|Gene(s):||argC, argB, argH Genome Browser M3D Gene expression COLOMBOS|
|Note(s):||argCBH is also controlled by RpoS during the entry into the stationary phase. However, 16504055 could not determined if the rpoS effect was direct or indirect.
argCBH operon expression is downregulated upon L-valine addition (isoleucine starvation) in the cellular growth medium 32211022.
Based on DNA microarray analysis, the mechanism of bacterial inactivation by carvacrol and citral was studied 28644990. Treatment by both compounds caused membrane damage and activated metabolism through the production of nucleotides required for DNA and RNA synthesis and metabolic processes 28644990. A total of 76 and 156 genes demonstrated significant transcriptional differences by carvacrol and citral, respectively. Genes upregulated by carvacrol treatment included the multidrug efflux pump genes acrA and mdtM, genes related to the phage shock response, pspA, pspB, pspC, pspD, pspF, and pspG, and genes whose products are important for biosynthesis of arginine (argC, argG, artJ) and purine nucleotides (purC, purM). Genes upregulated by citral treatment included purH, pyrB, and pyrI. On the other hand, mutations in several differentially expressed genes confirmed the roles of ygaV, yjbO, pspC, sdhA, yejG, and ygaV in mechanisms of inactivation by carvacrol and citral 28644990.
 Natter W., et al., 1977
 Sens D., et al., 1977
|Sigma Factor:||Sigma70 Sigmulon|
|Distance from start of the gene:||116|
-35 -10 +1
 Huerta AM., et al., 2003
 Piette J., et al., 1982
|Type||Transcription factor||Function||Promoter||Binding Sites||Growth Conditions||Evidence (Confirmed, Strong, Weak)||Reference(s)|
|proximal||ArgR-L-arginine||repressor||argCp||4154873||4154890||-3.5||ggtcatgataGTATCAATATTCATGCAGTatttatgaat||nd||[AIBSCS], [BCE], [BPP], [GEA], [SM]|||
|proximal||ArgR-L-arginine||repressor||argCp||4154895||4154912||19.5||atgcagtattTATGAATAAAAATACACTAacgttgagcg||nd||[EME], [AIBSCS], [AIBSPD], [BCE], [BPP], [CEE], [GEA], [SM]||, |
|Transcription factor||Function||Promoter||Binding Sites||Evidence (Confirmed, Strong, Weak)||Reference(s)|
|Gene(s):||argH Genome Browser M3D Gene expression COLOMBOS|
|Evidence:||[NBDA] No biological data available|
 Piette J., Cunin R., Boyen A., Charlier D., Crabeel M., Van Vliet F., Glansdorff N., Squires C., Squires CL., 1982, The regulatory region of the divergent argECBH operon in Escherichia coli K-12., Nucleic Acids Res 10(24):8031-48
 Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86
 Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54