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Name: | hyaABCDEF |
Gene(s): | hyaA, hyaB, hyaC, hyaD, hyaE, hyaF Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The hyaABCDEF operon is induced under anaerobiosis and repressed by nitrate Richard DJ,1999 ArcA and Appy antagonize the IscR repression effect under anaerobic conditions Nesbit AD,2012 |
Evidence: | [BTEI] Boundaries of transcription experimentally identified [ITC] Inferred through co-regulation |
Reference(s): |
[1] Maciag A., et al., 2011 [2] Menon NK., et al., 1990 [3] Menon NK., et al., 1991 |
Promoter | |
Name: | hyaAp |
+1: | 1031984 |
Sigma Factor: | Sigma70, Sigma38 |
Distance from start of the gene: | 155 |
Sequence: |
aaaagataaatccacacagtttgtattgttttgtgcaaaagtttcactacgctttattaaCaatactttctggcgacgtgc -35 -10 +1 |
Note(s): | The hyaA promoter does not have much similarity to the consensus -10 and -35 promoter sequences for σ70, as shown by Richard DJ,1999. But, as reported in Atlung T,1997, a correlation with σ38 and hya operon expression has been proved under different conditions, so the promoter seems to be σ38. |
Evidence: |
[HIPP] [IMP] [TIM] |
Reference(s): |
[4] Atlung T., et al., 1997 [5] Richard DJ., et al., 1999 |
Terminator(s) | |
Type: | rho-independent |
Sequence: | ccgacgtaaaAAGACGGTAAGTATCGCTTTCAGTCTTatgaatatcg |
Reference(s): | [2] Menon NK., et al., 1990 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | ArcA-Phosphorylated1 | activator | hyaAp | 1031910 | 1031924 | -67.0 | aaaaataggtCCATTTTTATCGCTAaaagataaat | nd | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5], [6] |
proximal | ArcA-Phosphorylated | activator | hyaAp | 1031966 | 1031988 | -7.5 | gtgcaaaagtTTCACTACGCTTTATTAACAATActttctggcg | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [9] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | IscR | repressor | hyaAp | 1031930 | 1031954 | -42.0 | cgctaaaagaTAAATCCACACAGTTTGTATTGTTTtgtgcaaaag | nd | [BPP], [GEA] | [8] |
proximal | IscR | repressor | hyaAp | 1031933 | 1031957 | -39.0 | taaaagataaATCCACACAGTTTGTATTGTTTTGTgcaaaagttt | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [9] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | NarL-Phosphorylated | repressor | hyaAp | 1031966 | 1031981 | -10.0 | gtgcaaaagtTTCACTACGCTTTATTaacaatactt | nd | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] |
proximal | NarL-Phosphorylated | repressor | hyaAp | 1031982 | 1031997 | 7.0 | acgctttattAACAATACTTTCTGGCgacgtgcgcc | nd | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | NarP-Phosphorylated | repressor | hyaAp | 1031966 | 1031981 | -10.0 | gtgcaaaagtTTCACTACGCTTTATTaacaatactt | nd | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] |
proximal | NarP-Phosphorylated | repressor | hyaAp | 1031982 | 1031997 | 7.0 | acgctttattAACAATACTTTCTGGCgacgtgcgcc | nd | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | YdeO | activator | hyaAp | 1031912 | 1031935 | -61.0 | aaataggtccATTTTTATCGCTAAAAGATAAATCcacacagttt | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [IHBCE] | [7] |
Note(s): |
1AppY actives the transcription of the hyaABCDEF operon during anaerobic growth.1ArcA actives the transcription of the hyaABCDEF operon during anaerobic growth. 1ArcA actives the transcription of the hyaABCDEF operon during anaerobic growth. 11AppY actives the transcription of the hyaABCDEF operon during anaerobic growth. |
Reference(s) |
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