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| Operon |  |
|---|---|
| Name: | nupC |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | nupC | |||||||||
| Synonym(s): | OP00198 | |||||||||
| Gene(s): | nupC Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | The nupC gene is regulated by Nac, CRP, and CytR. Two CRP-binding sites have been identified at -40.5 and -89.5 bp upstream of the transcriptional start site. Since no CytR-binding site has been identifed, it was suggested that the CytR protein could bind to a region between the two sites of CRP, such as in the regulatory regions of the deo and cdd operons Craig JE,1994. | |||||||||
| Reference(s): | [1] Craig JE., et al., 1994 | |||||||||
| Promoter | ||||||||||
| Name: | nupCp | |||||||||
| +1: | 2513009 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 33 | |||||||||
| Sequence: |
acgtcattatagtgtgtgtcagatctcgttttccttaaccatgttacatagaatgtgcacGgaaatttaacctgcctcata -35 -10 +1 |
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| Note(s): | The -10 and -35 regions of the nupCp promoter have been identified with the sequences TAGAAT and TCTCGT, respectively. There is a CRP-binding site overlapping the -35 region Craig JE,1994. | |||||||||
| Evidence: |
[HIPP] [ICWHO] [RS-EPT-CBR] [TIM] |
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| Reference(s): |
[1] Craig JE., et al., 1994 [2] Huerta AM., et al., 2003 [3] Salgado H, et al., 2012 [4] Valentin-Hansen P., et al., 1991 |
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| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | CRP-cyclic-AMP | activator | nupCp | 2512909 | 2512930 | -89.5 | aacatagcagAAATGTATGACAGATCACTATTtttgaagcct | nd | [GEA], [APIORCISFBSCS] | [1], [5] |
| proximal | CRP-cyclic-AMP | activator | nupCp | 2512958 | 2512980 | -40.5 | gacgtcattaTAGTGTGTGTCAGATCTCGTTTTccttaaccat | nd | [GEA], [AIBSCS], [APIORCISFBSCS] | [1], [4], [5], [6] |
| Reference(s) |
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|---|---|
[HIPP] Human inference of promoter position