RegulonDB RegulonDB 10.8: Operon Form
   

cysK operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: cysK
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: cysK
Gene(s): cysK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[IC] Inferred by curator
Reference(s): [1] Byrne CR., et al., 1988
[2] Mendoza-Vargas A., et al., 2009
Promoter
Name: cysKp2
+1: 2532344
Distance from start of the gene: 65
Sequence: ttattccatcttgcatgtcattatttcccttctgtatatagatatgctaaatccttacttCcgcatattctctgagcgggt
Evidence: [HTIM]
Reference(s): [2] Mendoza-Vargas A., et al., 2009
Terminator(s)
Type: rho-independent
Sequence: gcgtaaaaaaGCACCTTTTTAGGTGCttttttgtgg
Reference(s): [1] Byrne CR., et al., 1988


Transcription unit          
Name: cysK
Synonym(s): OP00107
Gene(s): cysK   Genome Browser M3D Gene expression COLOMBOS
Note(s): cysK expression is regulated negatively by the OmpR transcriptional regulator and is induced by CysE, an enzyme involved in the synthesis of O-acetyl-L-serine from L-serine and by addition of lithium ions 22092684.
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Byrne CR., et al., 1988
Promoter
Name: cysKp1
+1: 2532377
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 32
Sequence: gtatatagatatgctaaatccttacttccgcatattctctgagcgggtatgctacctgttGtatcccaatttcatacagtt
                      -35                       -10         +1                   
Evidence: [CV(RS-EPT-CBR)]
[CV(TIM)]
[RS-EPT-CBR]
[TIM]
Reference(s): [1] Byrne CR., et al., 1988
[2] Mendoza-Vargas A., et al., 2009
[3] Salgado H, et al., 2012
Terminator(s)
Type: rho-independent
Sequence: gcgtaaaaaaGCACCTTTTTAGGTGCttttttgtgg
Reference(s): [1] Byrne CR., et al., 1988
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CysB-O-acetyl-L-serine activator cysKp1 2532277 2532318 -79.0 gtggcttatgCCGCCCCTTATTCCATCTTGCATGTCATTATTTCCCTTCTGTatatagatat nd [APIORCISFBSCS], [SM] [4]





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