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| Operon |  |
|---|---|
| Name: | tyrP |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | tyrP |
| Gene(s): | tyrP Genome Browser M3D Gene expression COLOMBOS |
| Evidence: | [AISDTU] Automated inference that a single-gene directon is a transcription unit [BTEI] Boundaries of transcription experimentally identified |
| Reference(s): | [1] Kasian PA., et al., 1986 |
| Promoter | |
| Name: | tyrPp2 |
| +1: | 1989502 |
| Distance from start of the gene: | 179 |
| Sequence: |
ctgattcaatcatcatatttaacacttcatgaccgtgaatagagtccatcgtccctcctcAaaaaaagcctagcgtagcga |
| Evidence: | [TIM] |
| Reference(s): | [1] Kasian PA., et al., 1986 |
| Name: | tyrP |
| Synonym(s): | OP00124 |
| Gene(s): | tyrP Genome Browser M3D Gene expression COLOMBOS |
| Note(s): | When phenylalanine interacts with the TyrR protein, a dimer of this protein binds to a strong TyrR box located 64.5 bp upstream of the tyrPp1 promoter and activates the transcription of the tyrP gene Yang J,2004 It has been shown that the C-terminal domain of the RNA polymerase is involved in the activation of the tyrPp1 promoter by theTyrR protein Lawley B,1995 On the other hand, when tyrosine and ATP interact with the TyrR protein, the transcription of the gene is repressed through the binding of a TyrR hexamer to a weak TyrR box located 41.5 bp upstream of the tyrPp1 promoter and to the strong TyrR box mentioned earlier. In the repression process, the binding of RNA polymerase to the tyrPp promoter is blocked by TyrR hexamer Yang J,2004 |
| Evidence: | [AISDTU] Automated inference that a single-gene directon is a transcription unit [BTEI] Boundaries of transcription experimentally identified |
| Reference(s): | [2] Lawley B., et al., 1995 |
| Promoter | |
| Name: | tyrPp1 |
| +1: | 1989645 |
| Sigma Factor: | Sigma70 Sigmulon |
| Distance from start of the gene: | 36 |
| Sequence: |
ttacaccatatgtaacgtcggtttgacgaagcagccgttatgccttaacctgcgccgcagAtatcactcataaagatcgtc -35 -10 +1 |
| Evidence: |
[HIPP] [TIM] |
| Reference(s): | [2] Lawley B., et al., 1995 |
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | TyrR-phenylalanine1 | activator | tyrPp1 | 1989572 | 1989589 | -64.5 | tgctttttatTGTACATTTATATTTACAccatatgtaa | nd | [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [2], [3], [4] |
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | TyrR1 | repressor | tyrPp1 | 1989572 | 1989589 | -64.5 | tgctttttatTGTACATTTATATTTACAccatatgtaa | nd | [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [2], [3], [4] |
| proximal | TyrR-tyrosine2 | repressor | tyrPp1 | 1989595 | 1989612 | -41.5 | ttacaccataTGTAACGTCGGTTTGACGaagcagccgt | nd | [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [2], [3], [4] |
| Note(s): |
1The TyrR-binding site at position -64.5 from the promoter is a strong TyrR box that is involved in the activation and repression of tyrP gene transcription. The TyrR protein with phenylalanine only binds to this site to activate transcription, whereas the protein with tyrosine binds to this and another weak site (-41.5 from the promoter) to repress the transcription Yang J,20041The TyrR-binding site at position -64.5 from the promoter is a strong TyrR box that is involved in the activation and repression of tyrP gene transcription. The TyrR protein with phenylalanine only binds to this site to activate transcription, whereas the protein with tyrosine binds to this and another weak site (-41.5 from the promoter) to repress the transcription Yang J,2004 2The TyrR-binding site at position -41.5 from the promoter is a weak TyrR box that is involved in the repression of tyrP gene transcription. This, along with another site (-64.5 from the promoter), is required for the repression of tyrP gene expression by the TyrR protein in the presence of ATP and tyrosine Yang J,20041The TyrR-binding site at position -64.5 from the promoter is a strong TyrR box that is involved in the activation and repression of tyrP gene transcription. The TyrR protein with phenylalanine only binds to this site to activate transcription, whereas the protein with tyrosine binds to this and another weak site (-41.5 from the promoter) to repress the transcription Yang J,2004 2The TyrR-binding site at position -64.5 from the promoter is a strong TyrR box that is involved in the activation and repression of tyrP gene transcription. The TyrR protein with phenylalanine only binds to this site to activate transcription, whereas the protein with tyrosine binds to this and another weak site (-41.5 from the promoter) to repress the transcription Yang J,2004 3The TyrR-binding site at position -41.5 from the promoter is a weak TyrR box that is involved in the repression of tyrP gene transcription. This, along with another site (-64.5 from the promoter), is required for the repression of tyrP gene expression by the TyrR protein in the presence of ATP and tyrosine Yang J,2004 |
| Reference(s) |
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|---|---|
[TIM] Transcription initiation mapping