RegulonDB RegulonDB 10.10: Operon Form
   

metC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: metC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: metC
Synonym(s): OP00266
Gene(s): metC   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Otsuka J., et al., 1996
Promoter
Name: metCp
+1: 3152075
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 161
Sequence: ctgcgcataataatatcaaaacgacgtcgaattgatagtcgttctcattactatttgcatActgccgtacctttgctttct
                          -35                    -10        +1                   
Evidence: [AIPP]
[ICWHO]
Reference(s): [2] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[MetJ,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd MetJ-S-adenosyl-L-methionine repressor metCp nd nd nd nd nd [BPP] [1], [3]


Evidence    

 [AIPP] Automated inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [BPP] Binding of purified proteins


Reference(s)    

 [1] Otsuka J., Watanabe H., Mori KT., 1996, Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli., J Theor Biol 178(2):183-204

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Wild CM., McNally T., Phillips SE., Stockley PG., 1996, Effects of systematic variation of the minimal Escherichia coli met consensus operator site: in vivo and in vitro met repressor binding., Mol Microbiol 21(6):1125-35

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