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Name: | uvrB |
Gene(s): | uvrB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The full activity of the uvrB promoter region requires three promoters (uvrBp1, uvrBp2, and uvrBp3) and is repressed by both the DnaA and LexA proteins Wurihan,2018 In the absence of the SOS response, both DnaA and LexA repress transcription of the uvrB gene and function independently of each other, but in an additive manner Wurihan,2018 |
Evidence: | [BTEI] Boundaries of transcription experimentally identified [LTED] Length of transcript experimentally determined |
Reference(s): | [1] Sancar GB., et al., 1982 |
Promoter | |
Name: | uvrBp3 |
+1: | 813152 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 374 |
Sequence: |
aggggctggagacagttatccactattcctgtggataaccatgtgtattagagttagaaaAcacgaggcaagcgagagaat -35 -10 +1 |
Note(s): | Transcription of uvrBp3 is indirectly inhibited by LexA. This transcript terminates within or near the LexA-binding site, which regulates uvrBp2, and it is possible that termination does not occur in vivo Sancar GB,1982 |
Evidence: | [TIM] |
Reference(s): | [1] Sancar GB., et al., 1982 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | DnaA-ATP | repressor | uvrBp3 | 813107 | 813115 | -41.0 | ctggagacagTTATCCACTattcctgtgg | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
proximal | DnaA-ATP2 | repressor | uvrBp3 | 813121 | 813129 | -27.0 | ccactattccTGTGGATAAccatgtgtat | nd | [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [ICA], [SM] | [2] |
proximal | DnaA-ATP | repressor | uvrBp3 | 813133 | 813141 | -15.0 | tggataaccaTGTGTATTAgagttagaaa | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | LexA1 | repressor | uvrBp3 | 813120 | 813136 | -24.5 | tccactattcCTGTGGATAACCATGTGtattagagtt | nd | [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [ICA], [SM] | [2] |
Note(s): |
2DnaA and LexA compete for binding to and regulation of the uvrBp3 promoter, as DnaA-box6 overlaps with LexA-box4. The transcription control of uvrBp3 largely depends on DnaA-box6 during the SOS response Wurihan,2018 1DnaA and LexA compete for binding to and regulation of the uvrBp3 promoter, as the DnaA-box6 overlaps with LexA-box4 during the SOS response Wurihan,20182DnaA and LexA compete for binding to and regulation of the uvrBp3 promoter, as DnaA-box6 overlaps with LexA-box4. The transcription control of uvrBp3 largely depends on DnaA-box6 during the SOS response Wurihan,2018 3DnaA and LexA compete for binding to and regulation of the uvrBp3 promoter, as the DnaA-box6 overlaps with LexA-box4 during the SOS response Wurihan,2018 |
Name: | uvrB |
Synonym(s): | OP00098 |
Gene(s): | uvrB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The full activity of the uvrB promoter region requires three promoters (uvrBp1, uvrBp2, and uvrBp3) and is repressed by both the DnaA and LexA proteins Wurihan,2018 In the absence of the SOS response, both DnaA and LexA repress transcription of the uvrB gene and function independently of each other, but in an additive manner Wurihan,2018 |
Evidence: | [LTED] Length of transcript experimentally determined |
Reference(s): |
[1] Sancar GB., et al., 1982 [3] Schendel PF., et al., 1982 |
Promoter | |
Name: | uvrBp2 |
+1: | 813462 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 64 |
Sequence: |
ttacgctgtatcagaaatattatggtgatgaactgtttttttatccagtataatttgttgGcataattaagtacgacgagt -35 -10 +1 |
Note(s): | Transcription of uvrBp3 is indirectly inhibited by LexA. This transcript terminates within or near the LexA-binding site, which regulates uvrBp2, and it is possible that termination does not occur in vivo Sancar GB,1982 |
Evidence: | [TIM] |
Reference(s): | [1] Sancar GB., et al., 1982 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | DnaA-ATP | repressor | uvrBp2 | 813310 | 813318 | -148.0 | tcttgacaaaTGTTAAAAAagccgttgct | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
remote | DnaA-ATP | repressor | uvrBp2 | 813330 | 813338 | -128.0 | gccgttgcttTGGGGATAAcccggtaagg | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
proximal | DnaA-ATP | repressor | uvrBp2 | 813377 | 813385 | -81.0 | acagagtaaaTTTTGCTCAtgattgacag | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
proximal | DnaA-ATP | repressor | uvrBp2 | 813442 | 813450 | -16.0 | aactgtttttTTATCCAGTataatttgtt | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | LexA | repressor | uvrBp2 | 813234 | 813250 | -220.5 | tattttttaaCTGGTTAGATAAATGCAatggcagtca | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
remote | LexA | repressor | uvrBp2 | 813287 | 813303 | -167.5 | tgccataaaaCTGTCATCACTCATCTTgacaaatgtt | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [ICA] | [2] |
proximal | LexA3 | repressor | uvrBp2 | 813434 | 813450 | -20.5 | tggtgatgaaCTGTTTTTTTATCCAGTataatttgtt | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [ICA], [SM] | [1], [2], [4] |
Note(s): |
3LexA binds tightly to LexA-box1 at the uvrBp1 and uvrBp2 promoters, irrespective of the presence of DnaA, and this binding is important for the control of the uvrBp1 and uvrBp2 promoters Wurihan,20186LexA binds tightly to LexA-box1 at the uvrBp1 and uvrBp2 promoters, irrespective of the presence of DnaA, and this binding is important for the control of the uvrBp1 and uvrBp2 promoters Wurihan,2018 |
Name: | uvrB |
Gene(s): | uvrB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The full activity of the uvrB promoter region requires three promoters (uvrBp1, uvrBp2, and uvrBp3) and is repressed by both the DnaA and LexA proteins Wurihan,2018 In the absence of the SOS response, both DnaA and LexA repress transcription of the uvrB gene and function independently of each other, but in an additive manner Wurihan,2018 |
Evidence: | [LTED] Length of transcript experimentally determined |
Reference(s): | [1] Sancar GB., et al., 1982 |
Promoter | |
Name: | uvrBp1 |
+1: | 813493 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 33 |
Sequence: |
actgtttttttatccagtataatttgttggcataattaagtacgacgagtaaaattacatAcctgcccgcccaactccttc -35 -10 +1 |
Evidence: | [TIM] |
Reference(s): | [1] Sancar GB., et al., 1982 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | LexA1 | repressor | uvrBp1 | 813434 | 813450 | -51.5 | tggtgatgaaCTGTTTTTTTATCCAGTataatttgtt | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [ICA], [SM] | [1], [2], [4] |
Note(s): | 1LexA binds tightly to LexA-box1 at the uvrBp1 and uvrBp2 promoters, irrespective of the presence of DnaA, and this binding is important for the control of the uvrBp1 and uvrBp2 promoters Wurihan,20181LexA binds tightly to LexA-box1 at the uvrBp1 and uvrBp2 promoters, irrespective of the presence of DnaA, and this binding is important for the control of the uvrBp1 and uvrBp2 promoters Wurihan,2018 |
Reference(s) |
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