RegulonDB RegulonDB 10.7: Operon Form
   

gntRKU operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: gntRKU
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: gntK
Gene(s): gntK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Izu H., et al., 1997
Promoter
Name: gntKp
+1: 3577645
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 53
Sequence: cttatacacttaaggcatggatggatattgcttctgatattgtccggctggacaatgttaCcgataacagttacccgtaac
                            -35                    -10      +1                   
Note(s): Transcription from the gntKp promoter seems to be attenuated at the potential stem-loop structure in front of the gntU gene.
Evidence: [TIM]
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996
Terminator(s)
Type: rho-independent
Sequence: catgactaaaAACAGCAGCAGTAAAACAGACCCTACTGCTGTTaaaacaagcg
Reference(s): [1] Izu H., et al., 1997
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator gntKp 3577703 3577724 -68.5 ttaagcccacAAATTTGAAGTAGCTCACACTTatacacttaa nd [APIORCISFBSCS], [BCE], [GEA] [1], [2], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal GntR repressor gntKp 3577621 3577640 15.5 tgttaccgatAACAGTTACCCGTAACATTTttaattcttg nd [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [3], [4], [5]
proximal GntR repressor gntKp 3577634 3577653 2.5 tccggctggaCAATGTTACCGATAACAGTTacccgtaaca nd [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [2], [3], [4], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal IdnR-5-ketogluconate1 repressor gntKp 3577623 3577638 15.5 ttaccgataaCAGTTACCCGTAACATttttaattct nd [GEA] [4]
proximal IdnR-5-ketogluconate repressor gntKp 3577636 3577651 2.5 cggctggacaATGTTACCGATAACAGttacccgtaa nd [GEA] [4]
Note(s): 1IdnR negatively controls the gntK operon, presumably by binding to GntR-binding elements when GntR is released from the operator by interaction with gluconate.
4IdnR negatively controls the gntK operon, presumably by binding to GntR-binding elements when GntR is released from the operator by interaction with gluconate.


Transcription unit          
Name: gntKU
Synonym(s): OP00323
Gene(s): gntU, gntK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996
Promoter
Name: gntKp
+1: 3577645
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 53
Sequence: cttatacacttaaggcatggatggatattgcttctgatattgtccggctggacaatgttaCcgataacagttacccgtaac
                            -35                    -10      +1                   
Note(s): Transcription from the gntKp promoter seems to be attenuated at the potential stem-loop structure in front of the gntU gene.
Evidence: [TIM]
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996
Terminator(s)
Type: rho-independent
Sequence: tcgaaaagaaCCCGGTAGCGTCACAACTACCGGGcgaacaaact
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator gntKp 3577703 3577724 -68.5 ttaagcccacAAATTTGAAGTAGCTCACACTTatacacttaa nd [APIORCISFBSCS], [BCE], [GEA] [1], [2], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal GntR repressor gntKp 3577621 3577640 15.5 tgttaccgatAACAGTTACCCGTAACATTTttaattcttg nd [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [3], [4], [5]
proximal GntR repressor gntKp 3577634 3577653 2.5 tccggctggaCAATGTTACCGATAACAGTTacccgtaaca nd [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [2], [3], [4], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal IdnR-5-ketogluconate1 repressor gntKp 3577623 3577638 15.5 ttaccgataaCAGTTACCCGTAACATttttaattct nd [GEA] [4]
proximal IdnR-5-ketogluconate repressor gntKp 3577636 3577651 2.5 cggctggacaATGTTACCGATAACAGttacccgtaa nd [GEA] [4]
Note(s): 1IdnR negatively controls the gntK operon, presumably by binding to GntR-binding elements when GntR is released from the operator by interaction with gluconate.
4IdnR negatively controls the gntK operon, presumably by binding to GntR-binding elements when GntR is released from the operator by interaction with gluconate.


Transcription unit       
Name: gntR
Gene(s): gntR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [2] Tong S., et al., 1996
Promoter
Name: gntRp2
+1: 3578818
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 92
Sequence: gcttccggggttttgccgcgtcgttagcacaatgcgatgcaattgatttagtgtatatctAataattgtaaacaagcactg
                        -35                      -10        +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [2] Tong S., et al., 1996
Terminator(s)
Type: rho-independent
Sequence: aagaattaaaAATGTTACGGGTAACTGTTATCGGTAACATTgtccagccgg


Transcription unit       
Name: gntR
Gene(s): gntR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [2] Tong S., et al., 1996
Promoter
Name: gntRp3
+1: 3578862
Distance from start of the gene: 136
Sequence: tttttgcaggcttcctcgctcgctccggtcgcgtgctgatgtacgcttccggggttttgcCgcgtcgttagcacaatgcga
Evidence: [HIPP]
[TIM]
Reference(s): [2] Tong S., et al., 1996
Terminator(s)
Type: rho-independent
Sequence: aagaattaaaAATGTTACGGGTAACTGTTATCGGTAACATTgtccagccgg


Transcription unit       
Name: gntR
Gene(s): gntR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [2] Tong S., et al., 1996
Promoter
Name: gntRp4
+1: 3578880
Distance from start of the gene: 154
Sequence: gcatctttgaagcctgcctttttgcaggcttcctcgctcgctccggtcgcgtgctgatgtAcgcttccggggttttgccgc
Evidence: [TIM]
Reference(s): [2] Tong S., et al., 1996
Terminator(s)
Type: rho-independent
Sequence: aagaattaaaAATGTTACGGGTAACTGTTATCGGTAACATTgtccagccgg


Transcription unit       
Gene(s): gntU   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[IC] Inferred by curator
Reference(s): [6] Huerta AM., et al., 2003
[1] Izu H., et al., 1997
Terminator(s)
Type: rho-independent
Sequence: tcgaaaagaaCCCGGTAGCGTCACAACTACCGGGcgaacaaact
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996


Transcription unit       
Name: gntRKU
Gene(s): gntU, gntK, gntR   Genome Browser M3D Gene expression COLOMBOS
Note(s): Transcription from the gntRp promoter seems to be terminated by the presence of GntR around the GntR-binding site, which overlaps with the gntKp promoter.
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Izu H., et al., 1997
Terminator(s)
Type: rho-independent
Sequence: tcgaaaagaaCCCGGTAGCGTCACAACTACCGGGcgaacaaact
Reference(s): [1] Izu H., et al., 1997
[2] Tong S., et al., 1996





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