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Name: | codBA |
Synonym(s): | OP00277 |
Gene(s): | codB, codA Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The expression of the codBA operon, whose genes overlap, is induced under nitrogen-limited growth conditions and repressed by purines or pyrimidines. This induction and repression are mediated by NAC and PurR proteins, respectively Muse WB,2003. Danielsen S,1992. |
Evidence: | [ITC] Inferred through co-regulation [PM] Polar mutation |
Reference(s): | [1] Danielsen S., et al., 1992 |
Promoter | |
Name: | codBp |
+1: | 354884 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 38 |
Sequence: |
aaaaatatatttccccacgaaaacgattgctttttatcttcagatgaatagaatgcggcgGattttttgggtttcaaacag -35 -10 +1 |
Note(s): | There are two codBA transcriptional start positions, G7 and A8, relative to the -10 box. A8 always leads to reiterative transcription and the synthesis of transcripts with sequence AUUUUn, which are not extended downstream to include the codBA structural gene sequences. The G7 does not engage in reiterative transcription, which permits them to be extended downstream to generate productive codBA mRNA Qi F,1995. |
Evidence: |
[HIPP] [TIM] |
Reference(s): | [2] Qi F., et al., 1995 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | Nac1 | activator | codBp | 354819 | 354833 | -58.0 | gcactcattcATATAAAAAATATATttccccacga | nd | [AIBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(CHIP-SV/SM)], [CV(GEA/ROMA)], [CV(GEA/ROMA/SM)], [GEA], [SM] | [3], [4] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | PurR-hypoxanthine1 | repressor | codBp | 354840 | 354855 | -36.5 | atatttccccACGAAAACGATTGCTTtttatcttca | nd | [AIBSCS], [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] | [1], [5], [6] |
Note(s): |
1In a footprinting analysis the Nac protein of Klebsiella pneumoniae was used.1This PurR-binding site overlaps the -35 box of the codBp ptomoter Danielsen S,1992.1In a footprinting analysis the Nac protein of Klebsiella pneumoniae was used. 2This PurR-binding site overlaps the -35 box of the codBp ptomoter Danielsen S,1992. |
Reference(s) |
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