RegulonDB RegulonDB 10.6.3: Operon Form
   

uxuR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: uxuR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: uxuR
Gene(s): uxuR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [IEP] Inferred from expression pattern
[IMP] Inferred from mutant phenotype
Reference(s): [1] Ritzenthaler P., et al., 1981
Promoter
Name: uxuRp
+1: 4554458
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 118
Sequence: actgatatttggttgaccagttttcgtttttttgcccacctgtacgtgccaacttccagtGctaatggtatagtttgagat
                           -35                    -10       +1                   
Evidence: [AIPP]
Reference(s): [2] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd CRP-cAMP activator uxuRp nd nd nd nd nd [GEA], [HIBSCS] [5], [6]
[ExuR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal ExuR repressor uxuRp 4554403 4554420 -46.5 atcaaactgaTATTTGGTTGACCAGTTTtcgttttttt nd [AIBSCS], [GEA] [3], [4], [5]
[UxuR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal UxuR repressor uxuRp 4554383 4554400 -66.5 ccctacagacTTACTGGTCAATCAAACTgatatttggt nd [AIBSCS] [3]
proximal UxuR repressor uxuRp 4554403 4554420 -46.5 atcaaactgaTATTTGGTTGACCAGTTTtcgttttttt nd [AIBSCS], [GEA] [3], [4], [5]
remote UxuR repressor uxuRp 4554542 4554559 93.5 atccggcaaaAATTTGATTAACCGCACCtaacggacac nd [AIBSCS], [GEA] [3]


Evidence    

 [AIPP] Automated inference of promoter position

 [GEA] Gene expression analysis

 [HIBSCS] Human inference based on similarity to consensus sequences

 [AIBSCS] Automated inference based on similarity to consensus sequences


Reference(s)    

 [1] Ritzenthaler P., Mata-Gilsinger M., Stoeber F., 1981, Molecular cloning of Escherichia coli K-12 hexuronate system genes: exu region., J Bacteriol 145(1):181-90

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Ritzenthaler P., Mata-Gilsinger M., 1983, Multiple regulation involved in the expression of the uxuR regulatory gene in Escherichia coli K-12., Mol Gen Genet 189(2):351-4

 [4] Ritzenthaler P., Blanco C., Mata-Gilsinger M., 1985, Genetic analysis of uxuR and exuR genes: evidence for ExuR and UxuR monomer repressors interactions., Mol Gen Genet 199(3):507-11

 [5] Rodionov DA., Mironov AA., Rakhmaninova AB., Gelfand MS., 2000, Transcriptional regulation of transport and utilization systems for hexuronides, hexuronates and hexonates in gamma purple bacteria., Mol Microbiol 38(4):673-83

 [6] Ritzenthaler P., Mata-Gilsinger M., 1982, Use of in vitro gene fusions to study the uxuR regulatory gene in Escherichia coli K-12: direction of transcription and regulation of its expression., J Bacteriol 150(3):1040-7

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