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Name: | fadL | |||||||||
Synonym(s): | OP00109 | |||||||||
Gene(s): | fadL Genome Browser M3D Gene expression COLOMBOS | |||||||||
Note(s): | OmpR binds at least four regions of DNA near the fadL promoter, two upstream and two downstream from the transcriptional start site. Only the phosphorylated form of OmpR binds the DNA. It is not clear whether binding of OmpR to all four sites is necessary for repression, or whether binding to each site affects transcription in a different way. Cross talk has been observed between global regulators controlling the fatty acid transport genes Feng Y,2012 Although there are two FadR sites in both the fadL and fadD-sroD operons, these operons modestly regulate FadR expression, which shows that the number of binding sites does not determine regulatory strength Feng Y,2012 FadR and ArcA control fadL and fadD-sroD expression under anaerobic conditions, and their effects are additive Feng Y,2012 Under NlpE outer membrane lipoprotein overexpression, the transcription of the fadL gene is decreased Raivio TL,2013 |
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Evidence: | [IHBCE] Inferred by a human based on computational evidence | |||||||||
Reference(s): | [1] Black PN. 1991 | |||||||||
Promoter | ||||||||||
Name: | fadLp | |||||||||
+1: | 2461205 | |||||||||
Sigma Factor: | Sigma38 Sigmulon | |||||||||
Distance from start of the gene: | 101 | |||||||||
Sequence: |
tttgaaaaaagatagaaacatacttgcaacattccagctggtccgacctatactctcgccActggtctgatttctaagatg -35 -10 +1 |
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Evidence: |
[HIPP] [ICWHO] [IEP] [TIM] |
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Reference(s): |
[1] Black PN. 1991 [2] Farewell A., et al., 1998 [3] Higashitani A., et al., 1993 [4] Huerta AM., et al., 2003 [5] Kvint K., et al., 2000 [6] Lelong C., et al., 2007 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | ArcA-phosphorylated | repressor | fadLp | 2461160 | 2461174 | -38.0 | aaaaagatagAAACATACTTGCAACattccagctg | nd | [AIBSCS], [BPP] | nd |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | CRP-cyclic-AMP | activator | fadLp | 2461037 | 2461059 | -157.5 | gcaaaatcggATAAGTGACCGAAATCACACTTAaaaatgatct | nd | [GEA], [BPP] | [10] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | FadR | repressor | fadLp | 2461180 | 2461196 | -17.0 | gcaacattccAGCTGGTCCGACCTATActctcgccac | nd | [GEA], [APIORCISFBSCS], [BCE], [BPP] | [10] |
proximal | FadR | repressor | fadLp | 2461205 | 2461221 | 9.0 | tactctcgccACTGGTCTGATTTCTAAgatgtacctc | nd | [APIORCISFBSCS], [BCE], [BPP] | [10] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | OmpR-phosphorylated | repressor | fadLp | 2461046 | 2461065 | -149.5 | gataagtgacCGAAATCACACTTAAAAATGatctaaaaca | nd | [APIORCISFBSCS], [SM] | nd |
proximal | OmpR-phosphorylated | repressor | fadLp | 2461135 | 2461154 | -60.5 | atcgcgtttcTTAGATCATATTTGAAAAAAgatagaaaca | nd | [GEA], [APIORCISFBSCS] | [3] |
remote | OmpR-phosphorylated | repressor | fadLp | 2461264 | 2461283 | 69.5 | gttacagcacGTAACATAGTTTGTATAAAAataaatcatt | nd | [GEA], [APIORCISFBSCS] | [3] |
remote | OmpR-phosphorylated | repressor | fadLp | 2461314 | 2461333 | 119.5 | tcatgagccaGAAAACCCTGTTTACAAAGTctgctctcgc | nd | [GEA], [APIORCISFBSCS] | [3] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | PhoP-phosphorylated | activator | fadLp | 2461005 | 2461023 | -191.5 | ttccggaaagTGCTGCTCCAGTTGTTAATtctgcaaaat | nd | [GEA], [AIBSCS] | [9] |
Evidence: | [GEA] Gene expression analysis |
Reference(s): | [5] Kvint K., et al., 2000 |
Reference(s) |
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