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Name: | zwf |
Synonym(s): | OP00294 |
Gene(s): | zwf Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The expresion of zwf gene is induced under oxidative stress Lu C,2003 and under acidic growth conditions in either aerobiosis or microaerobiosis Marzan LW,2013 MarA, SoxS, and Rob activate zwf trancription in vitro; all three depend on the same zwf sequences for activation. However, only SoxS and MarA induce glucose 6-phosphate dehydrogense activity (zwf product) in vivo. The expression of the zwf gene was increased in mutants for two genes that encode two terminal oxidases, cyoA and cydB, and in mutants of two transcriptional regulators, Fnr and Fur Kumar R,2011 The transcription of the gene zwf is enhanced under high oxygen saturation (300%) Baez A,2013 |
Reference(s): | [1] Ariza RR., et al., 1995 |
Promoter | |
Name: | zwfp |
+1: | 1936376 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 62 |
Sequence: |
tcgcacgggtggataagcgtttacagttttcgcaagctcgtaaaagcagtacagtgcaccGtaagaaaattacaagtatac -35 -10 +1 |
Note(s): | Activation of this promoter required the C-terminal domain of the RNA polymerase α-subunit. |
Evidence: | [TIM] |
Reference(s): |
[2] Lisser S., et al., 1993 [3] Rowley DL., et al., 1991 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | MarA | activator | zwfp | 1936420 | 1936439 | -54.0 | gcttttcccgTAATCGCACGGGTGGATAAGcgtttacagt | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4], [5], [6], [7], [8] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | SoxS1 | activator | zwfp | 1936418 | 1936437 | -51.5 | ttttcccgtaATCGCACGGGTGGATAAGCGtttacagttt | nd | [APIORCISFBSCS], [BPP], , [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [IHBCE], , [SM] | [7], [8], [9], [10], [11], [12] |
Note(s): |
1Rob binding to zwf induced a bend of ~30°.1SoxS binding to zwf induced a bend of ~50°.2Rob binding to zwf induced a bend of ~30°. 3SoxS binding to zwf induced a bend of ~50°. |
Reference(s) |
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