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| Operon |  |
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| Name: | csrB |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | csrB | |||||||||
| Gene(s): | csrB Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | Based on gene expression analysis, Jonas K,2006determined that the csrB and csrC genes are under positive control of YhdA. However, they did not show direct evidence for YhdA binding to the crsBp and csrCp promoters. Although there are two potential binding sites for CRP, CRP1 (ttgTGAGAgatctcTTACAgac) and CRP2 (ctcGGTGTgtaatcTCTCCggt), on the regulatory regions of the csrB gene, it was found that CRP binds nonspecifically on these sites, negatively affecting csrB transcription in an indirect way Pannuri A,2016 Based on microarray and RT-qPCR analyses, it was determined that the csrB gene is downregulated upon exposure to glutathione (GSH) Goswami M,2018 The csrB gene is upregulated by long-term (8 to 12 h) exposure of E. coli to some biocides Merchel Piovesan Pereira B, Wang X, Tagkopoulos I,2020. |
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| Evidence: | [BTEI] Boundaries of transcription experimentally identified [LTED] Length of transcript experimentally determined |
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| Reference(s): | [1] Liu MY., et al., 1997 | |||||||||
| Promoter | ||||||||||
| Name: | csrBp | |||||||||
| +1: | 2924524 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 0 | |||||||||
| Sequence: |
ccttaaggcattgtctgtaagcgccttgtaagacttcgcgaaaaagacgattctatcttcGtcgacagggagtcagacaac -35 -10 +1 |
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| Evidence: |
[HTTIM]   [ICWHO] [RS-EPT-CBR] [TIM] |
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| Reference(s): |
[2] Gudapaty S., et al., 2001 [3] Huerta AM., et al., 2003 [4] Mendoza-Vargas A., et al., 2009 [5] Salgado H, et al., 2012 |
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| Terminator(s) | ||||||||||
| Type: | rho-independent | |||||||||
| Sequence: | aataaaaaaaGGGAGCACTGTATTCACAGCGCTCCCggttcgtttc | |||||||||
| Reference(s): | [1] Liu MY., et al., 1997 | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| remote | UvrY-phosphorylated | activator | csrBp | 2924698 | 2924716 | -183.0 | ccccatctggTTGTGAGAGATCTCTTACAgactctgtag | nd | [GEA], [BPP] | [6], [7] |
| Reference(s) |
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[HTTIM] High-throughput transcription initiation mapping