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Name: | malXY |
Synonym(s): | OP00176 |
Gene(s): | malX, malY Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The malY and malX genes are defined as part of the same operon according to their chromosomal positions, their induction pattern, and the polar effect on malY caused by an insertion in malX, but it is not clear whether malY is the last gene in this operon. In addition, the 5' portion of the malY gene contains stretches of sequences that would allow the formation of two stable stem-and-loop structures. The possible significance of these structures is unknown. |
Evidence: | [BTEI] Boundaries of transcription experimentally identified [PM] Polar mutation |
Reference(s): |
[1] Otsuka J., et al., 1996 [2] Reidl J., et al., 1991 |
Promoter | |
Name: | malXp |
+1: | 1699313 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 42 |
Sequence: |
tcgttgcgtaatgtgatttatgcctcactaaaatttgataaaacgttttatcttctcgcgCaatttactgaatccagattg -35 -10 +1 |
Evidence: |
[ICA] [TIM] |
Reference(s): |
[3] Lloyd GS., et al., 2008 [2] Reidl J., et al., 1991 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | CRP-cAMP1 | activator | malXp | 1699201 | 1699222 | -101.5 | tactccctgaTTATGTGACAGATAAAACGTTTtaccttttat | nd | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [3], [4] |
proximal | CRP-cAMP2 | activator | malXp | 1699261 | 1699282 | -41.5 | tatcgttgcgTAATGTGATTTATGCCTCACTAaaatttgata | nd | [AIBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [2], [3], [5], [6] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | MalI | repressor | malXp | 1699288 | 1699305 | -16.5 | cactaaaattTGATAAAACGTTTTATCTtctcgcgcaa | nd | [BCE], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [2], [5], [6] |
Note(s): |
1CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008 2CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,20081CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008 2CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008 |
Name: | malY |
Gene(s): | malY Genome Browser M3D Gene expression COLOMBOS |
Evidence: | [IEP] Inferred from expression pattern |
Reference(s): | [7] Li Z., et al., 2019 |
Promoter | |
Name: | malYp |
+1: | 1700840 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 117 |
Sequence: |
cgtttgtctgtgaaagatatgtcgcttgttaatgtgcaggcactgaaggacaatcgggcaAttggcgtagtacaacttaat -35 -10 +1 |
Evidence: |
[CV(RS-EPT-CBR)] [CV(TIM)] [RE] [RS-EPT-CBR] [TIM] |
Reference(s): |
[7] Li Z., et al., 2019 [8] Salgado H, et al., 2012 |
Reference(s) |
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