayana V., et al., 1984 |
| Name: | gltA | |||||||||
| Synonym(s): | OP00147 | |||||||||
| Gene(s): | gltA Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | No readthrough transcription into a distal gene(s) was detected. Under nitrogen-rich growth conditions, the expression of the gltA gene increased in mutants for two transcriptional regulators, Fnr and Fur. However, under nitrogen-limited growth conditions, gene expression was decreased. It is unknown if the effects of the transcriptional regulators act directly on gene expression; also, it is unknown which of the two promoters that transcribe the gene could be regulated by the regulators Kumar R,2011 The expression of the gene gltA is decreased under acidic growth conditions in microaerobiosis but not in aerobiosis Marzan LW,2013 gltA transcription is represed in the presence of glucose, suggesting that gltA can forgo complete carbon oxidation under nutrient-rich conditions Zheng D,2004. Walsh K, Koshland DE,1985 The gltA gene is downregulated by long-term (8 to 12 h) exposure of E. coli to some biocides Merchel Piovesan Pereira B, Wang X, Tagkopoulos I,2020. |
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| Evidence: | [LTED] Length of transcript experimentally determined | |||||||||
| Reference(s): |
[1] Cunningham L., et al., 1998 [2] Wilde RJ., et al., 1986 |
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| Promoter | ||||||||||
| Name: | gltAp1 | |||||||||
| +1: | 754767 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 299 | |||||||||
| Sequence: |
aatcattcaacaaagttgttacaaacattaccaggaaaagcatataatgcgtaaaagttaTgaagtcggtatttcacctaa -35 -10 +1 |
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| Evidence: |
[ICWHO] [TIM] |
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| Reference(s): |
[1] Cunningham L., et al., 1998 [6] Huerta AM., et al., 2003 [2] Wilde RJ., et al., 1986 |
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| Terminator(s) | ||||||||||
| Type: | rho-independent | |||||||||
| Sequence: | ttaggcatatAAAAATCAACCCGCCATATGAACGGCGGGTTAAAATATttacaactta | |||||||||
| Reference(s): | [5] Bhayana V., et al., 1984 | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | ArcA-phosphorylated | repressor | gltAp1 | 754807 | 754821 | -47.0 | tgacaatcatTCAACAAAGTTGTTAcaaacattac | nd | [EME], [GEA], [AIBSPD], [APIORCISFBSCS], [BCE], [CCE] | [3], [11], [12], [13], [14], [15] |
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| remote | CRP-cyclic-AMP | activator | gltAp1 | 754864 | 754886 | -107.5 | gttttatcctGAACAGTGATCCAGGTCACGATAacaacattta | nd | [GEA], [AIBSCS], [BCE] | [7], [8], [9], [10] |
| RNA cis-regulatory element | |
|---|
| Regulation, transcriptional elongation | |
| Attenuator type: | Translational |
| Strand: | reverse |
| Evidence: | [ICA] Inferred by computational analysis |
| Reference(s): | [17] Merino E, et al., 2005 |
| Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
|---|---|---|---|---|---|
| terminator | -12.2 | 754468 | 754515 | cgaaggcaaaTTTAAGTTCCGGCAGTCTTACGCAATAAGGCGCTAAGGAGACCTTAAatggctgata |
| Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
| Reference(s) |
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|---|---|
[HIPP] Human inference of promoter position