RegulonDB RegulonDB 10.9: Operon Form
   

atpIBEFHAGDC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: atpIBEFHAGDC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: atpBEFHAGDC
Gene(s): atpC, atpD, atpG, atpA, atpH, atpF, atpE, atpB   Genome Browser M3D Gene expression COLOMBOS
Note(s): FNR represses atpB gene expression under anaerobiosis Salmon K,2003. Under nitrogen-rich growth conditions, the expression of the atpA gene increased in a mutant for the transcriptional regulator Fnr. However, under nitrogen-limited growth conditions, the gene expression was decreased. Under both nitrogen-limited and nitrogen-rich growth conditions, the expression of atpA increased in the mutants for cyoA and Fur. However, it is unknown if the effects of the transcriptional regulators act directly on the gene expression; also, it is unknown which of the three promoters that transcribe the gene could be regulated by the regulators Kumar R,2011
The atpB mRNA is the most unstable region within the atp operon, mainly in the residues 93-171. This instability causes a toxic phenotype in the cell Arechaga I,2003.
The expression of the gene atpA is increased under acidic growth conditions in either aerobiosis or microaerobiosis Marzan LW,2013
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Jones HM., et al., 1983
[2] Nielsen J., et al., 1984
Promoter
Name: atpBp2
+1: 3922134
Distance from start of the gene: 83
Sequence: gttctggcgatgttggtgttactggtggtggcgttggcggttttaaaggcggtattcttgCcgctgatcgttacgtgggtt
Note(s): atpBp2 is a weak promoter; therefore, it cannot be excluded that the transcriptional start site represents a cleavage artifact Nielsen J,1984.
Evidence: [TIM]
Reference(s): [2] Nielsen J., et al., 1984
Terminator(s)
Type: rho-independent
Sequence: cgcaaaaaaaAGCCAGCCTGTTTCCAGACTGGCttttgtgctt
Reference(s): [3] Walker JE., et al., 1984


Transcription unit       
Name: atpBEFHAGDC
Gene(s): atpC, atpD, atpG, atpA, atpH, atpF, atpE, atpB   Genome Browser M3D Gene expression COLOMBOS
Note(s): FNR represses atpB gene expression under anaerobiosis Salmon K,2003. Under nitrogen-rich growth conditions, the expression of the atpA gene increased in a mutant for the transcriptional regulator Fnr. However, under nitrogen-limited growth conditions, the gene expression was decreased. Under both nitrogen-limited and nitrogen-rich growth conditions, the expression of atpA increased in the mutants for cyoA and Fur. However, it is unknown if the effects of the transcriptional regulators act directly on the gene expression; also, it is unknown which of the three promoters that transcribe the gene could be regulated by the regulators Kumar R,2011
The atpB mRNA is the most unstable region within the atp operon, mainly in the residues 93-171. This instability causes a toxic phenotype in the cell Arechaga I,2003.
atpB is upregulated and downregulated in response to chlortetracycline (CTC) and nalidixic acid (NA), respectively, in parallel and in the opposite direction with ompC gene Lin X,2012 these changes are regulated by CpxR Lin X,2012
The expression of the gene atpA is increased under acidic growth conditions in either aerobiosis or microaerobiosis Marzan LW,2013
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Jones HM., et al., 1983
[2] Nielsen J., et al., 1984
Promoter
Name: atpBp1
+1: 3922270
Distance from start of the gene: 219
Sequence: cgtctctgcaataagcgggggcctggcagtctttctgcctaacgttttgtttatgatattTgcctggcgtcaccaggcgca
Note(s): atpBp1 is a weak promoter, and therefore it cannot be excluded that the transcriptional start site represents a cleavage artifact Nielsen J,1984.
Evidence: [TIM]
Reference(s): [2] Nielsen J., et al., 1984
Terminator(s)
Type: rho-independent
Sequence: cgcaaaaaaaAGCCAGCCTGTTTCCAGACTGGCttttgtgctt
Reference(s): [3] Walker JE., et al., 1984


Transcription unit       
Name: atpIBEFHAGDC
Gene(s): atpC, atpD, atpG, atpA, atpH, atpF, atpE, atpB, atpI   Genome Browser M3D Gene expression COLOMBOS
Note(s): FNR represses atpB gene expression under anaerobiosis Salmon K,2003. Under nitrogen-rich growth conditions, the expression of the atpA gene increased in a mutant for the transcriptional regulator Fnr. However, under nitrogen-limited growth conditions, the gene expression was decreased. Under both nitrogen-limited and nitrogen-rich growth conditions, the expression of atpA increased in the mutants for cyoA and Fur. However, it is unknown if the effects of the transcriptional regulators act directly on the gene expression; also, it is unknown which of the three promoters that transcribe the gene could be regulated by the regulators Kumar R,2011
The atpB mRNA is the most unstable region within the atp operon, mainly in the residues 93-171. This instability causes a toxic phenotype in the cell Arechaga I,2003.
The expression of the gene atpA is increased under acidic growth conditions in either aerobiosis or microaerobiosis Marzan LW,2013
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Jones HM., et al., 1983
[4] Kasimoglu E., et al., 1996
[2] Nielsen J., et al., 1984
[5] Porter AC., et al., 1983
Promoter
Name: atpIp
+1: 3922525
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 85
Sequence: ttattcaccttttggctacttattgtttgaaatcacgggggcgcaccgtataatttgaccGctttttgatgcttgactcta
                           -35                   -10        +1                   
Evidence: [ICWHO]
[TIM]
Reference(s): [6] Huerta AM., et al., 2003
[1] Jones HM., et al., 1983
[2] Nielsen J., et al., 1984
Terminator(s)
Type: rho-independent
Sequence: cgcaaaaaaaAGCCAGCCTGTTTCCAGACTGGCttttgtgctt
Reference(s): [3] Walker JE., et al., 1984





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