RegulonDB RegulonDB 10.8: Operon Form
   

fabA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: fabA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: fabA
Synonym(s): OP00130
Gene(s): fabA   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Cronan JE., et al., 1988
[2] Saito K., et al., 1995
Promoter
Name: fabAp
+1: 1016498
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 28
Sequence: actggtttattccgaactgatcggacttgttcagcgtacacgtgttagctatcctgcgtgCttcaataaaataaggcttac
                           -35                    -10       +1                   
Evidence: [HIPP]
Reference(s): [1] Cronan JE., et al., 1988
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FabR repressor fabAp 1016509 1016526 -19.5 ggacttgttcAGCGTACACGTGTTAGCTatcctgcgtg nd [AIBSCS], [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [4], [7], [8]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FadR activator fabAp 1016528 1016544 -38.0 gtttattccgAACTGATCGGACTTGTTcagcgtacac nd [APIORCISFBSCS], [BCE], [CV(GEA)], [GEA] [3], [4], [5], [6]




Reference(s)    

 [1] Cronan JE., Li WB., Coleman R., Narasimhan M., de Mendoza D., Schwab JM., 1988, Derived amino acid sequence and identification of active site residues of Escherichia coli beta-hydroxydecanoyl thioester dehydrase., J Biol Chem 263(10):4641-6

 [2] Saito K., Hamajima A., Ohkuma M., Murakoshi I., Ohmori S., Kawaguchi A., Teeri TH., Cronan JE., 1995, Expression of the Escherichia coli fabA gene encoding beta-hydroxydecanoyl thioester dehydrase and transport to chloroplasts in transgenic tobacco., Transgenic Res 4(1):60-9

 [3] DiRusso CC., Black PN., Weimar JD., 1999, Molecular inroads into the regulation and metabolism of fatty acids, lessons from bacteria., Prog Lipid Res 38(2):129-97

 [4] Feng Y., Cronan JE., 2011, Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters., Mol Microbiol 80(1):195-218

 [5] Gui L., Sunnarborg A., LaPorte DC., 1996, Regulated expression of a repressor protein: FadR activates iclR., J Bacteriol 178(15):4704-9

 [6] Henry MF., Cronan JE., 1992, A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding., Cell 70(4):671-9

 [7] McCue L., Thompson W., Carmack C., Ryan MP., Liu JS., Derbyshire V., Lawrence CE., 2001, Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes., Nucleic Acids Res 29(3):774-82

 [8] Zhang YM., Marrakchi H., Rock CO., 2002, The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli., J Biol Chem 277(18):15558-65


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