RegulonDB RegulonDB 10.6.3: Operon Form
   

malXY operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: malXY
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: malXY
Synonym(s): OP00176
Gene(s): malX, malY   Genome Browser M3D Gene expression COLOMBOS
Note(s): The malY and malX genes are defined as part of the same operon according to their chromosomal positions, their induction pattern, and the polar effect on malY caused by an insertion in malX, but it is not clear whether malY is the last gene in this operon.
In addition, the 5' portion of the malY gene contains stretches of sequences that would allow the formation of two stable stem-and-loop structures. The possible significance of these structures is unknown.
Evidence: [BTEI] Boundaries of transcription experimentally identified
[PM] Polar mutation
Reference(s): [1] Otsuka J., et al., 1996
[2] Reidl J., et al., 1991
Promoter
Name: malXp
+1: 1699313
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 42
Sequence: tcgttgcgtaatgtgatttatgcctcactaaaatttgataaaacgttttatcttctcgcgCaatttactgaatccagattg
                            -35                  -10        +1                   
Evidence: [ICA]
[TIM]
Reference(s): [3] Lloyd GS., et al., 2008
[2] Reidl J., et al., 1991
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote CRP-cAMP1 activator malXp 1699201 1699222 -101.5 tactccctgaTTATGTGACAGATAAAACGTTTtaccttttat nd [AIBSCS], [BPP], [GEA], [SM] [3], [4]
proximal CRP-cAMP2 activator malXp 1699261 1699282 -41.5 tatcgttgcgTAATGTGATTTATGCCTCACTAaaatttgata nd [AIBSCS], [BCE], [BPP], [GEA], [SM] [2], [3], [5], [6]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MalI repressor malXp 1699288 1699305 -16.5 cactaaaattTGATAAAACGTTTTATCTtctcgcgcaa nd [BCE], [GEA], [SM] [2], [5], [6]
Note(s): 1CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008
2CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,20081CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008
2CRP site 2 (-101.5) plays little or no role in CRP-dependent activation of the malX promoter. It might function synergistically with the downstream bound CRP, site 1 (-41.5) Lloyd GS,2008





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