RegulonDB RegulonDB 10.10: Operon Form

phoBR operon and associated TUs in Escherichia coli K-12 genome

Name: phoBR
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: phoBR
Synonym(s): OP00072, phoB
Gene(s): phoB, phoR   Genome Browser M3D Gene expression COLOMBOS
Note(s): The expression of the operon phoBR is increased under phosphate starvation Ulu?eker C, Torres-Bacete J, García JL, Hanczyc MM, Nogales J, Kahramano?ullar? O,2019 and acidic growth conditions in aerobiosis but not in microaerobiosis Marzan LW,2013 The increased expression appears to be caused by the transcription factor PhoB Marzan LW,2013
The transcript that contains phoB is increased after σE induction, as observed in high-throughput analysis of gene expression Lacoux C,2020.
Reference(s): [1] Wanner BL., et al., 1987
Name: phoBp
+1: 417101
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 41
Sequence: tgaagatatgtgcgacgagcttttcataaatctgtcataaatctgacgcataatgacgtcGcattaatgatcgcaacctat
                       -35                       -10        +1                   
Evidence: [HIPP]
Reference(s): [2] Huerta AM., et al., 2003
[3] Makino K., et al., 1986
Type: rho-independent
Reference(s): [4] Feng CQ., et al., 2019
[5] Lesnik EA., et al., 2001
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal PhoB-phosphorylated activator phoBp 417061 417079 -31.0 tgcgacgagcTTTTCATAAATCTGTCATAaatctgacgc nd [GEA], [APIORCISFBSCS], [BPP] [6], [7]