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Name: | hisJQMP |
Gene(s): | hisP, hisM, hisQ, hisJ Genome Browser M3D Gene expression COLOMBOS |
Note(s): | ArgR regulator can control hisJ gene expression through topological changes on the promoter region, inhibiting RNA polymerase binding Caldara M,2007 |
Evidence: | [PAGTSBP] Products of adjacent genes in the same biological process |
Promoter | |
Name: | hisJp |
+1: | 2426837 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 49 |
Sequence: |
atacgtctaacggggcgggatattttgccttgatggtcaattttatggcacgataagtgtAacaaacctgtaaatattccc -35 -10 +1 |
Evidence: |
[CV(RS-EPT-CBR)] [CV(TIM)] [IEP] [RS-EPT-CBR] [TIM] |
Reference(s): |
[1] Caldara M., et al., 2007 [2] Salgado H, et al., 2012 [3] Zaslaver A., et al., 2006 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | ArgR-L-arginine | repressor | hisJp | 2426891 | 2426909 | -62.5 | taagcattttTAATGAAAAATAATACGTCtaacggggcg | nd | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [4], [5] |
proximal | ArgR-L-arginine | repressor | hisJp | 2426912 | 2426930 | -83.5 | tggtgcattgAAATGCATACTTAAGCATTtttaatgaaa | nd | [BPP], [CV(SM)], [GEA], [SM] | [1] |
Name: | argT-hisJQMP |
Gene(s): | hisP, hisM, hisQ, hisJ, argT Genome Browser M3D Gene expression COLOMBOS |
Evidence: | [PAGTSBP] Products of adjacent genes in the same biological process |
Reference(s): | [7] Zimmer DP., et al., 2000 |
Promoter | |
Name: | argTp |
+1: | 2427849 |
Sigma Factor: | Sigma54 Sigmulon |
Distance from start of the gene: | 58 |
Sequence: |
tatttaacgttgaatgttactgttgtcgtcaagatggcataagacctgcatgaaagagccTgcaaacacacaacacaatac -24 -12 +1 |
Note(s): | We assigned a putative transcription start site to this promoter based on the observation that the majority of the σ54-dependent promoters, whose transcription start sites were determined experimentally, present a distance of 11 nucleotides between the transcription start site and the -12 box Barrios H,1999. |
Evidence: | [AIPP] |
Reference(s): |
[8] Barrios H., et al., 1999 [9] Reitzer L., et al., 2001 [10] Schmitz G., et al., 1987 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | NtrC-Pasp | activator | argTp | 2427924 | 2427940 | -83.0 | tatcttcaacTTCAGGACAATAATGCAacgtcttatt | nd | [AIBSCS], [CV(GEA)], [GEA] | [7] |
remote | NtrC-Pasp | activator | argTp | 2428031 | 2428047 | -190.0 | actccgctgtTGCCCTGTTTCAGGGCAattttgcaac | nd | [AIBSCS], [CV(GEA)], [GEA] | [7] |
Allosteric regulation of RNA-polymerase |
Regulator | Function | Promoter target of RNApol | Growth Conditions | Note | Evidence | Reference | |
---|---|---|---|---|---|---|---|
ppGpp | inhibition | argTp |
The argT promoter is negatively affected by ppGpp in vivo Rowley KB,1993and in vitro during the stringent response Toulokhonov II,2001. Based on results of nuclease protection and primer extension assays, leuV, argT, metT, and leuX were determined to be involved in the stringent response induced by serine hydroxamate Rowley KB,1993. |
[GEA] [IEP] |
[11] [12] |
Evidence: |
[GEA] Gene expression analysis [IEP] Inferred from expression pattern |
Reference(s): |
[11] Rowley KB., et al., 1993 [12] Toulokhonov II., et al., 2001 |
Regulation by sRNA | ![]() |
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Small RNA name (Regulator) | Regulation type | Mechanism | Function | Binding Sites | Evidence | Reference | |||
---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Sequence (RNA-strand) | |||||||
gcvB | antisense | translational regulation | repressor | 2427824 | 2427849 | TGCAAACACACAACACAATACACAA |
Notes: "The provided sequence is that of the RNA strand,i.e. 'U's are showed instead the 'T'" |
Reference(s) |
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