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Name: | hycABCDEFGHI |
Synonym(s): | OP00208 |
Gene(s): | hycI, hycH, hycG, hycF, hycE, hycD, hycC, hycB, hycA Genome Browser M3D Gene expression COLOMBOS |
Note(s): | Regulation of the hyc operon by ZraR (HydG) was suggested. However, this protein is not a physiological regulator of the operon Leonhartsberger S,2001 |
Evidence: | [BTEI] Boundaries of transcription experimentally identified |
Reference(s): |
[1] Bohm R., et al., 1990 [2] Hopper S., et al., 1994 [3] Rossmann R., et al., 1995 |
Promoter | |
Name: | hycAp |
+1: | 2850461 |
Sigma Factor: | Sigma54 Sigmulon |
Distance from start of the gene: | 26 |
Sequence: |
ttaaaaatctctttaataacaataaattaaaagttggcacaaaaaatgcttaaagctggcAtctctgttaaacgggtaacc -24 -12 +1 |
Evidence: |
[CV(RS-EPT-CBR/TA)] [CV(TA/TIM)] [RS-EPT-CBR] [TIM] |
Reference(s): |
[4] Lutz S., et al., 1990 [5] Salgado H, et al., 2012 |
Terminator(s) | |
Type: | rho-independent |
Sequence: | aaccatgaagGCCCGATAAGCGCAGCGCATCGGGCaatttagcat |
Reference(s): | [3] Rossmann R., et al., 1995 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | FhlA-formate | activator | hycAp | 2850539 | 2850552 | -84.5 | cgaaatgacaCGTCGACACGGCGAcgaaattcat | nd | [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] | [2], [7], [8] |
remote | FhlA-formate | activator | hycAp | 2850553 | 2850566 | -98.0 | aatgtcgatgATGTCGAAATGACAcgtcgacacg | nd | [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] | [2], [7], [8], [9] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | IHF | activator | hycAp | 2850493 | 2850505 | -38.5 | atctctttaaTAACAATAAATTAaaagttggca | nd | [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] | [2] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | ModE-MoO42-1 | activator | hycAp | 2850641 | 2850664 | -192.0 | cccgttggcaGAGGGTTATTTCGTGCATATCGCCtcccattaac | nd | [BPP], [GEA] | [6] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | NsrR | repressor | hycAp | 2850526 | 2850537 | -70.0 | acacggcgacGAAATTCATCTTtagcttaaaa | nd | [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] | [10] |
Note(s): |
1A model has been proposed in which ModE-molybdate serves as a secondary transcriptional activator of both the hyc and narXL operons, which are activated primarily by the transcriptional activators FhlA and NarL, respectively. Both ModE and MoeA are needed for maximal expression of the hyc operon. MoeA does not bind DNA 9851041 and it was suggested that it activates molybdenum by sulfurylation 95159151A model has been proposed in which ModE-molybdate serves as a secondary transcriptional activator of both the hyc and narXL operons, which are activated primarily by the transcriptional activators FhlA and NarL, respectively. Both ModE and MoeA are needed for maximal expression of the hyc operon. MoeA does not bind DNA 9851041 and it was suggested that it activates molybdenum by sulfurylation 9515915 |
RNA cis-regulatory element | ![]() |
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Regulation, transcriptional elongation | |
Attenuator type: | Transcriptional |
Strand: | reverse |
Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
---|---|---|---|---|---|
terminator | -16.6 | 2849883 | 2849923 | gggatgggcgTGTCGATGAGTGTCGAAAATGACATTTCATCGGCATGTTTtcgtcaaaaa | |
anti-terminator | -14.8 | 2849911 | 2849953 | tgcccgttttGCAGGCGTTACGCCTGTTTGGGGATGGGCGTGTCGATGAGTGtcgaaaatga | |
anti-anti-terminator | -14.8 | 2849932 | 2849961 | tgaggctttgCCCGTTTTGCAGGCGTTACGCCTGTTTGGggatgggcgt |
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
Reference(s) |
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