RegulonDB RegulonDB 11.1: Operon Form
   

uvrYC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: uvrYC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: uvrC
Gene(s): uvrC   Genome Browser M3D Gene expression COLOMBOS
Promoter
Name: uvrCp3
+1: 1994879
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 173
Sequence: gaaaaaacagaaagcccatttgccagtttgtctgaacgtgaattgcagattatgctgatgAtcaccaagggccagaaggtc
                                 -35                    -10 +1                   
Evidence: [COMP-AINF]
[COMP-HINF-POSITIONAL-IDENTIFICATION]
[EXP-IDA-TRANSCRIPTION-INIT-MAPPING]
Reference(s): [1] Huerta AM., et al., 2003
[2] van Sluis CA., et al., 1983
TF binding sites (TFBSs)
[LexA,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd LexA repressor uvrCp3 nd nd nd nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [3]


Transcription unit          
Name: uvrYC
Gene(s): uvrC, uvrY   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [4] Moolenaar GF., et al., 1987
Promoter
Name: uvrYp2
+1: 1995406
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 47
Sequence: aaaatcgaatacccaccatttttaacgtttcaaagttgcaataaaaaccgctaatatacgAatgactaactatcagtagcg
                                  -35                    -10+1                   
Evidence: [COMP-AINF]
[COMP-HINF-POSITIONAL-IDENTIFICATION]
[EXP-IDA-TRANSCRIPTION-INIT-MAPPING]
Reference(s): [1] Huerta AM., et al., 2003
[4] Moolenaar GF., et al., 1987
TF binding sites (TFBSs)
[LexA,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote LexA repressor uvrYp2 1995526 1995545 -129.5 tcgtagggctTACTGTGAAACGATCCGGTAagccgttggt nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS] W [3]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [COMP-HINF-POSITIONAL-IDENTIFICATION] Human inference of promoter position

 [EXP-IDA-TRANSCRIPTION-INIT-MAPPING] Transcription initiation mapping

 [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

 [COMP-AINF-SIMILAR-TO-CONSENSUS] Automated inference based on similarity to consensus sequences


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] van Sluis CA., Moolenaar GF., Backendorf C., 1983, Regulation of the uvrC gene of Escherichia coli K12: localization and characterization of a damage-inducible promoter., EMBO J 2(12):2313-8

 [3] Stark T., Moses RE., 1989, Interaction of the LexA repressor and the uvrC regulatory region., FEBS Lett 258(1):39-41

 [4] Moolenaar GF., van Sluis CA., Backendorf C., van de Putte P., 1987, Regulation of the Escherichia coli excision repair gene uvrC. Overlap between the uvrC structural gene and the region coding for a 24 kD protein., Nucleic Acids Res 15(10):4273-89

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