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Name: | cadBA | ||||||||||
Gene(s): | cadA, cadB Genome Browser M3D Gene expression COLOMBOS | ||||||||||
Note(s): | In RegulonDB, there was one transcription unit, cadCBA. Current information suggests that there are two transcription units, cadC and cadBA. Regulation has been described Auger EA, Redding KE, Plumb T, Childs LC, Meng SY, Bennett GN,1989. Meng SY, Bennett GN,1992. Shi X,1993. Takayama M,1994. Neely MN, Dell CL, Olson ER,1994. Dell CL,1994. Shi X,1995. Reams SG, Lee N, Mat-Jan F, Clark DP,1997. Rowbury RJ,1997. Prüss BM, Markovic D, Matsumura P,1997. Kikuchi Y,1998. Kikuchi Y,1998. Neely MN,1996. Popkin PS, Maas WK,1980. Beretskene SIa, Bruzgulis PA, Ragavichus AB,1980. Watson N,1992. Based on quantitative analysis, a model was proposed for the Cad system by Fritz et al. Fritz G,2009 The Cad system is conditionally activated by low pH only when a high lysine concentration is available. Lysine inhibits the repressive effects of the lysine permease LysP on the receptor CadC, while low pH activates CadC directly. The active form of CadC activates transcription of the cadBA operon. The Cad system counteracts the elevated H+ concentration by converting lysine to cadaverine under the consumption of H+ and exporting cadaverine in exchange for external lysine. Finally, it is believed that external cadaverine deactivates CadC Fritz G,2009 The cadBA operon displays a transient response, even when the conditions for its induction persist. The Cad system supports negative feedback by external cadaverine as the origin of the transient response Fritz G,2009 LysP indirectly regulates the cadBA operon by sequestering the CadC activator in the absence of Lys, but not in its presence Neely MN, Dell CL, Olson ER,1994. Tetsch L,2008. Marbaniang CN,2011 IHF induces amino acid-dependent acid resistance (AR) by activating cadBA translation at acidic pH Bi H, Zhang C,2014 |
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Evidence: | [EXP-IMP-POLAR-MUTATION] Polar mutation | ||||||||||
Reference(s): | [1] Watson N., et al., 1992 | ||||||||||
Promoter | |||||||||||
Name: | cadBp | ||||||||||
+1: | 4360106 | ||||||||||
Sigma Factor: | Sigma70 Sigmulon | ||||||||||
Distance from start of the gene: | 75 | ||||||||||
Sequence: |
tttgtgttatttcacctaatctttaggattaatccttttttcgtgagtaatcttatcgccAgtttggtctggtcaggaaat -35 -10 +1 |
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Evidence: |
[COMP-AINF] [COMP-HINF] [COMP-HINF-POSITIONAL-IDENTIFICATION] [EXP-IDA-TRANSCRIPTION-INIT-MAPPING] [EXP-IMP] |
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Reference(s): |
[2] Huerta AM., et al., 2003 [1] Watson N., et al., 1992 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
remote | ArcA-phosphorylated | repressor | cadBp | 4360278 | 4360292 | -179.0 | ataatttttaTTACATAAATTTAACcagagaatgt | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS] | W | [6] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
nd | CadC | activator | cadBp | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | W | [1], [4], [9] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
nd | GadE-RcsB | activator | cadBp | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | W | [7], [8] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
nd | GadX | activator | cadBp | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS] | W | [7] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
nd | Lrp | activator | cadBp | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | W | [10] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | ||||||||
nd | OmpR | repressor | cadBp | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | W | [11] |
Name: | cadA |
Gene(s): | cadA Genome Browser M3D Gene expression COLOMBOS |
Note(s): | During acid stress, RavA antagonizes the inhibitory effect of ppGpp on CadA activity El Bakkouri M, Gutsche I, Kanjee U, Zhao B, Yu M, Goret G, Schoehn G, Burmeister WP, Houry WA,2010. The mRNA produced by the cadA gene has been observed mainly in the poles of the cell Kannaiah S, Livny J, Amster-Choder O,2019. Fluoroquinolones and -lactams increased cadA expression, while an aminoglycoside (amikacin) decreased such expression Akhova A,. |
Promoter | |
Name: | cadAp |
+1: | Unknown |
Evidence: | [EXP-IEP] |
Reference(s): | [12] Zaslaver A., et al., 2006 |
Reference(s) |
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