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| Operon |  |
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| Name: | cysDNC |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | cysDNC | |||||||||
| Synonym(s): | cysD, cysNC | |||||||||
| Gene(s): | cysC, cysN, cysD Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | Originally, there were two operons, cysNC and cysD, described. In Leyh TS,1988, it was demonstrated that cysN and cysC were both contained in one operon. The evidence was the strong polarity between cysN and cysC, although no promoter was described. It was not determined whether the upstream gene (cysD) was part of the same operon, but the authors suggested that all the genes could be transcribed because their products are part of the same metabolic pathway. In a more recent paper, Malo MS,1990, a promoter upstream of cysD was described. In a third reference, Leyh TS,1992, it is proposed that the three genes are translationally coupled, confirming that they reside within the same operon. Additionally, a terminator of transcription has also been identified. | |||||||||
| Evidence: | [BTEI] Boundaries of transcription experimentally identified [IEP] Inferred from expression pattern [ITCR] Inferred through co-regulation [PM] Polar mutation |
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| Reference(s): |
[1] Leyh TS., et al., 1988 [2] Leyh TS., et al., 1992 [3] Malo MS., et al., 1990 |
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| Promoter | ||||||||||
| Name: | cysDp | |||||||||
| +1: | 2876368 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 39 | |||||||||
| Sequence: |
aactactcattctaattggtaatttcattcgttctcttacgctccctatagtcgaaacatCtgatggcaagaaaatagcgg -35 -10 +1 |
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| Evidence: |
[HIPP] [ICWHO] [IHBCE] [TIM] |
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| Reference(s): |
[4] Huerta AM., et al., 2003 [3] Malo MS., et al., 1990 |
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| Terminator(s) | ||||||||||
| Type: | rho-independent | |||||||||
| Sequence: | cgcaaataacCAGGAGATAAAACCGACCACGGCACCAGGCAGTGACCATGTGGTTTCTTCAtcctcagtaa | |||||||||
| Reference(s): | [2] Leyh TS., et al., 1992 | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | CysB-O-acetyl-L-serine | activator | cysDp | 2876432 | 2876473 | -85.0 | cggtgccttaAGCACTTTTTGATATTAGCTTTGCCAAATCGTTATTCCGTTAaggaactact | nd | [BCE] | nd |
| Reference(s) |
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|---|---|
[HIPP] Human inference of promoter position